Protein Information

Name phosphoenolpyruvate carboxykinase
Synonyms PCK 1; PCK1; PEP carboxykinase; PEPCK cytosolic; PEPCK 1; PEPCK C; PEPCKC…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
6088521 Erecinska M, Wilson DF: Relationship of the intra- and extramitochondrial adenine nucleotide ratios during synthesis of phosphoenolpyruvate using extramitochondrial ATP. J Biol Chem. 1984 Sep 10;259(17):10904-6.

Mitochondria prepared from the livers of guinea pig, chicken, and pigeon all actively synthesize phosphoenolpyruvate from oxalacetate and GTP, utilizing phosphoenolpyruvate carboxykinase.
In this study, synthesis of phosphoenolpyruvate by guinea pig liver mitochondria was studied under conditions for which the only source of GTP was extramitochondrial ATP via adenine nucleotide translocase and nucleoside diphosphate kinase (the mitochondria were treated with rotenone, oligomycin, uncoupler, and fluorocitrate).
4(0,0,0,4) Details
10844979 Obungu VH, Kiaira JK, Olembo NK, Njogu MR: Pathways of glucose catabolism in procyclic Trypanosoma congolense. Indian J Biochem Biophys. 1999 Oct;36(5):305-11.

Studies of respiration on glucose in procyclic Trypanosoma congolense in the presence of rotenone, antimycin, cyanide, salicylhydroxamic acid and malonate have indicated the presence of NADH dehydrogenase, cytochrome b-c1, cytochrome aa3, trypanosome alternate oxidase and NADH fumarate reductase/succinate dehydrogenase pathway that contributes electrons to coenzyme Q of the respiratory chain.
Phosphoenolpyruvate carboxykinase, pyruvate dehydrogenase, succinate dehydrogenase, NADP (+)-linked malic enzyme, NADH fumarate reductase, malate dehydrogenase, and alpha-ketoglutarate dehydrogenase and glycerol kinase on the other hand had specific activities greater than 60 nanomoles/min/mg protein.
1(0,0,0,1) Details
18403382 Hong HT, Nose A, Agarie S, Yoshida T: Malate metabolism in Hoya carnosa mitochondria and its role in photosynthesis during CAM phase III. J Exp Bot. 2008;59(7):1819-27. Epub 2008 Apr 9.


This study investigated the respiratory properties and the role of the mitochondria isolated from one phosphoenolpyruvate carboxykinase (PCK)-CAM plant, Hoya carnosa, in malate metabolism during CAM phase III.
1(0,0,0,1) Details
14607783 Peterside IE, Selak MA, Simmons RA: Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats. Am J Physiol Endocrinol Metab. 2003 Dec;285(6):E1258-66.

Phosphoenolpyruvate carboxykinase (PEPCK) expression was also measured in livers of IUGR and control offspring.
Rotenone-sensitive NADH-O2 oxidoreductase activity was similar in control and IUGR mitochondria at all ages, showing that the defect responsible for decreased pyruvate, glutamate, and alpha-ketoglutarate oxidation in IUGR liver precedes the electron transport chain and involves pyruvate and alpha-ketoglutarate dehydrogenases.
1(0,0,0,1) Details