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rotenone

Identification (Source:EPA,EU)

ID	1341
Name	rotenone
CAS	83-79-4
IUPAC
Inchi	InChI=1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1
CIPAC	38
EPA Code	071003
Formula	C23H22O6
SMILES	O=C2c5ccc1OC(C(=C)\C)Cc1c5OC3C2c4c(OC3)cc(OC)c(OC)c4
Status	Not Approved

Classification

Mode of Action	Selective, non-systemic with contact and stomach action. Mitochondrial complex I electron transport inhibitor.
Pesticide Type	Insecticide, Acaricide, Veterinary treatment
Chemical Group	Plant derived
Classification	botanical insecticides

Properties (Source:PubChem)

Molecular Weight	394.42
Physical State	White powder
AlogP	3.93
H-Bond Donor	0
H-Bond Acceptor	6
Surface Area	361.18
Polar Surface Area	63.22

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	0.6 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.004 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.001 mg l-1
Birds	Acute		LD50	2000 mg kg-1
Birds	Acute		LD50	2000 mg kg-1
Fish	Acute	96 hour	LC50	0.0019 mg l-1
Fish	Chronic	21 day	NOEC	0.0012 mg l-1
Honeybees	Acute	48 hour	LD50	0.24 μg bee-1
Mammals	Acute oral		LD50	> 132 mg kg-1
Mammals	Acute oral		LD50	> 132 mg kg-1
Mammals	Short term dietary		NOEL	10 mg kg-1
Mammals	Short term dietary		NOEL	10 mg kg-1
	Bio-concentration factor		CT50	Not available days
	Bio-concentration factor		CT50	Not available days
	Bio-concentration factor		BCF	26
	Bio-concentration factor		BCF	26

Related targets

Target Name	RScore (About this table)
complex I	25850(195,471,537,1640)	Details
NADH dehydrogenase	3903(28,68,103,288)	Details
cytochrome c	4398(20,83,171,468)	Details
caspase 3	1516(12,26,29,121)	Details
p38	1406(12,24,25,81)	Details
alpha synuclein	1822(11,29,66,217)	Details
NADH:ubiquinone oxidoreductase (protein family or complex)	1461(9,26,39,166)	Details
caspase (protein family or complex)	1111(8,19,25,111)	Details
cytochrome b	836(7,13,17,76)	Details
ubiquinone reductase	796(6,14,18,56)	Details
bcl 2	662(6,8,14,92)	Details
MAPK (protein family or complex)	720(5,13,13,80)	Details
malate dehydrogenase	502(5,7,8,37)	Details
catalase	706(4,11,22,121)	Details
ERK1	506(4,9,9,36)	Details
tyrosine hydroxylase	598(4,8,27,63)	Details
c jun	432(4,7,7,22)	Details
monoamine transporter	364(4,5,6,9)	Details
Cytochrome c oxidase (protein family or complex)	639(3,12,20,89)	Details
mitochondrial ATPase	496(3,10,10,46)	Details
IL 1	373(3,6,7,38)	Details
phosphatidylinositol 3 kinase (protein family or complex)	358(3,6,6,28)	Details
glucose transporter 1	356(3,6,6,26)	Details
Potassium channel (protein family or complex)	341(3,5,9,21)	Details
caspase 9	340(3,5,6,35)	Details
ferritin (protein family or complex)	322(3,5,6,17)	Details
ND1	335(3,4,8,45)	Details
hexokinase	311(3,4,5,36)	Details
NF kappa B	294(3,4,4,24)	Details
endothelin 1	294(3,4,5,19)	Details
peroxisome proliferator activated receptor	264(3,3,3,24)	Details
cyclin D1	252(3,3,3,12)	Details
PERK	247(3,3,3,7)	Details
succinate dehydrogenase (protein family or complex)	622(2,14,20,72)	Details
ATPase	648(2,12,15,173)	Details
superoxide dismutase	476(2,7,16,121)	Details
dopamine transporter	325(2,6,10,25)	Details
TNFalpha	296(2,4,4,76)	Details
diaphorase	271(2,4,6,41)	Details
AMPK	268(2,4,4,48)	Details
PI3K	261(2,4,4,41)	Details
PARP	234(2,4,4,14)	Details
RANKL	232(2,4,5,7)	Details
c Jun N terminal kinase (protein family or complex)	231(2,4,4,11)	Details
DJ 1	302(2,3,12,67)	Details
ornithine decarboxylase	209(2,3,3,19)	Details
Connexin 43	197(2,3,3,7)	Details
LRRK2	215(2,2,6,35)	Details
metallothionein (protein family or complex)	189(2,2,4,19)	Details
interferon gamma	177(2,2,2,17)	Details
glyceraldehyde 3 phosphate dehydrogenase	174(2,2,3,9)	Details
Ciliary neurotrophic factor	168(2,2,2,8)	Details
ubiquitin	385(1,8,17,50)	Details
Calpains (protein family or complex)	319(1,8,9,24)	Details
quinone reductase	380(1,6,22,70)	Details
monoamine oxidase	245(1,4,11,40)	Details
