Protein Information

Name transferrin
Synonyms Beta 1 metal binding globulin; PRO1400; PRO1557; PRO2086; Serotransferrin; Serotransferrin precursor; Siderophilin; TF…

Compound Information

Name ethylene oxide
CAS oxirane

Reference List

PubMed Abstract RScore(About this table)
18729494 Sahay G, Batrakova EV, Kabanov AV: Different internalization pathways of polymeric micelles and unimers and their effects on vesicular transport. Bioconjug Chem. 2008 Oct;19(10):2023-9. Epub 2008 Aug 27.

A block copolymer of poly (ethylene oxide) (PEO) and poly (propylene oxide) (PPO), Pluronic P85 (P85), below critical micelle concentration (CMC) exists as single molecule coils (unimers) and above CMC forms 14.6 nm aggregated micelles with a hydrophobic PPO core and hydrophilic PEO shell.
The internalization pathways of P85 in mammalian cells were elucidated using endocytosis inhibitors and colocalization with endocytosis markers (clathrin-specific antibodies and transferrin for clathrin and caveolin-1-specific antibodies and cholera toxin B for caveolae).
1(0,0,0,1) Details
16287257 Sen Gupta S, Kuzelka J, Singh P, Lewis WG, Manchester M, Finn MG: Accelerated bioorthogonal conjugation: a practical method for the ligation of diverse functional molecules to a polyvalent virus scaffold. Bioconjug Chem. 2005 Nov-Dec;16(6):1572-9.

The ligated substrates included complex sugars, peptides, poly (ethylene oxide) polymers, and the iron carrier protein transferrin, with routine success even for cases that were previously resistant to azide-alkyne coupling using the conventional ligand tris (triazolyl) amine (1).
31(0,1,1,1) Details