| PubMed |
Abstract |
RScore(About this table) |
| 6750385 |
Brimer PA, Tan EL, Hsie AW: Effect of metabolic activation on the cytotoxicity and mutagenicity of 1,2-dibromoethane in the CHO/HGPRT system. Mutat Res. 1982 Aug;95(2-3):377-88.
When ethylene dibromide (EtBr2) was assayed with the Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase (CHO/HGPRT) system coupled with a rat liver metabolic activation system (S9), which contains Ca2+ (Ca, Mg-S9), the cytotoxicity of EtBr2 was greatly increased over that obtained when NADP was omitted from the Ca, Mg-S9 or when EtBr2 was assayed as a direct-acting agent. |
32(0,1,1,2) |
Details |
| 7035935 |
Tan EL, Hsie AW: Mutagenicity and cytotoxicity of haloethanes as studied in the CHO/HGPRT system. Mutat Res. 1981 Oct;90(2):183-91.
When haloethanes were being tested as direct-acting agents in the Chinese hamster ovary cell/hypoxanthine-guanine phosphoribosyl transferase (CHO/HGPRT) system, ethylene dibromide (EtBr2) exhibited more cytotoxic and mutagenic activity than ethylene dichloride (EtCl2), and the mixed halogenated congener ethylene bromochloride (EtBrCl) had an intermediate effect. |
7(0,0,1,2) |
Details |
| 8600370 |
Graves RJ, Green T: Mouse liver glutathione S-transferase mediated metabolism of methylene chloride to a mutagen in the CHO/HPRT assay. Mutat Res. 1996 Mar 1;367(3):143-50.
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3(0,0,0,3) |
Details |
| 8671744 |
Graves RJ, Trueman P, Jones S, Green T: DNA sequence analysis of methylene chloride-induced HPRT mutations in Chinese hamster ovary cells: comparison with the mutation spectrum obtained for 1,2-dibromoethane and formaldehyde. Mutagenesis. 1996 May;11(3):229-33.
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2(0,0,0,2) |
Details |