citrate synthase	205(1,4,6,25)	Details
Cox 2	179(1,4,4,9)	Details
NA K ATPase	203(1,3,7,43)	Details
brain derived neurotrophic factor	166(1,3,5,16)	Details
aldehyde dehydrogenase (protein family or complex)	157(1,3,3,17)	Details
Hexokinase II	156(1,3,4,11)	Details
cAMP dependent protein kinase (protein family or complex)	149(1,3,3,9)	Details
NFATc1	143(1,3,3,3)	Details
pyruvate dehydrogenase (protein family or complex)	176(1,2,4,56)	Details
angiotensin II	174(1,2,6,44)	Details
heme oxygenase 1	159(1,2,4,39)	Details
glucagon	148(1,2,2,38)	Details
apoptosis inducing factor	138(1,2,5,13)	Details
transferase	133(1,2,2,23)	Details
glutathione reductase	133(1,2,3,18)	Details
bradykinin	131(1,2,2,21)	Details
alpha ketoglutarate dehydrogenase	128(1,2,2,18)	Details
EDRF	128(1,2,2,18)	Details
ND2	126(1,2,3,11)	Details
AP 1 (protein family or complex)	126(1,2,2,16)	Details
glucose transporter 4	121(1,2,2,11)	Details
AP 4	120(1,2,3,5)	Details
microtubule associated proteins	117(1,2,2,7)	Details
glutamate receptors (protein family or complex)	117(1,2,2,7)	Details
cytochrome bc1	116(1,2,2,6)	Details
insulin like growth factor I	115(1,2,2,5)	Details
Q10	115(1,2,2,5)	Details
estrogen receptor	113(1,2,2,3)	Details
pyrophosphatase	113(1,2,2,3)	Details
NADH cytochrome b5 reductase	118(1,1,5,18)	Details
albumin	116(1,1,3,26)	Details
fibronectin	105(1,1,1,25)	Details
NADH coenzyme Q reductase	104(1,1,3,14)	Details
annexin V	102(1,1,2,17)	Details
myoglobin	96(1,1,1,16)	Details
vascular endothelial growth factor	95(1,1,1,15)	Details
P glycoprotein	95(1,1,1,15)	Details
Synphilin 1	95(1,1,2,10)	Details
APAF 1	94(1,1,2,9)	Details
Siglec 8	94(1,1,1,14)	Details
proton pump	92(1,1,1,12)	Details
hemoglobin (protein family or complex)	92(1,1,1,12)	Details
NFkappaB (protein family or complex)	92(1,1,1,12)	Details
ICAM 1	89(1,1,1,9)	Details
Nerve growth factor	89(1,1,2,4)	Details
pepsinogen	89(1,1,1,9)	Details
interleukin (protein family or complex)	89(1,1,1,9)	Details
cytochrome c1	88(1,1,2,3)	Details
thioredoxin	88(1,1,1,8)	Details
aspartate aminotransferase	88(1,1,1,8)	Details
CD13	87(1,1,2,2)	Details
BCAA	87(1,1,1,7)	Details
BCL2 associated X protein	87(1,1,2,2)	Details
phospholipase C	87(1,1,1,7)	Details
P2X2	87(1,1,1,7)	Details
CD38	87(1,1,2,2)	Details
TonEBP	86(1,1,1,6)	Details
PARK 2	86(1,1,1,6)	Details
IL 6	86(1,1,1,6)	Details
TFAM	85(1,1,1,5)	Details
calcineurin (protein family or complex)	85(1,1,1,5)	Details
AMPH	85(1,1,1,5)	Details
E cadherin	84(1,1,1,4)	Details
glutathione peroxidase 1	84(1,1,1,4)	Details
immunoglobulin (protein family or complex)	84(1,1,1,4)	Details
PP1	84(1,1,1,4)	Details
caspase activated DNase	84(1,1,1,4)	Details
GTPase	83(1,1,1,3)	Details
Lactoferrin	83(1,1,1,3)	Details
neurotrophic factor	83(1,1,1,3)	Details
PPRibP	83(1,1,1,3)	Details
hydroxyacyl CoA dehydrogenase	83(1,1,1,3)	Details
D lactate dehydrogenase	83(1,1,1,3)	Details
HIF 1	82(1,1,1,2)	Details
SRS	82(1,1,1,2)	Details
ARL2	82(1,1,1,2)	Details
DMPK	82(1,1,1,2)	Details
AT2	81(1,1,1,1)	Details
caspase 2	81(1,1,1,1)	Details
BGT1	81(1,1,1,1)	Details
St 4	81(1,1,1,1)	Details
protein tyrosine kinase	81(1,1,1,1)	Details
MOLT	81(1,1,1,1)	Details
TMPO	81(1,1,1,1)	Details
calcineurin inhibitor	81(1,1,1,1)	Details
Myx	81(1,1,1,1)	Details
ED1	81(1,1,1,1)	Details
xanthine oxidase	294(0,8,10,44)	Details
cytochrome P450 (protein family or complex)	167(0,4,5,42)	Details
basic fibroblast growth factor	126(0,4,4,6)	Details
NADH dehydrogenases (protein family or complex)	164(0,3,9,44)	Details
lactate dehydrogenase (protein family or complex)	156(0,3,7,46)	Details
NMDA receptors (protein family or complex)	118(0,3,3,28)	Details
Lipoxygenase (protein family or complex)	110(0,3,4,15)	Details
electron transfer flavoprotein ubiquinone oxidoreductase	108(0,3,4,13)	Details
dopamine D2 receptor	99(0,3,4,4)	Details
pituitary adenylate cyclase activating polypeptide	97(0,3,3,7)	Details
c fos	96(0,3,3,6)	Details
