Protein Information

Name heme oxygenase 1
Synonyms HMOX 1; HMOX1; HMOX1 protein; HO; HO 1; HO1; Heme oxygenase (Decycling) 1; Heme oxygenase (Decyclizing) 1…

Compound Information

Name copper arsenate
CAS

Reference List

PubMed Abstract RScore(About this table)
17945439 Scharf B, Trombetta LD: The effects of the wood preservative copper dimethyldithiocarbamate in the hippocampus of maternal and newborn Long-Evans rats. Toxicol Lett. 2007 Nov 1;174(1-3):117-24. Epub 2007 Sep 14.

The potential toxic effects on human health and deleterious effects to the environment by copper dimethyldithiocarbamate (CDDC), an alternative wood preservative to chromated copper arsenate (CCA) have not been investigated.
Western blot analysis revealed an induction of stress proteins HO-1 and Hsp70 and the formation of 4-hydroxy-2-nonenal (4HNE) adducts.
1(0,0,0,1) Details
19895865 Tajima H, Yoshida T, Ohnuma A, Fukuyama T, Hayashi K, Yamaguchi S, Ohtsuka R, Sasaki J, Tomita M, Kojima S, Takahashi N, Kashimoto Y, Kuwahara M, Takeda M, Kosaka T, Nakashima N, Harada T: Pulmonary injury and antioxidant response in mice exposed to arsenate and hexavalent chromium and their combination. Toxicology. 2010 Jan 12;267(1-3):118-24. Epub 2009 Nov 4.

Expressed mRNA levels of heme oxygenase-1, glutamylcysteine ligase, glutathione peroxidase 2, thioredoxin (TRX) 1, and TRXRD1 were also enhanced by co-treatment, whereas treatment with As (V) alone reduced the mRNA expression level of TRX2.
Chromated copper arsenate, which is used worldwide as a wood preservative, can adversely affect human health.
1(0,0,0,1) Details