| Name | CHRNA4 |
|---|---|
| Synonyms | BFNC; EBN; EBN 1; EBN1; CHRNA 4; CHRNA4; NACRA 4; NACRA4… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19482438 | Etter JF, Hoda JC, Perroud N, Munafo M, Buresi C, Duret C, Neidhart E, Malafosse A, Bertrand D: Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence. Addict Behav. 2009 Sep;34(9):772-5. Epub 2009 May 22. levels were higher in carriers of the CC genotype of CHRNA4 rs1044396 (371 ng/ml) than in those with the CT or TT genotypes (275 ng/ml, p=0.049), a difference of 0.53 standard deviation units. |
1(0,0,0,1) | Details |
| 19693267 | Roe BE, Tilley MR, Gu HH, Beversdorf DQ, Sadee W, Haab TC, Papp AC: Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene. PLoS One. 2009 Aug 20;4(8):e6704. |
162(2,2,2,2) | Details |
| 20061993 | Wilking JA, Hesterberg KG, Crouch EL, Homanics GE, Stitzel JA: Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity. Pharmacogenet Genomics. 2010 Feb;20(2):121-30. However, one genetic variant has been implicated in altering nicotine sensitivity in mice is a T529A polymorphism in Chrna4, the gene that encodes the nicotinic receptor (nAChR) alpha4 subunit. |
45(0,1,3,5) | Details |
| 20331911 | Reinvang I, Lundervold AJ, Wehling E, Rootwelt H, Espeseth T: Epistasis between APOE and nicotinic receptor gene CHRNA4 in age related cognitive function and decline. J Int Neuropsychol Soc. 2010 Mar 24:1-9. The sample was genotyped for apolipoprotein E (APOE) and CHolinergic Receptor for Nicotine Alpha 4 (CHRNA4), and genetic effects on cognitive function at initial testing and on cognitive decline was studied. |
35(0,1,1,5) | Details |
| 19301390 | Ackerman KM, Nakkula R, Zirger JM, Beattie CE, Boyd RT: Cloning and spatiotemporal expression of zebrafish neuronal nicotinic acetylcholine receptor alpha 6 and alpha 4 subunit RNAs. Dev Dyn. 2009 Apr;238(4):980-92. We are developing zebrafish (Danio rerio) as a model system to study the role of specific neuronal nicotinic acetylcholine receptor (nAChR) subtypes in development and the effects of nicotine on the developing vertebrate nervous system. To further develop the zebrafish model, here we report a study on the molecular characterization of two additional nAChR subunit genes, designated chrna6 and chrna4. |
5(0,0,0,5) | Details |
| 19020039 | Zhu G, Okada M, Yoshida S, Ueno S, Mori F, Takahara T, Saito R, Miura Y, Kishi A, Tomiyama M, Sato A, Kojima T, Fukuma G, Wakabayashi K, Hase K, Ohno H, Kijima H, Takano Y, Mitsudome A, Kaneko S, Hirose S: Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype. J Neurosci. 2008 Nov 19;28(47):12465-76. |
3(0,0,0,3) | Details |
| 19290018 | Breitling LP, Dahmen N, Mittelstrass K, Rujescu D, Gallinat J, Fehr C, Giegling I, Lamina C, Illig T, Muller H, Raum E, Rothenbacher D, Wichmann HE, Brenner H, Winterer G: Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans. Pharmacogenomics J. 2009 Aug;9(4):219-24. Epub 2009 Mar 17. Polymorphisms in the CHRNA4 gene coding the nicotinic acetylcholine receptor subunit alpha 4 have recently been suggested to play a role in the determination of smoking-related phenotypes. |
3(0,0,0,3) | Details |
| 19404753 | Cannata DJ, Finkelstein DI, Gantois I, Teper Y, Drago J, West JM: Altered fast- and slow-twitch muscle fibre characteristics in female mice with a (S248F) knock-in mutation of the brain neuronal nicotinic acetylcholine receptor. J Muscle Res Cell Motil. 2009;30(1-2):73-83. Epub 2009 Apr 29. We generated a mouse line with a missense mutation (S248F) in the gene (CHRNA4) encoding the alpha4 subunit of neuronal nicotinic acetylcholine receptor (nAChR). Mutant mice demonstrate brief nicotine induced dystonia that resembles the clinical events seen in patients with the same mutation. |