LHON	126(0,2,4,56)	Details
glial cell line derived neurotrophic factor	102(0,2,7,17)	Details
protein is	85(0,2,3,20)	Details
neurotrophic factors	78(0,2,4,8)	Details
PACAP	78(0,2,3,13)	Details
p160 ROCK	76(0,2,2,16)	Details
CoQ 1	75(0,2,2,15)	Details
glutamate receptor	74(0,2,2,14)	Details
c Src	71(0,2,2,11)	Details
Par 4	67(0,2,2,7)	Details
ubiquinol cytochrome c reductase (protein family or complex)	64(0,2,2,4)	Details
calpain inhibitor	63(0,2,2,3)	Details
14 3 3	62(0,2,2,2)	Details
muscles	77(0,1,3,37)	Details
CA1	67(0,1,4,22)	Details
brains	65(0,1,4,20)	Details
glutaminase	64(0,1,3,24)	Details
PINK1	64(0,1,3,24)	Details
aconitase	58(0,1,1,28)	Details
transferrin	57(0,1,2,22)	Details
CHOP	50(0,1,2,15)	Details
hypoxia inducible factor 1alpha	49(0,1,2,14)	Details
DCIP	48(0,1,3,8)	Details
glucose 6 phosphatase	47(0,1,3,7)	Details
PPAR gamma	46(0,1,1,16)	Details
MT 2	46(0,1,3,6)	Details
glutathione S transferase	45(0,1,3,5)	Details
EGFR	45(0,1,1,15)	Details
BACE1	45(0,1,1,15)	Details
VPS41	44(0,1,2,9)	Details
PHGPx	44(0,1,2,9)	Details
PK1	44(0,1,1,14)	Details
vascular cell adhesion molecule 1	44(0,1,1,14)	Details
calmodulin	43(0,1,1,13)	Details
ASK1	43(0,1,1,13)	Details
protein as	43(0,1,2,8)	Details
IL 10	42(0,1,1,12)	Details
cholecystokinin	41(0,1,1,11)	Details
angiopoietin 1	41(0,1,1,11)	Details
phospholipase A2	40(0,1,1,10)	Details
2 methyl branched chain acyl CoA dehydrogenase	40(0,1,2,5)	Details
leptin	39(0,1,1,9)	Details
3 beta hydroxysteroid dehydrogenase	39(0,1,2,4)	Details
Kir2.3	39(0,1,2,4)	Details
sulfonylurea receptor	38(0,1,1,8)	Details
MS2	37(0,1,2,2)	Details
NPPB	37(0,1,1,7)	Details
SNAP	37(0,1,1,7)	Details
glycogen synthase kinase 3	37(0,1,1,7)	Details
Proton pumps	36(0,1,1,6)	Details
interleukin 8	36(0,1,1,6)	Details
dihydroorotate dehydrogenase	35(0,1,1,5)	Details
VDAC	35(0,1,1,5)	Details
ALDH2	35(0,1,1,5)	Details
PBEF	35(0,1,1,5)	Details
ATF4	35(0,1,1,5)	Details
uncoupling protein 1	35(0,1,1,5)	Details
nucleolin	35(0,1,1,5)	Details
Interleukin 5	34(0,1,1,4)	Details
DAPK	34(0,1,1,4)	Details
Myosin	34(0,1,1,4)	Details
glutamate pyruvate transaminases	34(0,1,1,4)	Details
CREB	34(0,1,1,4)	Details
lactoperoxidase	33(0,1,1,3)	Details
dopa decarboxylase	33(0,1,1,3)	Details
nNOS	33(0,1,1,3)	Details
phosphate carrier	33(0,1,1,3)	Details
IP3R	33(0,1,1,3)	Details
nucleoside diphosphate kinase	32(0,1,1,2)	Details
SREBF1	32(0,1,1,2)	Details
U87	32(0,1,1,2)	Details
benzodiazepine receptor (protein family or complex)	32(0,1,1,2)	Details
alpha2 adrenoceptors (protein family or complex)	32(0,1,1,2)	Details
CHRS	32(0,1,1,2)	Details
Death associated protein	32(0,1,1,2)	Details
ATG5	31(0,1,1,1)	Details
myogenin	31(0,1,1,1)	Details
histamine H2 receptor	31(0,1,1,1)	Details
RF a	31(0,1,1,1)	Details
OSCAR	31(0,1,1,1)	Details
protein serine threonine kinase	31(0,1,1,1)	Details
metabotropic glutamate receptor 5	31(0,1,1,1)	Details
ATP synthase (protein family or complex)	31(0,1,1,1)	Details
g protein 1	31(0,1,1,1)	Details
glyoxalase II	31(0,1,1,1)	Details
slow type	31(0,1,1,1)	Details
GRP78	31(0,1,1,1)	Details
keratinocyte growth factors	31(0,1,1,1)	Details
STAT1	31(0,1,1,1)	Details
SR a	31(0,1,1,1)	Details
alkaline phosphatase	31(0,1,1,1)	Details
Beclin 1	31(0,1,1,1)	Details
Anas	31(0,1,1,1)	Details
IgE	31(0,1,1,1)	Details
beta hexosaminidase	31(0,1,1,1)	Details
5 HT3 receptor	31(0,1,1,1)	Details
ceases	31(0,1,1,1)	Details
methemoglobin	31(0,1,1,1)	Details
ND4	51(0,0,4,31)	Details
SOD1	47(0,0,3,32)	Details
cytochrome b 5	40(0,0,3,25)	Details
gp91 phox	32(0,0,3,17)	Details
protein kinase C (protein family or complex)	27(0,0,0,27)	Details
H ras	26(0,0,1,21)	Details
ND6	24(0,0,1,19)	Details
Bcl xL	22(0,0,1,17)	Details
survivin	21(0,0,0,21)	Details
Pigment epithelium derived factor	19(0,0,2,9)	Details
gamma tubulin (protein family or complex)	19(0,0,3,4)	Details
STAT3	17(0,0,1,12)	Details
PSST	17(0,0,0,17)	Details
Beta synuclein	17(0,0,2,7)	Details
