| Name | caspase 1 |
|---|---|
| Synonyms | CASP 1; p45; CASP1; CASP1 nirs variant 1; CASP1 protein; Caspase 1; Caspase 1 isoform alpha variant; Caspase 1 isoform zeta… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9751160 | Sengpiel B, Preis E, Krieglstein J, Prehn JH: -induced production and neurotoxicity in cultured rat hippocampal neurons: role of mitochondria. Eur J Neurosci. 1998 May;10(5):1903-10. Brief exposure to the selective agonist 100-300 microM, 10 min) induced significant neuronal death, which was sensitive to cycloheximide (1 microM) and the caspase-1 inhibitor, acetyl-Tyr-Val--Asp-chloromethylketone (10 microM). Both -induced production and neurotoxicity were reduced by inhibition of mitochondrial electron transport using either (1 mM), or a combination of rotenone (2 microM) and oligomycin (2 microM). |
1(0,0,0,1) | Details |
| 8657188 | Wachsman JT: The beneficial effects of dietary restriction: reduced oxidative damage and enhanced apoptosis. Mutat Res. 1996 Feb 19;350(1):25-34. The role of poly (ADP- in apoptosis, carcinogenesis, and aging could be studied by the use of modulators of PARP activity (3-aminobenzamide, 3-nitrosobenzamide, 1% etc.), inhibitors of poly ADP- glycohydrolase activity (ethacridine, 43 degrees C, etc.), and inhibitors of the PARP-specific protease (interleukin-1 beta converting enzyme (ICE)-like protease). It is proposed that inhibitors of mitochondrial electron transport and/or uncouplers of oxidative phosphorylation (rotenone, amytal, amiodarone, valinomycin, etc.), when used at extremely low doses, could mimic the effects of CR in model systems. |
1(0,0,0,1) | Details |
| 10987825 | Bal-Price A, Brown GC: -induced necrosis and apoptosis in PC12 cells mediated by mitochondria. J Neurochem. 2000 Oct;75(4):1455-64. A 24-h incubation of PC12 cells with NO donors (SNAP or NOC-18) or specific inhibitors of mitochondrial respiration (myxothiazol, rotenone, or azide), in the absence of caused total ATP depletion and resulted in 80-100% necrosis. |
0(0,0,0,0) | Details |
| 10549166 | Khar A, Ali AM, Begum Z, Pardhasaradhi BV, Varalakshmi C: Induction of apoptosis in AK-5 cells by rotenone involves participation of caspases. Indian J Biochem Biophys. 1999 Apr;36(2):77-81. |
0(0,0,0,0) | Details |
| 12551850 | Pei W, Liou AK, Chen J: Two caspase-mediated apoptotic pathways induced by rotenone toxicity in cortical neuronal cells. FASEB J. 2003 Mar;17(3):520-2. Epub 2003 Jan 22. |
0(0,0,0,0) | Details |