Protein Information

Name thrombin
Synonyms Coagulation factor II; Coagulation factor II variant; F2; F2 protein; F2 protein precursor; Factor II; PT; Prothrombin…

Compound Information

Name ethylene oxide
CAS oxirane

Reference List

PubMed Abstract RScore(About this table)
12857094 Pompe T, Zschoche S, Herold N, Salchert K, Gouzy MF, Sperling C, Werner C: Maleic anhydride copolymers--a versatile platform for molecular biosurface engineering. Biomacromolecules. 2003 Jul-Aug;4(4):1072-9.

Examples concern the impact of the substrate-anchorage of fibronectin on the formation of cell-matrix adhesions, the orientation of endothelial cells according to lateral anti-adhesive micropatterns using grafted poly (ethylene oxide), and the spacer-dependent activity of immobilized synthetic thrombin inhibitors.
31(0,1,1,1) Details
15143535 Yu G, Ji J, Wang D, Feng L, Shen J: [Blood compatibility of two novel polyurethane coating materials] . Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2004 Apr;21(2):184-7.

Amphiphilic coupling-polymer of stearyl poly (ethylene oxide)-co-4, 4'-methylendiphenyl diisocyanate-co-stearyl poly (ethylene oxide), MSPEO, was specially designed as surface-modifying additives.
Two kinds of static clotting time tests, plasma recalcification time (PRT) and prothrombin time (PT), as well as the static platelet adhesion experiment were carried out.
1(0,0,0,1) Details
19449820 Jung H, Kim JY, Kim Y, Tae G, Kim YH, Johannsmann D: QCM and AFM analysis of anticoagulant activities of sulfonated polymers against fibrin formation. Langmuir. 2009 Jun 16;25(12):7032-41.

Four types of sulfonated polymers including sulfonated chitosan (S-chitosan), monosulfonated poly (ethylene oxide) (PEO-SO (3)), disulfonated PEO (PEO-2SO (3)), and 4-arm sulfonated PEO (PEO-4SO (3)) were studied to compare with heparin in the presence or in the absence of antithrombin III (AT).
All the sulfonated polymers showed the heparin-like activities to inhibit the function of thrombin for fibrin formation in the more or less extent while chitosan and PEO did not.
1(0,0,0,1) Details