p47phox	17(0,0,0,17)	Details
uncoupling protein 2	14(0,0,1,9)	Details
NDUFA1	14(0,0,1,9)	Details
Vascular endothelial growth factor B	13(0,0,1,8)	Details
choline acetyltransferase	13(0,0,2,3)	Details
CA3	13(0,0,2,3)	Details
C18	13(0,0,1,8)	Details
isocitrate dehydrogenase	13(0,0,0,13)	Details
arylsulfatase	13(0,0,2,3)	Details
IkappaBalpha	13(0,0,0,13)	Details
glial fibrillary acidic protein	13(0,0,1,8)	Details
PC 3	12(0,0,0,12)	Details
p22 phox	12(0,0,0,12)	Details
CD133	11(0,0,0,11)	Details
p47 phox	11(0,0,0,11)	Details
neuronatin	11(0,0,1,6)	Details
GADD153	11(0,0,1,6)	Details
inducible NO synthase	11(0,0,1,6)	Details
kynurenine 3 hydroxylase	11(0,0,1,6)	Details
MELAS	10(0,0,0,10)	Details
thymoma	10(0,0,1,5)	Details
alcohol dehydrogenase (protein family or complex)	10(0,0,1,5)	Details
cholinephosphotransferase	10(0,0,1,5)	Details
hypoxia inducible factor 1 (protein family or complex)	10(0,0,0,10)	Details
p67 phox	10(0,0,0,10)	Details
apelin	10(0,0,0,10)	Details
heat shock factor 1	10(0,0,1,5)	Details
ferrochelatase	10(0,0,1,5)	Details
ceruloplasmin	9(0,0,1,4)	Details
adenylate cyclase	9(0,0,0,9)	Details
ND5	9(0,0,0,9)	Details
phosphodiesterase	9(0,0,0,9)	Details
c Myc	9(0,0,1,4)	Details
HSP27	8(0,0,1,3)	Details
glutathione transferase	8(0,0,1,3)	Details
beta glucuronidase	8(0,0,1,3)	Details
acetylcholine receptor (protein family or complex)	8(0,0,1,3)	Details
BCS1	8(0,0,1,3)	Details
NDH2	8(0,0,1,3)	Details
STIM1	8(0,0,0,8)	Details
mammalian target of rapamycin	8(0,0,0,8)	Details
CCL16	8(0,0,1,3)	Details
thrombin	8(0,0,0,8)	Details
phenol sulfotransferase	8(0,0,0,8)	Details
ClC 2	8(0,0,0,8)	Details
NAGA	8(0,0,1,3)	Details
novel proteins	8(0,0,1,3)	Details
phosphoenolpyruvate carboxykinase	7(0,0,0,7)	Details
Hsp90	7(0,0,0,7)	Details
alpha tubulin	7(0,0,1,2)	Details
guanylate cyclase	7(0,0,0,7)	Details
CD8	7(0,0,0,7)	Details
MAP2	7(0,0,1,2)	Details
ATG12	7(0,0,0,7)	Details
RTP801	7(0,0,0,7)	Details
DARPP 32	7(0,0,0,7)	Details
N myristoyltransferase	7(0,0,1,2)	Details
SULT2A1	7(0,0,0,7)	Details
huntingtin	7(0,0,0,7)	Details
MT1B	7(0,0,1,2)	Details
dihydrofolate reductase	7(0,0,0,7)	Details
G6PD	7(0,0,0,7)	Details
LAT1	7(0,0,1,2)	Details
PH3	7(0,0,0,7)	Details
prion protein	7(0,0,0,7)	Details
beta actin	6(0,0,1,1)	Details
integrin	6(0,0,0,6)	Details
factor is	6(0,0,0,6)	Details
CD95	6(0,0,0,6)	Details
DTNB	6(0,0,0,6)	Details
chymotrypsin like	6(0,0,1,1)	Details
thioredoxin reductase	6(0,0,0,6)	Details
calbindin	6(0,0,1,1)	Details
arylesterase	6(0,0,1,1)	Details
GF1	6(0,0,1,1)	Details
3 hydroxy 3 methylglutaryl coenzyme A reductase	6(0,0,0,6)	Details
phosphoinositide 3 kinase (protein family or complex)	6(0,0,0,6)	Details
TFEC	6(0,0,0,6)	Details
pyridine nucleotide transhydrogenase	6(0,0,0,6)	Details
CEF1	6(0,0,0,6)	Details
ornithine aminotransferase	6(0,0,0,6)	Details
MFGM	6(0,0,0,6)	Details
SIRT1	6(0,0,0,6)	Details
SIAH 1	6(0,0,1,1)	Details
HCl 2	6(0,0,1,1)	Details
sPLA 2	6(0,0,0,6)	Details
equilibrative nucleoside transporter 2	6(0,0,0,6)	Details
A11	6(0,0,1,1)	Details
glutamic dehydrogenase	6(0,0,1,1)	Details
metallothionein II	6(0,0,1,1)	Details
PDX1	6(0,0,0,6)	Details
THIK 1	6(0,0,0,6)	Details
dorfin	6(0,0,1,1)	Details
mortalin	5(0,0,0,5)	Details
ET A	5(0,0,0,5)	Details
1 alpha hydroxylase	5(0,0,0,5)	Details
ASNS	5(0,0,0,5)	Details
iron regulatory protein 2	5(0,0,0,5)	Details
hFis1	5(0,0,0,5)	Details
NARP	5(0,0,0,5)	Details
acyl CoA dehydrogenases	5(0,0,0,5)	Details
NF E2 related factor 2	5(0,0,0,5)	Details
SERCA3	5(0,0,0,5)	Details
uncoupling protein 3	5(0,0,0,5)	Details
PARP 1	5(0,0,0,5)	Details
adiponectin	5(0,0,0,5)	Details
HDAC	5(0,0,0,5)	Details
monocyte chemoattractant protein 1	5(0,0,0,5)	Details
JNK1	5(0,0,0,5)	Details
TIMP 2	5(0,0,0,5)	Details
Angiopoietin 2	5(0,0,0,5)	Details
vimentin	5(0,0,0,5)	Details
erythropoietin	5(0,0,0,5)	Details
PP2A	5(0,0,0,5)	Details
epidermal growth factor	5(0,0,0,5)	Details
FAAH	5(0,0,0,5)	Details
CIP1	5(0,0,0,5)	Details
