| Name | fibronectin |
|---|---|
| Synonyms | CIG; MSF; Cold insoluble globulin; FINC; FN; FN1; Fibronectin; Fibronectin 1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17395008 | Del Carlo M, Schwartz D, Erickson EA, Loeser RF: Endogenous production of reactive species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments. Free Radic Biol Med. 2007 May 1;42(9):1350-8. Epub 2007 Jan 24. Preincubation of chondrocytes with rotenone, an inhibitor of the mitochondrial electron transport chain, or nordihydroguaiaretic acid (NDGA), a selective 5-lipoxygenase inhibitor, partially prevented FN-f-stimulated MMP-13 production and decreased MAP kinase and NF-kappaB phosphorylation. |
3(0,0,0,3) | Details |
| 15086456 | Lee HB, Yu MR, Song JS, Ha H: Reactive species amplify protein kinase C signaling in high -induced fibronectin expression by human peritoneal mesothelial cells. Kidney Int. 2004 Apr;65(4):1170-9. oxidase inhibitors (diphenyleneiodinium and apocynin) and an inhibitor of mitochondrial electron transport chain subunit I (rotenone) all effectively inhibited high -induced cellular ROS generation and fibronectin secretion. |
90(1,1,1,10) | Details |
| 17635749 | Ho C, Lee PH, Huang WJ, Hsu YC, Lin CL, Wang JY: -induced fibronectin gene expression through Ras-mediated oxidase activation in renal mesangial cells. Nephrology. 2007 Aug;12(4):348-56. METHODS: Rat kidney mesangial cells with or without pretreatment with inhibitors, including superoxide dismutase, catalase, L-NAME, diphenylene iodonium, rotenone, allopurinol, PD98059, SB203580 and SP600125 were cultured in medium containing 100 microM MGO. |
6(0,0,0,6) | Details |
| 16572112 | Lin CL, Wang FS, Kuo YR, Huang YT, Huang HC, Sun YC, Kuo YH: Ras modulation of activates ERK-dependent fibronectin expression in diabetes-induced renal injuries. Kidney Int. 2006 May;69(9):1593-600. Pretreatment with diphenyliodonium, not allopurinol or rotenone, reduced high- and AGE augmentation of synthesis and fibronection expression. |
4(0,0,0,4) | Details |
| 15677311 | Rhyu DY, Yang Y, Ha H, Lee GT, Song JS, Uh ST, Lee HB: Role of reactive species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. J Am Soc Nephrol. 2005 Mar;16(3):667-75. Epub 2005 Jan 26. Growth-arrested and synchronized NRK-52E cells were stimulated with TGF-beta1 (0.2 to 20 ng/ml) or H (2) O (2) (1 to 500 microM) in the presence or absence of antioxidants or catalase), inhibitors of oxidase (diphenyleneiodonium and apocynin), mitochondrial electron transfer chain subunit I (rotenone), and MAPK (PD 98059, an MEK [MAP kinase/ERK kinase] inhibitor, or p38 MAPK inhibitor) for up to 96 h. TGF-beta1 increased dichlorofluorescein-sensitive cellular ROS, phosphorylated Smad 2, p38 MAPK, extracellular signal-regulated kinases (ERK) 1/2, alpha-smooth muscle actin (alpha-SMA) expression, and fibronectin secretion and decreased E-cadherin expression. |
1(0,0,0,1) | Details |
| 17651460 | Prigione A, Cortopassi G: Mitochondrial DNA deletions induce the -activated protein kinase energy stress pathway and result in decreased secretion of some proteins. Aging Cell. 2007 Oct;6(5):619-30. Epub 2007 Jul 26. AMPK induction is known to decrease secretory processes in some cells, and the secretion of both osteoprotegerin (OPG) and fibronectin (FN) proteins to the extracellular space was significantly deficient. The defects in ATP synthesis, induction of the AMPK and SREBF1 transcripts, and decreased expression of ARL2 and secretion of OPG and FN were recapitulated by low doses of rotenone, demonstrating that they were a specific consequence of electron transport chain inhibition. |
1(0,0,0,1) | Details |