| Name | ND1 |
|---|---|
| Synonyms | MT ND1; ND1; MTND 1; MTND1; NADH dehydrogenase 1; NADH dehydrogenase subunit 1; NADH ubiquinone oxidoreductase chain 1; mitochondrially encoded NADH dehydrogenase 1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1959619 | Majander A, Huoponen K, Savontaus ML, Nikoskelainen E, Wikstrom M: Electron transfer properties of NADH:ubiquinone reductase in the ND1/3460 and the ND4/11778 mutations of the Leber hereditary optic neuroretinopathy (LHON). FEBS Lett. 1991 Nov 4;292(1-2):289-92. The ND1/3460 mutation exhibits 80% reduction in rotenone-sensitive and -dependent electron transfer activity, whereas the proximal NADH dehydrogenase activity of the Complex is unaffected. |
164(2,2,2,4) | Details |
| 17474759 | Murai M, Ishihara A, Nishioka T, Yagi T, Miyoshi H: The ND1 subunit constructs the inhibitor binding domain in bovine heart mitochondrial complex I. Biochemistry. 2007 May 29;46(21):6409-16. Epub 2007 May 3. A variety of complex I inhibitors such as piericidin A and rotenone efficiently suppressed the specific binding of [125I] TDA to ND1, indicating that they share a common binding domain. |
84(1,1,1,4) | Details |
| 15950924 | Mus F, Cournac L, Cardettini V, Caruana A, Peltier G: Inhibitor studies on non-photochemical plastoquinone reduction and H (2) photoproduction in Chlamydomonas reinhardtii. Biochim Biophys Acta. 2005 Jul 15;1708(3):322-32. Based on the insensitivity of these reactions to rotenone, a type-I NADH dehydrogenase (NDH-1) inhibitor, and their sensitivity to flavoenzyme inhibitors and thiol blocking agents, we conclude to the involvement of a type-II NADH dehydrogenase (NDH-2) in PQ reduction. |
31(0,1,1,1) | Details |
| 9191778 | Carelli V, Ghelli A, Ratta M, Bacchilega E, Sangiorgi S, Mancini R, Leuzzi V, Cortelli P, Montagna P, Lugaresi E, Degli Esposti M: Leber's hereditary optic neuropathy: biochemical effect of 11778/ND4 and 3460/ND1 mutations and correlation with the mitochondrial genotype. Neurology. 1997 Jun;48(6):1623-32. In platelets homoplasmic for mutant mtDNA, both 11778/ND4 and 3460/ND1 mutations induced resistance to rotenone and the 3460/ND1 mutation also provoked a marked decrease in the specific activity of complex I. |
8(0,0,1,3) | Details |
| 9266534 | Ghelli A, Degli Esposti M, Carelli V, Lenaz G: Changes in mitochondrial complex I activity and binding site in Leber's hereditary optic neuropathy (LHON). Mol Aspects Med. 1997;18 Suppl:S263-7. Both 11778/ND4 and 3460/ND1 mutations induced rotenone resistance and 11778/ND4 showed an increased K (m) for -2 with respect to the control group. |
7(0,0,1,2) | Details |
| 3378042 | Yagi T, Hon-nami K, Ohnishi T: Purification and characterization of two types of -quinone reductase from Thermus thermophilus HB-8. Biochemistry. 1988 Mar 22;27(6):2008-13. The - reductase activity of the isolated NADH dehydrogenase 1 was about 14 times higher than that of the dodecyl beta-maltoside extract and partially rotenone sensitive. |
8(0,0,1,3) | Details |
| 18235013 | Ghelli A, Porcelli AM, Zanna C, Martinuzzi A, Carelli V, Rugolo M: Protection against oxidant-induced apoptosis by exogenous in Leber hereditary optic neuropathy cybrids. Invest Ophthalmol Vis Sci. 2008 Feb;49(2):671-6. METHODS: Cybrids bearing one of the three most common LHON pathogenic mutations (11778/ND4, 3460/ND1, 14484/ND6) were incubated with two compounds known to induce oxidative injury, tert-butyl hydroperoxide (t-BH) and rotenone. |
6(0,0,1,1) | Details |
| 11418099 | Schuler F, Casida JE: Functional coupling of PSST and ND1 subunits in NADH:ubiquinone oxidoreductase established by photoaffinity labeling. Biochim Biophys Acta. 2001 Jul 2;1506(1):79-87. |
5(0,0,0,5) | Details |
| 9718301 | Zickermann V, Barquera B, Wikstrom M, Finel M: Analysis of the pathogenic human mitochondrial mutation ND1/3460, and mutations of strictly conserved residues in its vicinity, using the bacterium Paracoccus denitrificans. Biochemistry. 1998 Aug 25;37(34):11792-6. The enzymatic activity of the mutants in the presence of hexammineruthenium (rotenone-insensitive) and (rotenone-sensitive) were assayed. |