glucose 6 phosphate dehydrogenase	5(0,0,0,5)	Details
Acetylcholinesterase	5(0,0,0,5)	Details
caspase 8	5(0,0,0,5)	Details
voltage dependent anion channel	5(0,0,0,5)	Details
c Raf	4(0,0,0,4)	Details
Atrial natriuretic peptide	4(0,0,0,4)	Details
spinocerebellar ataxia 12	4(0,0,0,4)	Details
activator protein 2	4(0,0,0,4)	Details
DRP1	4(0,0,0,4)	Details
NDUFS4	4(0,0,0,4)	Details
serine threonine kinase	4(0,0,0,4)	Details
microtubule associated protein tau	4(0,0,0,4)	Details
transient receptor potential melastatin 7	4(0,0,0,4)	Details
Tie 2	4(0,0,0,4)	Details
endonuclease G	4(0,0,0,4)	Details
ATPase is	4(0,0,0,4)	Details
P35	4(0,0,0,4)	Details
AD4	4(0,0,0,4)	Details
cytosolic malate dehydrogenase	4(0,0,0,4)	Details
TYKY	4(0,0,0,4)	Details
pyruvate carboxylase	4(0,0,0,4)	Details
mitochondrial benzodiazepine receptor	4(0,0,0,4)	Details
endothelial nitric oxide synthase	4(0,0,0,4)	Details
ADH1	4(0,0,0,4)	Details
aldose reductase	4(0,0,0,4)	Details
mMDH	4(0,0,0,4)	Details
protein phosphatase 2A (protein family or complex)	4(0,0,0,4)	Details
PTEN	4(0,0,0,4)	Details
cyclophilin D	4(0,0,0,4)	Details
calcium channel (protein family or complex)	4(0,0,0,4)	Details
beta adrenergic receptors (protein family or complex)	4(0,0,0,4)	Details
MEK1	4(0,0,0,4)	Details
aryl hydrocarbon hydroxylase	4(0,0,0,4)	Details
Substance P	4(0,0,0,4)	Details
parathormone	4(0,0,0,4)	Details
transcription factor E2F	3(0,0,0,3)	Details
formaldehyde dehydrogenase	3(0,0,0,3)	Details
p47	3(0,0,0,3)	Details
ERp57	3(0,0,0,3)	Details
ND4L	3(0,0,0,3)	Details
BP12	3(0,0,0,3)	Details
Nup214	3(0,0,0,3)	Details
sequestosome 1	3(0,0,0,3)	Details
dipeptidylpeptidase 3	3(0,0,0,3)	Details
calnexin	3(0,0,0,3)	Details
NOX4	3(0,0,0,3)	Details
excitatory amino acid transporter 1	3(0,0,0,3)	Details
XIAP	3(0,0,0,3)	Details
organic cation transporter 3	3(0,0,0,3)	Details
phosphatidate phosphohydrolase	3(0,0,0,3)	Details
ND3	3(0,0,0,3)	Details
fumarase	3(0,0,0,3)	Details
ICAD	3(0,0,0,3)	Details
N acetyl beta glucosaminidase	3(0,0,0,3)	Details
Amyloid beta protein	3(0,0,0,3)	Details
DLDH	3(0,0,0,3)	Details
protein kinase B	3(0,0,0,3)	Details
histone deacetylases (protein family or complex)	3(0,0,0,3)	Details
cyclin dependent kinase (protein family or complex)	3(0,0,0,3)	Details
p50	3(0,0,0,3)	Details
SM2	3(0,0,0,3)	Details
Iron regulatory protein 1	3(0,0,0,3)	Details
beta is	3(0,0,0,3)	Details
sulfotransferases (protein family or complex)	3(0,0,0,3)	Details
metalloproteinase	3(0,0,0,3)	Details
RAGE	3(0,0,0,3)	Details
dynamin (protein family or complex)	3(0,0,0,3)	Details
statins	3(0,0,0,3)	Details
Kir6.2	3(0,0,0,3)	Details
protein tyrosine phosphatase	3(0,0,0,3)	Details
CD14	3(0,0,0,3)	Details
glucocorticoid receptors	3(0,0,0,3)	Details
phosphofructokinase	3(0,0,0,3)	Details
organic cation transporter	3(0,0,0,3)	Details
chloride channel (protein family or complex)	3(0,0,0,3)	Details
CYP19	3(0,0,0,3)	Details
acid phosphatase	3(0,0,0,3)	Details
Hsp70	3(0,0,0,3)	Details
PCNA	3(0,0,0,3)	Details
cathepsin D	3(0,0,0,3)	Details
per 1	3(0,0,0,3)	Details
beta catenin	3(0,0,0,3)	Details
aminopeptidase	3(0,0,0,3)	Details
somatostatin	3(0,0,0,3)	Details
demethylase	3(0,0,0,3)	Details
glycine decarboxylase	3(0,0,0,3)	Details
IDDM	2(0,0,0,2)	Details
RNase	2(0,0,0,2)	Details
kinesin	2(0,0,0,2)	Details
dynein (protein family or complex)	2(0,0,0,2)	Details
Tat protein	2(0,0,0,2)	Details
chemokine	2(0,0,0,2)	Details
gamma glutamylcysteine synthetase	2(0,0,0,2)	Details
Kir6.1	2(0,0,0,2)	Details
serine protease inhibitors	2(0,0,0,2)	Details
sodium channel (protein family or complex)	2(0,0,0,2)	Details
arginase	2(0,0,0,2)	Details
granzyme A	2(0,0,0,2)	Details
glucokinase	2(0,0,0,2)	Details
histidine decarboxylase	2(0,0,0,2)	Details
CF 1 (protein family or complex)	2(0,0,0,2)	Details
CYP2D6	2(0,0,0,2)	Details
CYP1A1	2(0,0,0,2)	Details
interferon (protein family or complex)	2(0,0,0,2)	Details
interleukin 2	2(0,0,0,2)	Details
