| Name | E3 ubiquitin protein ligase (protein family or complex) |
|---|---|
| Synonyms | E3 ubiquitin protein ligase; E3 ubiquitin protein ligases |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18586549 | Koch A, Lehmann-Horn K, Dachsel JC, Gasser T, Kahle PJ, Lucking CB: Proteasomal inhibition reduces parkin mRNA in PC12 and SH-SY5Y cells. Parkinsonism Relat Disord. 2009 Mar;15(3):220-5. Epub 2008 Jun 30. Mutations in the gene encoding the E3 ubiquitin-protein ligase parkin have been shown to be a common genetic cause of familial early-onset Parkinson's disease (PD). We systematically investigated whether PD-related stresses including MG132 and epoxomicin (proteasomal impairment), tunicamycin (unfolded protein stress), and rotenone (mitochondrial dysfunction) resulted in expressional changes of parkin and other E3 ubiquitin ligases (dorfin, SIAH-1). |
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| 16375772 | Perez FA, Curtis WR, Palmiter RD: Parkin-deficient mice are not more sensitive to or methamphetamine neurotoxicity. BMC Neurosci. 2005 Dec 24;6:71. Nevertheless, Parkin-deficient mice could be more sensitive to other neurotoxins, such as rotenone or MPTP, which have different mechanisms of action; therefore, identifying conditions that precipitate parkinsonism specifically in Parkin-deficient mice would increase the utility of this model and could provide insight into the mechanism of AR-JP. BACKGROUND: Autosomal recessive juvenile parkinsonism (AR-JP) is caused by mutations in the parkin gene which encodes an E3 ubiquitin-protein ligase. |
1(0,0,0,1) | Details |