4(0,0,0,4) | Details |
| 15505787 | Valentino ML, Barboni P, Ghelli A, Bucchi L, Rengo C, Achilli A, Torroni A, Lugaresi A, Lodi R, Barbiroli B, Dotti M, Federico A, Baruzzi A, Carelli V: The ND1 gene of complex I is a mutational hot spot for Leber's hereditary optic neuropathy. Ann Neurol. 2004 Nov;56(5):631-41. Biochemical investigations in platelets showed partially insensitive complex I to rotenone inhibition. |
3(0,0,0,3) | Details |
| 18486613 | Zhang LQ, Adyshev DM, Singleton P, Li H, Cepeda J, Huang SY, Zou X, Verin AD, Tu J, Garcia JG, Ye SQ: Interactions between PBEF and oxidative stress proteins--a potential new mechanism underlying PBEF in the pathogenesis of acute lung injury. FEBS Lett. 2008 Jun 11;582(13):1802-8. Epub 2008 May 16. The interactions between PBEF and NADH dehydrogenase subunit 1 (ND1), ferritin light chain and interferon induced transmembrane 3 (IFITM3) in human pulmonary vascular endothelial cells were identified and validated. Overexpression of PBEF increased its interactions and intracellular oxidative stress, which can be attenuated by rotenone. |
3(0,0,0,3) | Details |
| 9831004 | Pezzi PP, De Negri AM, Sadun F, Carelli V, Leuzzi V: Childhood Leber's hereditary optic neuropathy (ND1/3460) with visual recovery. Pediatr Neurol. 1998 Oct;19(4):308-12. An abnormal resistance of NADH:ubiquinone reductase to the inhibitory effect of rotenone was found in platelet mitochondria from the proband and family members and was consistent with the degree of heteroplasmy. |
3(0,0,0,3) | Details |
| 12079358 | Cardol P, Matagne RF, Remacle C: Impact of mutations affecting ND mitochondria-encoded subunits on the activity and assembly of complex I in Chlamydomonas. J Mol Biol. 2002 Jun 21;319(5):1211-21. The mitochondrial rotenone-sensitive NADH:ubiquinone oxidoreductase (complex I) comprises more than 35 subunits, the majority of which are encoded by the nucleus. In Chlamydomonas reinhardtii, only five components (ND1, ND2, ND4, ND5 and ND6) are coded for by the mitochondrial genome. |
2(0,0,0,2) | Details |
| 16963630 | Cardol P, Lapaille M, Minet P, Franck F, Matagne RF, Remacle C: ND3 and ND4L subunits of mitochondrial complex I, both nucleus encoded in Chlamydomonas reinhardtii, are required for activity and assembly of the enzyme. Eukaryot Cell. 2006 Sep;5(9):1460-7. Made of more than 40 subunits, the rotenone-sensitive NADH:ubiquinone oxidoreductase (complex I) is the most intricate membrane-bound enzyme of the mitochondrial respiratory chain. In vascular plants, fungi, and animals, at least seven complex I subunits (ND1, -2, -3, -4, -4L, -5, and -6; ND is NADH dehydrogenase) are coded by mitochondrial genes. |
1(0,0,0,1) | Details |
| 15342361 | Beretta S, Mattavelli L, Sala G, Tremolizzo L, Schapira AH, Martinuzzi A, Carelli V, Ferrarese C: Leber hereditary optic neuropathy mtDNA mutations disrupt transport in cybrid cell lines. Brain. 2004 Oct;127(Pt 10):2183-92. Epub 2004 Sep 1. Three pathogenic mutations (positions 11778/ND4, 3460/ND1 and 14484/ND6) account for the majority of LHON cases and they affect genes that encode for different subunits of mitochondrial complex I. |
1(0,0,0,1) | Details |
| 10220277 | Konishi K, Tanaka T: Inhibitory effects of tannins on the NADH dehydrogenase activity of bovine heart mitochondrial complex I. Biol Pharm Bull. 1999 Mar;22(3):240-3. -quinone oxidoreductase is classified into two groups, NADH dehydrogenase-1 (NDH-1) and NADH dehydrogenase-2 (NDH-2). Although many specific inhibitors of NDH-1 (e.g. rotenone and piericidin A) have been reported, the reactive sites are at or near to, the -binding site. |
1(0,0,0,1) | Details |
