| Name | interleukin 1beta |
|---|---|
| Synonyms | Catabolin; IL 1; IL 1 beta; IL 1B; IL1 beta; IL1B; IL1F2; Interleukin 1… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17383825 | Reyes-Gordillo K, Segovia J, Shibayama M, Vergara P, Moreno MG, Muriel P: protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. Hepatology. 2009 Aug;50(2):601-11. an anti-inflammatory and antioxidant compound, was evaluated for its ability to suppress acute carbon tetrachloride-induced liver damage. Therefore, in this study we determined the concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) mRNA, and NF-kappaB activation. |
3(0,0,0,3) | Details |
| 16762003 | Roderfeld M, Geier A, Dietrich CG, Siewert E, Jansen B, Gartung C, Roeb E: Cytokine blockade inhibits hepatic tissue inhibitor of metalloproteinase-1 expression and up-regulates matrix metalloproteinase-9 in toxic liver injury. Toxicol Sci. 2008 Oct;105(2):418-28. Epub 2008 Jul 12. Male Sprague-Dawley rats were treated with carbon tetrachloride (CCl4) in the presence and absence of specific TNF-alpha and IL-1beta inhibitors. |
35(0,1,1,5) | Details |
| 17157831 | Wills PJ, Asha VV: Protective mechanism of Lygodium flexuosum extract in treating and preventing carbon tetrachloride induced hepatic fibrosis in rats. Chem Biol Interact. 2007 Jan 5;165(1):76-85. Epub 2006 Nov 2. The expression levels of tumor necrosis factor-alpha, interleukin-1beta, transforming growth factor-beta1, procollagen-I, procollagen-III and tissue inhibitor of metalloproteinase-1 were elevated during carbon tetrachloride administration and reduced the levels to normal by the treatment with the extract treatment. |
31(0,1,1,1) | Details |
| 18507761 | Yan C, Zhou L, Han YP: Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure. Liver Int. 2008 Aug;28(7):959-71. Epub 2008 May 27. METHODS: Mice were given lipopolysaccharide (LPS) and beta-galactosamine (GA) or carbon tetrachloride to create ALF and establish the association of IL-1, MMP-9, and caspase-3 in acute liver failure. |
10(0,0,1,5) | Details |
| 18806959 | Lee HS, Jung KH, Hong SW, Park IS, Lee C, Han HK, Lee DH, Hong SS: Morin protects acute liver damage by carbon tetrachloride (CCl (4)) in rat. Toxicol Appl Pharmacol. 2008 Jan 1;226(1):38-45. Epub 2007 Aug 24. To identify the mechanism of protective activity of morin in CCl (4)-induced hepatotoxicity in rats, we investigated expressions of tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and inducible (iNOS). |
3(0,0,0,3) | Details |
| 15586409 | Yao HW, Li J, Chen JQ, Xu SY: [The active metabolite of leflunomide A771726 inhibits proliferation and collagen synthesis of hepatic stellate cell]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2004 Nov;33(6):515-8 The TGF-beta, TNF-alpha and IL-1 levels in Kupffer cell conditioned medium (KCCM) were determined by enzyme-linked immunosorbent assay (ELISA). |
3(0,0,0,3) | Details |
| 17904177 | Yamaji K, Ohnishi K, Zuinen R, Ochiai Y, Chikuma T, Hojo H: Interleukin-6 production by peritoneal mesothelial cells and its regulation by inflammatory factors in rats administered carbon tetrachloride intraperitoneally. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):318-25. Epub 2009 Nov 11. Analyses of PEF revealed that the levels of (2) (PGE (2)), IL-1alpha, IL-1beta and tumor necrosis factor-alpha (TNF-alpha) increased immediately after ip CCl (4) administration. |
3(0,0,0,3) | Details |
| 15902742 | Gui SY, Wei W, Wang H, Wu L, Sun WY, Wu CY: Protective effect of fufanghuangqiduogan against acute liver injury in mice. World J Gastroenterol. 2005 May 21;11(19):2984-9. METHODS: ALI was successfully induced by injecting carbon tetrachloride (CCl4) intraperitoneally and by tail vein injection of Bacillus Calmette Guerin (BCG) and lipopolysaccharide (LPS) in mice, respectively. The activities of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) were determined by radio-immunoassay. |
2(0,0,0,2) | Details |
| 15925388 | Wang H, Wei W, Wang NP, Gui SY, Wu L, Sun WY, Xu SY: ameliorates carbon tetrachloride-induced hepatic fibrogenesis in rats via inhibition of oxidative stress. 528. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) concentrations in Kupffer cells (KCs) culture supernatants were measured with ELISA. |
2(0,0,0,2) | Details |
| 20004152 | D'Argenio G, Amoruso DC, Mazzone G, Vitaglione P, Romano A, Ribecco MT, D'Armiento MR, Mezza E, Morisco F, Fogliano V, Caporaso N: Garlic extract prevents CCl (4)-induced liver fibrosis in rats: The role of tissue transglutaminase. Biochim Biophys Acta. 2007 Jun;1770(6):989-96. Epub 2007 Feb 22. METHODS: Rat liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride (CCl (4)) for 7 weeks. Reverse transcription-polymerase chain reaction to detect alpha-SMA, IL-1beta and tissue transglutaminase expression and Western blot for tissue transglutaminase protein amount were performed. |
