| Name | metallothionein (protein family or complex) |
|---|---|
| Synonyms | Metallothionein; Metallothioneins |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12880480 | Sharma SK, Ebadi M: Metallothionein attenuates 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in dopaminergic neurons. Antioxid Redox Signal. 2003 Jun;5(3):251-64. Pretreatment with selegiline or metallothionein suppressed 1-methyl-4-phenylpyridinium ion-, -, and rotenone-induced increases in mitochondrial accumulation. |
89(1,1,1,9) | Details |
| 16402917 | Reinecke F, Levanets O, Olivier Y, Louw R, Semete B, Grobler A, Hidalgo J, Smeitink J, Olckers A, Van der Westhuizen FH: Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-treated HeLa cells. Biochem J. 2006 Apr 15;395(2):405-15. |
87(1,1,2,2) | Details |
| 16750479 | Sharma SK, El Refaey H, Ebadi M: Complex-1 activity and 18F- uptake in genetically engineered mouse model of Parkinson's disease and the neuroprotective role of Brain Res Bull. 2006 Jun 15;70(1):22-32. Epub 2005 Dec 27. Regional distribution of and mitochondrial complex-1 activity were estimated in the brains of control-(C57BL/6), metallothionein knock out-, metallothionein transgenic-, and homozygous weaver mutant mice; and human dopaminergic (SK-N-SH) cells with a primary objective to determine the neuroprotective potential of in Parkinson's disease. Direct exposure of rotenone also reduced coenzyme Q10, complex-1 activity, and mitochondrial membrane potential in SK-N-SH cells. |
3(0,0,0,3) | Details |
| 19818760 | Kadota Y, Suzuki S, Ideta S, Fukinbara Y, Kawakami T, Imai H, Nakagawa Y, Sato M: Enhanced metallothionein gene expression induced by mitochondrial oxidative stress is reduced in phospholipid hydroperoxide peroxidase-overexpressed cells. Eur J Pharmacol. 2010 Jan 25;626(2-3):166-70. Epub 2009 Oct 8. The enhanced expression of metallothionein-I and metallothionein-II mRNA in rotenone-treated control cells was significantly decreased in rotenone-treated PHGPx-ov cells, suggesting that the peroxide that is formed by anions generated in mitochondria diffuse into the cytosol and induce metallothionein mRNA expression. |
10(0,0,1,5) | Details |