Protein Information

Name choline acetyltransferase
Synonyms CHAT; CHOACTase; CLAT; CMS1A; CMS1A2; ChAT; Choline O acetyltransferase; Choline acetylase…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
17367952 Samantaray S, Knaryan VH, Guyton MK, Matzelle DD, Ray SK, Banik NL: The parkinsonian neurotoxin rotenone activates calpain and caspase-3 leading to motoneuron degeneration in spinal cord of Lewis rats. Neuroscience. 2007 May 11;146(2):741-55. Epub 2007 Mar 23.

The finding of ChAT (+) cell death also suggested degeneration of SC motoneurons in rotenone-induced experimental Parkinsonism.
7(0,0,1,2) Details
14697328 Bonsi P, Calabresi P, De Persis C, Papa M, Centonze D, Bernardi G, Pisani A: Early ionic and membrane potential changes caused by the pesticide rotenone in striatal cholinergic interneurons. Exp Neurol. 2004 Jan;185(1):169-81.

Morphological analysis of the rotenone effects on striatal slices showed a significant decrease in the number of choline acetyltransferase (ChAT) immunoreactive cells.
6(0,0,1,1) Details
14766796 Lapointe N, St-Hilaire M, Martinoli MG, Blanchet J, Gould P, Rouillard C, Cicchetti F: Rotenone induces non-specific central nervous system and systemic toxicity. FASEB J. 2004 Apr;18(6):717-9. Epub 2004 Feb 6.

0(0,0,0,0) Details