PEPCK	2(0,0,0,2)	Details
CD4	2(0,0,0,2)	Details
p65	2(0,0,0,2)	Details
mcl 1	2(0,0,0,2)	Details
mu opioid receptors	2(0,0,0,2)	Details
Ca v	2(0,0,0,2)	Details
TASK	2(0,0,0,2)	Details
semicarbazide sensitive amine oxidase	2(0,0,0,2)	Details
P67	2(0,0,0,2)	Details
caspase 1	2(0,0,0,2)	Details
plasminogen activator inhibitor	2(0,0,0,2)	Details
cytochrome c oxidase is	2(0,0,0,2)	Details
12 lipoxygenase	2(0,0,0,2)	Details
IFITM3	2(0,0,0,2)	Details
citrate lyase (protein family or complex)	2(0,0,0,2)	Details
keratin 10	2(0,0,0,2)	Details
nuclear pore complex protein Nup98	2(0,0,0,2)	Details
Nicotinamide adenine dinucleotide phosphate oxidase	2(0,0,0,2)	Details
ABCA1	2(0,0,0,2)	Details
Methionine sulfoxide reductase A	2(0,0,0,2)	Details
myelin proteolipid protein	2(0,0,0,2)	Details
RyR 2	2(0,0,0,2)	Details
TGFalpha	2(0,0,0,2)	Details
AARE	2(0,0,0,2)	Details
NDUFA6	2(0,0,0,2)	Details
matrix metalloprotease 2	2(0,0,0,2)	Details
MX2	2(0,0,0,2)	Details
carnitine palmitoyltransferase II	2(0,0,0,2)	Details
glutamic acid decarboxylase	2(0,0,0,2)	Details
tyrosine kinase receptor	2(0,0,0,2)	Details
HSPA8	2(0,0,0,2)	Details
IL 3	2(0,0,0,2)	Details
mineralocorticoid receptor	2(0,0,0,2)	Details
cytosolic phospholipase A2	2(0,0,0,2)	Details
pyrroline 5 carboxylate reductase (protein family or complex)	2(0,0,0,2)	Details
TNFR1	2(0,0,0,2)	Details
tripeptidyl peptidase II	2(0,0,0,2)	Details
P2X3	2(0,0,0,2)	Details
CAT1	2(0,0,0,2)	Details
proline dehydrogenase	2(0,0,0,2)	Details
E3 ubiquitin protein ligase (protein family or complex)	2(0,0,0,2)	Details
glycerophosphate dehydrogenase	2(0,0,0,2)	Details
L pipecolic acid oxidase	2(0,0,0,2)	Details
24 kDa protein	2(0,0,0,2)	Details
galactosyltransferase (protein family or complex)	2(0,0,0,2)	Details
PARK 3	2(0,0,0,2)	Details
NDUFS3	2(0,0,0,2)	Details
squalene epoxidase	2(0,0,0,2)	Details
Glutathione S transferase pi	2(0,0,0,2)	Details
factor A	2(0,0,0,2)	Details
tumor necrosis factor receptors (protein family or complex)	2(0,0,0,2)	Details
P2X receptor (protein family or complex)	2(0,0,0,2)	Details
novel protein	2(0,0,0,2)	Details
Smad 2	2(0,0,0,2)	Details
p42 MAPK	2(0,0,0,2)	Details
death inducing protein	2(0,0,0,2)	Details
lymphocyte protease	2(0,0,0,2)	Details
nucleophosmin	2(0,0,0,2)	Details
transferrin receptor	2(0,0,0,2)	Details
multidrug resistance associated protein 1	2(0,0,0,2)	Details
mM 1	2(0,0,0,2)	Details
HO 2	2(0,0,0,2)	Details
smooth muscle actin	2(0,0,0,2)	Details
heat shock protein 60	2(0,0,0,2)	Details
p42	2(0,0,0,2)	Details
protein phosphatases	2(0,0,0,2)	Details
NRF2	2(0,0,0,2)	Details
nestin	2(0,0,0,2)	Details
Eg5	2(0,0,0,2)	Details
TGFbeta	2(0,0,0,2)	Details
P selectin	2(0,0,0,2)	Details
cyclin E	2(0,0,0,2)	Details
S protein	2(0,0,0,2)	Details
C10	2(0,0,0,2)	Details
yl 1	2(0,0,0,2)	Details
carnitine palmitoyltransferase I	1(0,0,0,1)	Details
phagocyte NADPH oxidase	1(0,0,0,1)	Details
TIM23	1(0,0,0,1)	Details
aquaporin 8	1(0,0,0,1)	Details
beta arrestin 2	1(0,0,0,1)	Details
ESSS	1(0,0,0,1)	Details
nicotinamide mononucleotide adenylyltransferase 1	1(0,0,0,1)	Details
SERCA 1	1(0,0,0,1)	Details
IkappaBbeta	1(0,0,0,1)	Details
4 aminobutyrate aminotransferase	1(0,0,0,1)	Details
T3 receptors	1(0,0,0,1)	Details
docking proteins	1(0,0,0,1)	Details
PDHA	1(0,0,0,1)	Details
tryptophan pyrrolase	1(0,0,0,1)	Details
complex I 51 kDa	1(0,0,0,1)	Details
PRC1	1(0,0,0,1)	Details
thioredoxin reductase 1	1(0,0,0,1)	Details
FMN 1	1(0,0,0,1)	Details
protein Drp1	1(0,0,0,1)	Details
TIM44	1(0,0,0,1)	Details
mitofusin 2	1(0,0,0,1)	Details
NADPH oxidase 1	1(0,0,0,1)	Details
E1B	1(0,0,0,1)	Details
MLC2a	1(0,0,0,1)	Details
mitochondrial transcription termination factor	1(0,0,0,1)	Details
glutamylcysteine synthetase (protein family or complex)	1(0,0,0,1)	Details
Macrophage inflammatory protein 2	1(0,0,0,1)	Details
lipid binding protein	1(0,0,0,1)	Details
MEKK1	1(0,0,0,1)	Details
SP B	1(0,0,0,1)	Details
LRRK1	1(0,0,0,1)	Details
