Protein Information

Name glucose 6 phosphatase
Synonyms G 6 Pase; G6PC; G6PT; G6Pase; GSD1a; Glucose 6 phosphatase; Glucose 6 phosphatase hydrolytic subunit; G6Pases…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
19664596 Ota S, Horigome K, Ishii T, Nakai M, Hayashi K, Kawamura T, Kishino A, Taiji M, Kimura T: Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism. Biochem Biophys Res Commun. 2009 Oct 16;388(2):311-6. Epub 2009 Aug 5.

Both metformin and rotenone, an inhibitor of respiratory chain complex I, suppressed glucose-6-phosphatase (G6pc), a rate limiting enzyme of liver glucose production, mRNA expression in a rat hepatoma cell line accompanied by a reduction of intracellular ATP concentration and an activation of AMP-activated protein kinase (AMPK).
2(0,0,0,2) Details
1347181 Hirai K, Ikeda K, Wang GY: Paraquat damage of rat liver mitochondria by superoxide production depends on extramitochondrial NADH. Toxicology. 1992;72(1):1-16.

Pure rat liver heavy mitochondrial fractions, in which the absence of significant microsomal contamination was confirmed by electron microscopy and by the lack of glucose-6-phosphatase activity, were used to demonstrate the effect of paraquat on mitochondrial ultrastructure in the presence of external NADH.
These alterations were resistant to rotenone and malate plus glutamate or NADPH could not substitute for NADH.
1(0,0,0,1) Details
2544141 Alderson BH, Volpe P: Distribution of endoplasmic reticulum and calciosome markers in membrane fractions isolated from different regions of the canine brain. Arch Biochem Biophys. 1989 Jul;272(1):162-74.

Markers of endoplasmic reticulum (glucose-6-phosphate phosphatase and rotenone-insensitive NADPH cytochrome c reductase) and markers of the 1,4,5-trisphosphate (IP3)-sensitive Ca2+ store ([3H] IP3 binding and IP3-induced Ca2+ release) were measured.
31(0,1,1,1) Details
2996532 Niranjan BG, Avadhani NG, DiGiovanni J: Formation of benzo (alpha) pyrene metabolites and DNA adducts catalyzed by a rat liver mitochondrial monooxygenase system. Biochem Biophys Res Commun. 1985 Sep 16;131(2):935-42.

The mitoplasts used in this study contained less than 1% microsomal marker enzymes: rotenone insensitive NADPH cytochrome c reductase and glucose-6-phosphatase.
6(0,0,1,1) Details
4309122 Shephard EH, Hubscher G: Phosphatidate biosynthesis in mitochondrial subfractions of rat liver. . Biochem J. 1969 Jun;113(2):429-40.

Phosphatidate formation was measured in all subcellular fractions and subfractions and was compared with the distribution of succinate dehydrogenase, monoamine oxidase, rotenone-insensitive NADH cytochrome c reductase, arylsulphatase, urate oxidase, arylesterase and glucose 6-phosphatase. 3.
6(0,0,1,1) Details
224923 Bers DM: Isolation and characterization of cardiac sarcolemma. Biochim Biophys Acta. 1979 Jul 19;555(1):131-46.

There was very little contamination of the sarcolemmal fraction by sarcoplasmic reticulum (as judged by Ca2+-ATPase and glucose-6-phosphatase activities) or inner mitochondrial membranes (as judged by succinate dehydrogenase activity).
There may, however, be some contamination by outer mitochondrial membranes (as judged by monoamine oxidase and rotenone-insensitive NADH cytochrome c reductase activities) which have rarely been monitored in cardiac sarcolemmal preparations.
1(0,0,0,1) Details