2(0,0,0,2) | Details |
| 19913046 | Shim JY, Kim MH, Kim HD, Ahn JY, Yun YS, Song JY: Protective action of the immunomodulator ginsan against carbon tetrachloride-induced liver injury via control of oxidative stress and the inflammatory response. Dig Liver Dis. 2009 Dec 7. The marked increase of proinflammatory cytokines (IL-1beta, IFN-gamma) and chemokines (MCP-1, MIP-2beta, KC) in CCl (4) treated mice was additionally attenuated by ginsan, thereby preventing leukocyte infiltration and local inflammation. |
1(0,0,0,1) | Details |
| 15685554 | Fischer R, Reinehr R, Lu TP, Schonicke A, Warskulat U, Dienes HP, Haussinger D: Intercellular communication via gap junctions in activated rat hepatic stellate cells. Am J Chin Med. 2010;38(1):99-111. At the long-term level, (3) , lipopolysaccharide, thyroid hormone T (3), dexamethasone, platelet-derived growth factor, endothelin 1, and interleukin 1beta up-regulate connexin 43 protein and messenger RNA expression and enhance intercellular communication. |
1(0,0,0,1) | Details |
| 15830285 | Mikami K, Goto T, Miura K, Ohshima S, Yoneyama K, Lin JG, Watanabe D, Segawa D, Kataoka E, Shibuya T, Watanabe S: Gabexate mesilate, a synthetic protease inhibitor, attenuates carbon tetrachloride-induced liver injury in rats. J Gastroenterol. 2005 Mar;40(3):260-5. Plasma tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) decreased significantly in the gabexate mesilate-treated rats compared with saline-treated rats. |
1(0,0,0,1) | Details |
| 15337842 | Askari FK, Dick R, Mao M, Brewer GJ: Tetrathiomolybdate therapy protects against concanavalin a and carbon tetrachloride hepatic damage in mice. Gastroenterology. 2005 Feb;128(2):433-48. In additional experiments, tetrathiomolybdate therapy reversed the elevated serum transaminase levels despite continued concanavalin A injections, with nearly significant serum interleukin-1beta inhibition. |
1(0,0,0,1) | Details |
| 17374462 | Zuinen R, Yamaji K, Aoki M, Chikuma T, Hojo H: Early induced, high-level interleukin-6 expression in the rat peritoneal cavity into which a hepatotoxicant carbon tetrachloride was administered. Toxicol Lett. 2007 Apr 5;170(1):42-8. Epub 2007 Feb 20. TNF-alpha and IL-1beta levels gradually increased, reaching the maximum at 24h. |
1(0,0,0,1) | Details |
| 20128048 | Wu SJ, Tam KW, Tsai YH, Chang CC, Chao JC: and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats. Liver Int. 2006 Jun;26(5):579-86. Carbon tetrachloride (40% in olive oil) at a dose of 0.75 ml/kg was injected intraperitoneally once a week. Hepatic proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 were significantly inhibited, and anti-inflammatory cytokine interleukin-10 was significantly increased by supplementation with and/or saikosaponin A. |
1(0,0,0,1) | Details |
| 16510928 | Topuria D, Kakabadze Z, Lobdjanidze N, Chavchanidze N: Anti-hepato-cytotoxic serum treatment results in acute liver failure. . Georgian Med News. 2006 Jan;(130):111-5. Elevated serum concentrations of bacterial endotoxin, tumor necrosis factor-a, and interleukin-1 and interleukin-6 have been found in FHF, but the specific roles of these inflammatory factors are unclear. |
1(0,0,0,1) | Details |
| 14758566 | Otte C, Otte JM, Strodthoff D, Bornstein SR, Folsch UR, Monig H, Kloehn S: Expression of leptin and leptin receptor during the development of liver fibrosis and cirrhosis. Exp Biol Med. 2004 Sep;229(8):857-63. Major secretagogues are cytokines such as TNF-alpha or IL-1. |
1(0,0,0,1) | Details |
| 17412915 | Amatucci A, Novobrantseva T, Gilbride K, Brickelmaier M, Hochman P, Ibraghimov A: Recombinant ST2 boosts hepatic Th2 response in vivo. J Leukoc Biol. 2007 Jul;82(1):124-32. Epub 2007 Apr 5. The TLR/IL-1 receptor (IL-1R)-related protein ST2 is expressed in a membrane-bound form selectively by Th2 cells and was shown to be indispensable for some in vivo Th2 responses. We addressed the impact of the ST2 pathway on fibrogenesis using a mouse model of hepatic injury and fibrosis induced by carbon tetrachloride (CCl (4)). |
1(0,0,0,1) | Details |
| 18622026 | Shan W, Palkar PS, Murray IA, McDevitt EI, Kennett MJ, Kang BH, Isom HC, Perdew GH, Gonzalez FJ, Peters JM: Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression. Arch Pharm Res. 2008 Sep;31(9):1160-5. Epub 2008 Sep 20. |
0(0,0,0,0) | Details |
| 19575449 | Yovchev MI, Zhang J, Neufeld DS, Grozdanov PN, Dabeva MD: Thymus cell antigen-1-expressing cells in the oval cell compartment. Life Sci. 2005 Aug 26;77(15):1902-15. We characterized these cells in normal liver, in carbon tetrachloride-injured liver, and in several models of OC activation. |
0(0,0,0,0) | Details |