sodium calcium exchanger	1(0,0,0,1)	Details
flavokinase	1(0,0,0,1)	Details
nuclear respiratory factor 1	1(0,0,0,1)	Details
pyruvate dehydrogenase phosphatase	1(0,0,0,1)	Details
pig a	1(0,0,0,1)	Details
selenoprotein H	1(0,0,0,1)	Details
DP 1	1(0,0,0,1)	Details
HSP40	1(0,0,0,1)	Details
PPAR gamma coactivator 1beta	1(0,0,0,1)	Details
lipoxygenase 15	1(0,0,0,1)	Details
Uch L1	1(0,0,0,1)	Details
phosphatidylglycerophosphate synthase	1(0,0,0,1)	Details
3 hydroxybutyrate dehydrogenase	1(0,0,0,1)	Details
complement factor H	1(0,0,0,1)	Details
Tie 1	1(0,0,0,1)	Details
TSC2	1(0,0,0,1)	Details
IDH3A	1(0,0,0,1)	Details
TIM17	1(0,0,0,1)	Details
chaperonins (protein family or complex)	1(0,0,0,1)	Details
CDK5	1(0,0,0,1)	Details
propionyl CoA carboxylase (protein family or complex)	1(0,0,0,1)	Details
IRF1	1(0,0,0,1)	Details
receptor interacting protein	1(0,0,0,1)	Details
B16.6	1(0,0,0,1)	Details
IPF1	1(0,0,0,1)	Details
DTEF 1	1(0,0,0,1)	Details
p65 proteins	1(0,0,0,1)	Details
TFB1M	1(0,0,0,1)	Details
AOX2	1(0,0,0,1)	Details
DRY6	1(0,0,0,1)	Details
transferrin receptor 2	1(0,0,0,1)	Details
6 phosphogluconate dehydrogenase	1(0,0,0,1)	Details
ferritin light chain	1(0,0,0,1)	Details
TIM13	1(0,0,0,1)	Details
cyclophilin A	1(0,0,0,1)	Details
per 4	1(0,0,0,1)	Details
ribosomal protein S6 kinase	1(0,0,0,1)	Details
glycolate oxidase	1(0,0,0,1)	Details
HSP105	1(0,0,0,1)	Details
steroid receptor coactivator	1(0,0,0,1)	Details
Ecto ATPases	1(0,0,0,1)	Details
Mnk 1	1(0,0,0,1)	Details
Les	1(0,0,0,1)	Details
MPP 1	1(0,0,0,1)	Details
endothelial cell adhesion molecules	1(0,0,0,1)	Details
CAT3	1(0,0,0,1)	Details
pleckstrin	1(0,0,0,1)	Details
osteoprotegerin	1(0,0,0,1)	Details
TIM50	1(0,0,0,1)	Details
vanilloid receptor 1	1(0,0,0,1)	Details
pVHL	1(0,0,0,1)	Details
parkin coregulated gene	1(0,0,0,1)	Details
heat shock transcription factor (protein family or complex)	1(0,0,0,1)	Details
glycerol kinase	1(0,0,0,1)	Details
palmitoyl CoA oxidase	1(0,0,0,1)	Details
D amino acid oxidase	1(0,0,0,1)	Details
Kis	1(0,0,0,1)	Details
DIABLO	1(0,0,0,1)	Details
asparagine synthetase	1(0,0,0,1)	Details
purine nucleoside phosphorylase	1(0,0,0,1)	Details
PPARbeta	1(0,0,0,1)	Details
4E BP1	1(0,0,0,1)	Details
succinate semialdehyde dehydrogenase	1(0,0,0,1)	Details
m calpain	1(0,0,0,1)	Details
P46	1(0,0,0,1)	Details
Urokinase type plasminogen activator	1(0,0,0,1)	Details
CC1	1(0,0,0,1)	Details
C17	1(0,0,0,1)	Details
ET B	1(0,0,0,1)	Details
receptor activator of nuclear factor kappaB	1(0,0,0,1)	Details
CD80	1(0,0,0,1)	Details
ubiquitin conjugating enzyme E2	1(0,0,0,1)	Details
TFB2M	1(0,0,0,1)	Details
Adenosine A2A receptor	1(0,0,0,1)	Details
optic atrophy 1	1(0,0,0,1)	Details
intrinsic factors	1(0,0,0,1)	Details
OGG1	1(0,0,0,1)	Details
phospholipase C gamma 1	1(0,0,0,1)	Details
Paf 1	1(0,0,0,1)	Details
PDHB	1(0,0,0,1)	Details
neurofibromin	1(0,0,0,1)	Details
SNAP 1	1(0,0,0,1)	Details
CTGF	1(0,0,0,1)	Details
ubiquitin activating enzyme E1	1(0,0,0,1)	Details
F1FO ATPase	1(0,0,0,1)	Details
Int 7	1(0,0,0,1)	Details
MARCKS	1(0,0,0,1)	Details
Stimulator of Fe Transport	1(0,0,0,1)	Details
acyl CoA synthetase (protein family or complex)	1(0,0,0,1)	Details
surfactant protein	1(0,0,0,1)	Details
SDHD	1(0,0,0,1)	Details
adenylosuccinate synthase	1(0,0,0,1)	Details
ribosomal protein (protein family or complex)	1(0,0,0,1)	Details
LAT2	1(0,0,0,1)	Details
matrix metalloproteinase 9	1(0,0,0,1)	Details
alpha 2 macroglobulin	1(0,0,0,1)	Details
CD28	1(0,0,0,1)	Details
costimulatory molecules	1(0,0,0,1)	Details
adrenomedullin	1(0,0,0,1)	Details
Toll like receptor 4	1(0,0,0,1)	Details
CDK4	1(0,0,0,1)	Details
ferredoxin reductase	1(0,0,0,1)	Details
terminal deoxynucleotidyltransferase	1(0,0,0,1)	Details
TRPM2	1(0,0,0,1)	Details
SK2	1(0,0,0,1)	Details
C21	1(0,0,0,1)	Details
cis 3	1(0,0,0,1)	Details
sialyltransferase	1(0,0,0,1)	Details
adrenodoxin	1(0,0,0,1)	Details
flavin reductase	1(0,0,0,1)	Details
rhodopsin	1(0,0,0,1)	Details
