| Name | heme oxygenase 1 |
|---|---|
| Synonyms | HMOX 1; HMOX1; HMOX1 protein; HO; HO 1; HO1; Heme oxygenase (Decycling) 1; Heme oxygenase (Decyclizing) 1… |
| Name | methylene chloride |
|---|---|
| CAS | dichloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14512878 | Sass G, Soares MC, Yamashita K, Seyfried S, Zimmermann WH, Eschenhagen T, Kaczmarek E, Ritter T, Volk HD, Tiegs G: Heme oxygenase-1 and its reaction product, prevent inflammation-related apoptotic liver damage in mice. Hepatology. 2003 Oct;38(4):909-18. Exogenous CO administration or treatment with the CO-releasing agent methylene chloride mimicked the protective effect of HO-1, whereas treatment with exogenous or overexpression of ferritin by recombinant adenoviral gene transfer did not. |
39(0,1,1,9) | Details |
| 12133272 | Ke B, Buelow R, Shen XD, Melinek J, Amersi F, Gao F, Ritter T, Volk HD, Busuttil RW, Kupiec-Weglinski JW: Heme oxygenase 1 gene transfer prevents CD95/Fas ligand-mediated apoptosis and improves liver allograft survival via signaling pathway. Hum Gene Ther. 2002 Jul 1;13(10):1189-99. To deliver CO, one of the downstream HO-1 mediators, allogeneic OLT recipients were exposed to methylene chloride. |
14(0,0,1,9) | Details |
| 20303947 | Lakkisto P, Kyto V, Forsten H, Siren JM, Segersvard H, Voipio-Pulkki LM, Laine M, Pulkki K, Tikkanen I: Heme oxygenase-1 and promote neovascularization after myocardial infarction by modulating the expression of HIF-1alpha, SDF-1alpha and VEGF-B. Eur J Pharmacol. 2010 Mar 19. Prior to coronary artery ligation, male Wistar rats were given either cobolt to induce HO-1 or CO-donor methylene chloride. |
12(0,0,1,7) | Details |
| 12201358 | Chauveau C, Bouchet D, Roussel JC, Mathieu P, Braudeau C, Renaudin K, Tesson L, Soulillou JP, Iyer S, Buelow R, Anegon I: Gene transfer of heme oxygenase-1 and delivery inhibit chronic rejection. Am J Transplant. 2002 Aug;2(7):581-92. treatment was achieved by a new pharmacological approach in transplantation using methylene chloride (MC), which releases CO after degradation. |
4(0,0,0,4) | Details |
| 20044809 | Lehmann E, El-Tantawy WH, Ocker M, Bartenschlager R, Lohmann V, Hashemolhosseini S, Tiegs G, Sass G: The heme oxygenase 1 product interferes with hepatitis C virus replication by increasing antiviral interferon response. Hepatology. 2010 Feb;51(2):398-404. Incubation of these cell lines in the presence of the CO donor methylene chloride transiently reduced HCV replication, whereas an increase of iron in cell culture by administration of FeCl (3) or iron-saturated lactoferrin did not interfere with HCV replication. |
3(0,0,0,3) | Details |
| 20193372 | Yang DH, Zhang H, Huang Y, Zhou J: [Effect of methylene chloride upon hepatic ischemic reperfusion injury] . Zhonghua Yi Xue Za Zhi. 2009 Dec 15;89(46):3299-303. The tests were determined as following: the level of serum ALT, AST in recipients; heme oxygenase-1 (HO-1) expression of graft was tested by immunohistochemistry and Western blot; the index of graft apoptosis examined by TUNEL method; the pathology of graft assessed by Suzuki's criteria. |
3(0,0,0,3) | Details |
| 15486963 | Sass G, Seyfried S, Parreira Soares M, Yamashita K, Kaczmarek E, Neuhuber WL, Tiegs G: Cooperative effect of and on survival of mice in immune-mediated liver injury. Hepatology. 2004 Nov;40(5):1128-35. Induction of the heme-degrading enzyme heme oxygenase-1 (HO-1) has been shown to be beneficial in terms of improvement of liver allograft survival and prevention of CD95-mediated apoptosis in the liver. While in contrast to ferritin overexpression, single administration of the CO donor methylene chloride (MC) or of BV also protected mice from liver damage, only coadministration of both HO products prolonged survival and reduced the expression of cytokines, e.g., tumor necrosis factor (TNF) and interferon gamma (IFN-gamma). |
3(0,0,0,3) | Details |
| 19465080 | Omura S, Koike E, Kobayashi T: Microarray analysis of gene expression in rat alveolar epithelial cells exposed to fractionated organic extracts of diesel exhaust particles. Toxicology. 2009 Jul 28;262(1):65-72. Epub 2009 May 22. DMSF predominantly up-regulated genes associated with drug metabolism (Cyp1a1, Gsta3), oxidative stress response (HO-1, Srxn1) and cell cycle/apoptosis (Okl38). |
2(0,0,0,2) | Details |
| 15808651 | Martins PN, Reuzel-Selke A, Jurisch A, Atrott K, Pascher A, Pratschke J, Buelow R, Neuhaus P, Volk HD, Tullius SG: Induction of in the donor reduces graft immunogenicity and chronic graft deterioration. Transplant Proc. 2005 Jan-Feb;37(1):379-81. One of these genes that has been shown to mediate protective effects decodes the enzyme heme oxygenase-1 (HO-1), and an HO-1 downstream product, (CO). Using an established model of kidney chronic allograft rejection in the rat, we investigated the impact of methylene chloride (MC), a CO donor, as a therapeutic tool to reduce chronic graft deterioration. |
1(0,0,0,1) | Details |
| 15916789 | Koike E, Kobayashi T: Organic extract of diesel exhaust particles stimulates expression of Ia and costimulatory molecules associated with antigen presentation in rat peripheral blood monocytes but not in alveolar macrophages. Toxicol Appl Pharmacol. 2005 Dec 15;209(3):277-85. When the induction of an antioxidative enzyme was assessed, heme oxygenase-1 protein was found to be significantly increased by exposure to whole DEP, and the organic extract was more effective than the residual particles. DEP was extracted with methylene chloride. |
1(0,0,0,1) | Details |