Protein Information

Name HEMA
Synonyms AHF; Antihemophilic factor; Coagulation factor VIII; Coagulation factor VIII precursor; DXS1253E; F8; F8 protein; F8B…

Compound Information

Name ethylene dibromide
CAS 1,2-dibromoethane

Reference List

PubMed Abstract RScore(About this table)
9547405 Barr DB, Ashley DL: A rapid, sensitive method for the quantitation of N-acetyl-S-(2-hydroxyethyl)-L-cysteine in human urine using isotope-dilution HPLC-MS-MS. J Anal Toxicol. 1998 Mar-Apr;22(2):96-104.

We have developed a sensitive and selective method for the analysis of N-acetyl-S-(2-hydroxyethyl)-L-cysteine (HEMA), urinary metabolite of at least three different known human carcinogens (vinyl chloride, ethylene oxide, and ethylene dibromide).
32(0,1,1,2) Details
10489158 Calafat AM, Barr DB, Pirkle JL, Ashley DL: Reference range concentrations of N-acetyl-S-(2-hydroxyethyl)-L-cysteine, a common metabolite of several volatile organic compounds, in the urine of adults in the United States. J Expo Anal Environ Epidemiol. 1999 Jul-Aug;9(4):336-42.


N-acetyl-S-(2-hydroxyethyl)-L-cysteine (2-hydroxyethyl mercapturic acid, HEMA) is a urinary metabolite of several hazardous chemicals, including vinyl chloride (VC), ethylene oxide (EO), and ethylene dibromide (EDB).
6(0,0,0,6) Details
9107551 Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP: Urinary thiodiacetic acid. Drug Metab Dispos. 1997 Apr;25(4):508-15.


In this study, the excretion of thiodiacetic acid (TDA) and S-(2-hydroxyethyl)-N-acetyl-l-cysteine (2-HEMA) were measured in the urine of rats dosed with 1,2-DBE, and experiments were performed to investigate to what extent P450 and GST enzymes contribute to the formation of TDA.
2(0,0,0,2) Details