heat shock protein 72	1(0,0,0,1)	Details
organic anion transporter	1(0,0,0,1)	Details
von Willebrand factor	1(0,0,0,1)	Details
E selectin	1(0,0,0,1)	Details
Vinculin	1(0,0,0,1)	Details
GATA 4	1(0,0,0,1)	Details
CD31	1(0,0,0,1)	Details
Nkx2.5	1(0,0,0,1)	Details
neuron specific enolase	1(0,0,0,1)	Details
versican	1(0,0,0,1)	Details
myosins (protein family or complex)	1(0,0,0,1)	Details
activating transcription factor 2	1(0,0,0,1)	Details
CD16	1(0,0,0,1)	Details
Smad (protein family or complex)	1(0,0,0,1)	Details
RANTES	1(0,0,0,1)	Details
B12	1(0,0,0,1)	Details
rac 1	1(0,0,0,1)	Details
cyclin dependent kinase 2	1(0,0,0,1)	Details
P22	1(0,0,0,1)	Details
Protein S	1(0,0,0,1)	Details
Sulfite Oxidase	1(0,0,0,1)	Details
cytoplasmic protein	1(0,0,0,1)	Details
ISCU	1(0,0,0,1)	Details
SP2	1(0,0,0,1)	Details
CD86	1(0,0,0,1)	Details
Neuraminidase	1(0,0,0,1)	Details
apolipoprotein	1(0,0,0,1)	Details
CD34	1(0,0,0,1)	Details
sphingomyelinase	1(0,0,0,1)	Details
FRDA	1(0,0,0,1)	Details
thyroid stimulating hormone (protein family or complex)	1(0,0,0,1)	Details
IL 1 alpha	1(0,0,0,1)	Details
cytochrome P 450 reductase	1(0,0,0,1)	Details
alpha interferon	1(0,0,0,1)	Details
ribonucleotide reductase (protein family or complex)	1(0,0,0,1)	Details
A10	1(0,0,0,1)	Details
phosphoglycerate kinase	1(0,0,0,1)	Details
NR1	1(0,0,0,1)	Details
serine threonine protein kinases	1(0,0,0,1)	Details
Red 2	1(0,0,0,1)	Details
K12	1(0,0,0,1)	Details
stem cell factor	1(0,0,0,1)	Details
d x	1(0,0,0,1)	Details
C15	1(0,0,0,1)	Details
NR2B	1(0,0,0,1)	Details
Tyrosinase	1(0,0,0,1)	Details
epoxide hydrolase	1(0,0,0,1)	Details
interleukin 4	1(0,0,0,1)	Details
casein	1(0,0,0,1)	Details
P27	1(0,0,0,1)	Details
SUR2	1(0,0,0,1)	Details
G protein	1(0,0,0,1)	Details
SK3	1(0,0,0,1)	Details
adenosine kinase	1(0,0,0,1)	Details
PP2	1(0,0,0,1)	Details
myeloperoxidase	1(0,0,0,1)	Details
galanin	1(0,0,0,1)	Details
p70	1(0,0,0,1)	Details
P12	1(0,0,0,1)	Details
sulfotransferase	1(0,0,0,1)	Details
extracellular superoxide dismutase	1(0,0,0,1)	Details
GT1	1(0,0,0,1)	Details
5 lipoxygenase	1(0,0,0,1)	Details
catechol O methyltransferase	1(0,0,0,1)	Details
glycine receptor (protein family or complex)	0(0,0,0,0)	Details
lag 3	0(0,0,0,0)	Details
myelin basic protein	0(0,0,0,0)	Details
glutamine synthetase	0(0,0,0,0)	Details
parvalbumin	0(0,0,0,0)	Details
AT1	0(0,0,0,0)	Details
monoamine oxidase A	0(0,0,0,0)	Details
granulocyte macrophage colony stimulating factor	0(0,0,0,0)	Details
protein disulfide isomerase	0(0,0,0,0)	Details
progesterone receptor	0(0,0,0,0)	Details
cyclic nucleotide phosphodiesterase	0(0,0,0,0)	Details
thymidine kinase	0(0,0,0,0)	Details
myosin light chain kinase	0(0,0,0,0)	Details
OCTN2	0(0,0,0,0)	Details
histatin 5	0(0,0,0,0)	Details
NKCC1	0(0,0,0,0)	Details
organic anion transporters	0(0,0,0,0)	Details
cell cycle regulatory proteins	0(0,0,0,0)	Details
Fas Ligand	0(0,0,0,0)	Details
serine threonine protein phosphatases	0(0,0,0,0)	Details
CD45	0(0,0,0,0)	Details
PKCalpha	0(0,0,0,0)	Details
cytoglobin	0(0,0,0,0)	Details
cyclin D3	0(0,0,0,0)	Details
mitochondrial dicarboxylate carrier	0(0,0,0,0)	Details
glutamate transporter 1	0(0,0,0,0)	Details
nor 1	0(0,0,0,0)	Details
Hb 5	0(0,0,0,0)	Details
phytanic acid oxidase	0(0,0,0,0)	Details
myosin phosphatase (protein family or complex)	0(0,0,0,0)	Details
apyrase	0(0,0,0,0)	Details
trap alpha	0(0,0,0,0)	Details
lymphotoxin	0(0,0,0,0)	Details
calcium dependent phospholipase A2	0(0,0,0,0)	Details
OCT2	0(0,0,0,0)	Details
photoparoxysmal response	0(0,0,0,0)	Details
LMP7	0(0,0,0,0)	Details
argininosuccinate synthase	0(0,0,0,0)	Details
phospholipid transfer protein	0(0,0,0,0)	Details
cdc25a	0(0,0,0,0)	Details
neuroglobin	0(0,0,0,0)	Details
SK1	0(0,0,0,0)	Details
Mitofusin 1	0(0,0,0,0)	Details
MT1A	0(0,0,0,0)	Details
ERK5	0(0,0,0,0)	Details
mitogen activated protein kinase 10	0(0,0,0,0)	Details
OCT1	0(0,0,0,0)	Details
PLA2	0(0,0,0,0)	Details

Docunmentation of Network Visuallization