1(0,0,0,1) | Details |
| 19819424 | Han S, Gelernter J, Luo X, Yang BZ: Meta-analysis of 15 genome-wide linkage scans of smoking behavior. Biol Psychiatry. 2010 Jan 1;67(1):12-9. Epub . Subgroup analysis of MaxCigs24 (966 families with 3273 subjects) identified a genome-wide significant linkage in 20q13.12-q13.32 (p (SR) = .00041, p (OR) = .048), where a strongly supported nicotine dependence candidate gene, CHRNA4, is located. |
1(0,0,0,1) | Details |
| 19698703 | Landgren S, Engel JA, Andersson ME, Gonzalez-Quintela A, Campos J, Nilsson S, Zetterberg H, Blennow K, Jerlhag E: Association of nAChR gene haplotypes with heavy alcohol use and body mass. Brain Res. 2009 Dec 11;1305 Suppl:S72-9. Epub 2009 Aug 19. Therefore the aim was to investigate nicotine receptor subunit genes in a haplotype study of use. Moreover, one haplotype of the CHRNA4 (GGTG) was associated with increased body weight as compared to non-carriers of this haplotype, especially in the heavy consumers of (p=0.004).The present findings are the first to disclose a haplotype association between the CHRNA6 gene and heavy alcohol use as well as an association of the CHRNA4 gene with increased body mass in heavy consumers of |
1(0,0,0,1) | Details |
| 19628475 | Sabatelli M, Eusebi F, Al-Chalabi A, Conte A, Madia F, Luigetti M, Mancuso I, Limatola C, Trettel F, Sobrero F, Di Angelantonio S, Grassi F, Di Castro A, Moriconi C, Fucile S, Lattante S, Marangi G, Murdolo M, Orteschi D, Del Grande A, Tonali P, Neri G, Zollino M: Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis. Hum Mol Genet. 2009 Oct 15;18(20):3997-4006. Epub 2009 Jul 23. Since neuronal acetylcholine receptors (nAChRs) are part of the glutamatergic pathway, we searched for sequence variants in CHRNA3, CHRNA4 and CHRNB4 genes, encoding neuronal nicotinic AChR subunits, in 245 SALS patients and in 450 controls. NAChRs formed by mutant alpha3 and alpha4 and wild-type (WT) beta4 subunits exhibited altered affinity for nicotine (Nic), reduced use-dependent rundown of Nic-activated currents (I (Nic)) and reduced desensitization leading to sustained intracellular Ca (2+) concentration, in comparison with WT-nAChR. |
1(0,0,0,1) | Details |
| 19259974 | Saccone NL, Saccone SF, Hinrichs AL, Stitzel JA, Duan W, Pergadia ML, Agrawal A, Breslau N, Grucza RA, Hatsukami D, Johnson EO, Madden PA, Swan GE, Wang JC, Goate AM, Rice JP, Bierut LJ: Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am J Med Genet B Neuropsychiatr Genet. 2009 Jun 5;150B(4):453-66. To detect and characterize the influence of genetic variation on vulnerability to nicotine dependence, we analyzed 226 SNPs covering the complete family of 16 CHRN genes, which encode the nicotinic acetylcholine receptor (nAChR) subunits, in a sample of 1,050 nicotine-dependent cases and 879 non-dependent controls of European descent. Nominally significant single-SNP association was detected in CHRNA4 and CHRNB1. |
1(0,0,0,1) | Details |
| 19383498 | Hoda JC, Wanischeck M, Bertrand D, Steinlein OK: Pleiotropic functional effects of the first epilepsy-associated mutation in the human CHRNA2 gene. FEBS Lett. 2009 May 19;583(10):1599-604. Epub 2009 Apr 19. Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) can be caused by mutations in the neuronal nicotinic acetylcholine receptor (nAChR) subunit genes CHRNA4 and CHRNB2. We demonstrate here that alpha2-I279N can be co-expressed with the major structural subunit CHRNB2. alpha2-I279N causes a marked gain-of-function effect and displays a distinct biopharmacological profile, including markedly reduced inhibition by carbamazepine and increased nicotine sensitivity. |
1(0,0,0,1) | Details |