Name | calnexin |
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Synonyms | CANX; p90; CLX; CNX; Calnexin; Calnexin precursor; IP90; Major histocompatibility complex Class I antigen binding protein p88… |
Name | rotenone |
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CAS |
PubMed | Abstract | RScore(About this table) | |
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16774923 | Ogburn KD, Figueiredo-Pereira ME: Cytoskeleton/endoplasmic reticulum collapse induced by parallels centrosomal deposition of ubiquitinated protein aggregates. J Biol Chem. 2006 Aug 11;281(32):23274-84. Epub 2006 Jun 14. This aberrant protein deposition, triggered by a product of inflammation, may be common to other compounds that disrupt microtubules and induce protein aggregation, such as MPP+ and rotenone, found to be associated with neurodegeneration. This cyclopentenone prostaglandin triggered endoplasmic reticulum (ER) collapse and the redistribution of ER proteins, such as calnexin and catechol-O-methyltransferase, into a large centrosomal aggregate containing ubiquitinated proteins and alpha-synuclein. |
1(0,0,0,1) | Details |
18801963 | Garciarena CD, Caldiz CI, Correa MV, Schinella GR, Mosca SM, Chiappe de Cingolani GE, Cingolani HE, Ennis IL: Na+/H+ exchanger-1 inhibitors decrease myocardial production via direct mitochondrial action. J Appl Physiol. 2008 Dec;105(6):1706-13. Epub 2008 Sep 18. The mitochondria appeared to be the source of the NOX-dependent ROS released by the "ROS-induced ROS release mechanism" that was blunted by the mitochondrial ATP-sensitive potassium channel blockers 5-hydroxydecanoate and glibenclamide, inhibition of complex I of the electron transport chain with rotenone, and inhibition of the permeability transition pore (MPTP) by cyclosporin A. Increased O (2)(-) production, as expected, stimulated ERK1/2 and p90 ribosomal S6 kinase phosphorylation. |
1(0,0,0,1) | Details |
16854843 | Jin J, Li GJ, Davis J, Zhu D, Wang Y, Pan C, Zhang J: Identification of novel proteins associated with both alpha-synuclein and DJ-1. Mol Cell Proteomics. 2007 May;6(5):845-59. Epub 2006 Jul 18. In the current study, we analyzed proteins associated with alpha-synuclein and/or DJ-1 with a robust proteomics technique called stable isotope labeling by amino acids in cell culture (SILAC) in dopaminergic MES cells exposed to rotenone versus controls. A subset of these proteins (mortalin, nucleolin, grp94, calnexin, and clathrin) was further validated for their association with both alpha-synuclein and DJ-1 using confocal microscopy, Western blot, and/or immunoprecipitation. |
1(0,0,0,1) | Details |