Protein Information

Name osteocalcin
Synonyms BGLAP; BGP; Bone Gla protein; Bone gamma carboxyglutamaic acid protein; Gamma carboxyglutamicacid protein; Gamma carboxyglutamic acid containing protein; Osteocalcin; Osteocalcin precursor…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19436947 Rothem DE, Rothem L, Soudry M, Dahan A, Eliakim R: Nicotine modulates bone metabolism-associated gene expression in osteoblast cells. J Bone Miner Metab. 2009;27(5):555-61. Epub 2009 May 13.

To identify possible mechanisms underlying nicotine-induced changes in osteogenic metabolism, we defined changes in proliferation and osteocalcin, type I collagen, and alkaline phosphatase gene expression after treating human osteosarcoma cells (MG63), with various concentration of nicotine.
87(1,1,2,2) Details
19656028 Lee HJ, Pi SH, Kim Y, Kim HS, Kim SJ, Kim YS, Lee SK, Kim EC: Effects of nicotine on antioxidant defense enzymes and RANKL expression in human periodontal ligament cells. J Periodontol. 2009 Aug;80(8):1281-8.

RESULTS: Nicotine treatment concomitantly downregulated the expression of OPG and osteoblastic differentiation markers, such as alkaline phosphatase, osteocalcin, and osteopontin, and upregulated the expression of RANKL.
6(0,0,1,1) Details
19927714 Bai B, Zhong LF, Zhu JT: [Nicotine affects biological properties of the human osteosarcoma cell line MG63]. Hua Xi Kou Qiang Yi Xue Za Zhi. 2009 Oct;27(5):483-6.

The expression of collagen type I (COL1) and osteocalcin (OCN) were estimated by reverse transcription-polymerase chain reaction (RT-PCR).
1(0,0,0,1) Details