| 19047048 | Porcelli AM, Angelin A, Ghelli A, Mariani E, Martinuzzi A, Carelli V, Petronilli V, Bernardi P, Rugolo M: Respiratory complex I dysfunction due to mitochondrial DNA mutations shifts the voltage threshold for opening of the permeability transition pore toward resting levels. J Biol Chem. 2009 Jan 23;284(4):2045-52. Epub 2008 Dec 1. We have studied mitochondrial bioenergetics in HL180 cells (a cybrid line harboring the T14484C/ND6 and G14279A/ND6 mtDNA mutations of Leber hereditary optic neuropathy, leading to an approximately 50% decrease of ATP synthesis) and XTC.UC1 cells (derived from a thyroid oncocytoma bearing a disruptive frameshift mutation in MT-ND1, which impairs complex I assembly). The addition of rotenone to HL180 cells and of antimycin A to XTC.UC1 cells caused fast mitochondrial membrane depolarization that was prevented by treatment with cyclosporin A, intracellular Ca2+ chelators, and antioxidant. |
1(0,0,0,1) | Details |
| 18615737 | Sala G, Trombin F, Beretta S, Tremolizzo L, Presutto P, Montopoli M, Fantin M, Martinuzzi A, Carelli V, Ferrarese C: Antioxidants partially restore transport defect in leber hereditary optic neuropathy cybrids. J Neurosci Res. 2008 Nov 15;86(15):3331-7. We used transmitochondrial cybrid cell lines constructed using enucleated fibroblasts from three LHON probands carrying the most severe 3460/ND1 mutation and three controls as mitochondria donors, and the osteosarcoma-derived mtDNA-less cells, to study the possible efficacy of two selected antioxidant compounds in preventing uptake reduction previously observed in LHON cybrids. Rotenone, a classic complex I inhibitor, did not worsen the uptake defect present in LHON cybrids under basal conditions but significantly reduced transport in control cybrids. |
1(0,0,0,1) | Details |
| 20074573 | Nakamaru-Ogiso E, Han H, Matsuno-Yagi A, Keinan E, Sinha SC, Yagi T, Ohnishi T: The ND2 subunit is labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor. FEBS Lett. 2010 Mar 5;584(5):883-8. Epub 2010 Jan 13. We found that [3H] BPA was photo-crosslinked to ND2, ND1 and ND5 subunits, by the three dimensional separation (blue-native/doubled SDS-PAGE) of [3H] BPA-treated bovine heart submitochondrial particles. The cross-linking was blocked by rotenone. |
1(0,0,0,1) | Details |
| 10426140 | Cock HR, Cooper JM, Schapira AH: Functional consequences of the 3460-bp mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. J Neurol Sci. 1999 May 1;165(1):10-7. We have confirmed an approximate 60% defect in mitochondrial CoQ1 reductase activity in cultured fibroblasts bearing the 3460-bp G to A mutation within the ND1 gene. A 60% rotenone-induced decrease in complex I activity was shown to reduce ATP synthesis in normal fibroblasts, indicating that this level of complex I activity was below the threshold required to affect ATP synthesis. |
1(0,0,0,1) | Details |
| 18781777 | Ichimaru N, Murai M, Kakutani N, Kako J, Ishihara A, Nakagawa Y, Nishioka T, Yagi T, Miyoshi H: Synthesis and characterization of new piperazine-type inhibitors for mitochondrial NADH-ubiquinone oxidoreductase (complex I). Biochemistry. 2008 Oct 7;47(40):10816-26. Epub 2008 Sep 10. The mode of action of Deltalac-acetogenins, strong inhibitors of bovine heart mitochondrial complex I, is different from that of traditional inhibitors such as rotenone and piericidin A [Murai, M., et al. (2007) Biochemistry 46 , 6409-6416]. |
0(0,0,0,0) | Details |
| 2050655 | Yagi T: Bacterial -quinone oxidoreductases. . J Bioenerg Biomembr. 1991 Apr;23(2):211-25. The - reductase activities of NDH-1 are inhibited by rotenone, and dicyclohexylcarbodiimide. |
0(0,0,0,0) | Details |
| 9603924 | Barrientos A, Kenyon L, Moraes CT: Human xenomitochondrial cybrids. J Biol Chem. 1998 Jun 5;273(23):14210-7. Rotenone inhibition studies of intact cell respiration and - oxidation in permeabilized cells showed that 3 nM rotenone produced a mild effect in control cells (0-10% inhibition) but produced a marked inhibition of HXC respiration (50-75%). |
0(0,0,0,0) | Details |