Protein Information

Name basic fibroblast growth factor
Synonyms BFGF; BHBGF 2; BHBGF2; Basic fibroblast growth factor; FGF; FGF2; FGFB; Fibroblast growth factor 2…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
19957847 Yan L, Cai H, Chen Y, Tan W: [Effect of hepatocyte-like cells induced by CD34+ cells in vitro on the repair of injured hepatic tissues of mice in vivo]. Cell Tissue Res. 2007 Mar;327(3):463-70. Epub 2006 Nov 9.

The cells were (1 x 10 (5) cells/mL) cultured in serum-free medium containing stem cell factor (SCF), hepatocyte growth factor (HGF), EGF, oncostatin M (OSM), bFGF (the concentration were 50, 20, 20, 10, 10 ng/mL respectively) in vitro for 10 days.
Forty-eight 6-week-old female ICR mice were chosen to prepare liver injury model by injecting carbon tetrachloride and 2-acetylamionoflu-orene.
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19056764 Kamada Y, Yoshida Y, Saji Y, Fukushima J, Tamura S, Kiso S, Hayashi N: Transplantation of basic fibroblast growth factor-pretreated adipose tissue-derived stromal cells enhances regression of liver fibrosis in mice. Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G157-67. Epub 2008 Dec 4.

In the in vivo study, ADSC isolated from green fluorescent protein-transgenic mice were transplanted into carbon tetrachloride-injured C57BL6/J mice liver. bFGF-treated ADSC expressed several liver-specific marker genes and demonstrated liver-related functions such as albumin secretion, glycogen synthesis, urea production, and low-density lipoprotein uptake.
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17093919 Ishikawa T, Terai S, Urata Y, Marumoto Y, Aoyama K, Murata T, Mizunaga Y, Yamamoto N, Nishina H, Shinoda K, Sakaida I: Administration of fibroblast growth factor 2 in combination with bone marrow transplantation synergistically improves carbon-tetrachloride-induced liver fibrosis in mice. 222.
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16116963 Peng X, Wang B, Wang T, Zhao Q: Expression of basic fibroblast growth factor in rat liver fibrosis and hepatic stellate cells. J Huazhong Univ Sci Technolog Med Sci. 2005;25(2):166-9

Liver fibrosis was induced by subcutaneous injection of carbon tetrachloride.
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16228231 Ishikawa T, Terai S, Urata Y, Marumoto Y, Aoyama K, Sakaida I, Murata T, Nishina H, Shinoda K, Uchimura S, Hamamoto Y, Okita K: Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes. Cell Tissue Res. 2006 Feb;323(2):221-31. Epub 2005 Oct 14.

We have developed an in vivo mouse model, the green fluorescent protein (GFP)/carbon tetrachloride (CCl (4)) model, and have previously reported that transplanted GFP-positive bone marrow cells (BMCs) differentiate into hepatocytes via hepatoblast intermediates.
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19513901 Zhao Q, Ren H, Li X, Chen Z, Zhang X, Gong W, Liu Y, Pang T, Han ZC: Differentiation of human umbilical cord mesenchymal stromal cells into low immunogenic hepatocyte-like cells. Cytotherapy. 2009;11(4):414-26.


RESULTS: After incubation with specific growth factors, including hepatocyte growth factor (HGF) and basic fibroblast growth factor (bFGF), UC MSC exhibited a high hepatic differentiation ability in an adherent culture condition.
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