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Simoncini S, Sapet C, Camoin-Jau L, Bardin N, Harle JR, Sampol J, Dignat-George F, Anfosso F: Role of reactive oxygen species and p38 MAPK in the induction of the pro-adhesive endothelial state mediated by IgG from patients with anti-phospholipid syndrome. Int Immunol. 2005 Apr;17(4):489-500. Epub 2005 Mar 4.
ROS inhibition observed in the presence of diphenylene iodonium and rotenone indicated an involvement of a membrane-bound oxidase and the mitochondrial transport chain as sources of ROS.
ROS acted as a second messenger by activating the p38 mitogen-activated protein kinase and its subsequent target, the stress-related transcription factor activating transcription factor-2 (ATF-2). |
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