| Name | ADH1 |
|---|---|
| Synonyms | ADH 1; ADH1; ADH1A; Alcohol dehydrogenase 1; Alcohol dehydrogenase 1A; Alcohol dehydrogenase alpha subunit; Alcohol dehydrogenase 1s; Alcohol dehydrogenase 1As… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12604196 | Niknahad H, Shuhendler A, Galati G, Siraki AG, Easson E, Poon R, O'Brien PJ: Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl metabolizing enzymes. Chem Biol Interact. 2003 Feb 1;143-144:119-28. Although was a better substrate than salicylaldehyde for ADH1, cytosolic generators (e.g. xylitol) prevented salicylaldehyde and cytotoxicity similarly. Inhibition of mitochondrial ALDH with chloral hydrate, crotonaldehyde or citral or decreasing mitochondrial NAD+ with rotenone increased induced cytotoxicity with a much smaller effect on salicylaldehyde induced cytotoxicity. |
1(0,0,0,1) | Details |
| 12604195 | Niknahad H, Siraki AG, Shuhendler A, Khan S, Teng S, Galati G, Easson E, Poon R, O'Brien PJ: Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl-metabolizing enzymes. Chem Biol Interact. 2003 Feb 1;143-144:107-17. Although acrolein-induced cytotoxicity was only delayed by antioxidants or glycolytic substrates (e.g. it was prevented by generators (e.g. xylitol and due to increased metabolism by ADH1. Decadienal-induced cytotoxicity was also more increased by mitochondrial ALDH2 inhibitors than acrolein and was more increased by decreasing mitochondrial NAD+ with rotenone or decreased by increasing mitochondrial NAD+ with |
3(0,0,0,3) | Details |