Protein Information

Name microtubule associated protein tau
Synonyms DDPAC; FTDP 17; MAPT; MAPTL; MSTD; MTBT 1; MTBT 2; MTBT1…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
16930453 Dickey CA, Ash P, Klosak N, Lee WC, Petrucelli L, Hutton M, Eckman CB: Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Mol Neurodegener. 2006 Jul 26;1:6.

The microtubule-associated protein tau (MAPT) is a pathological component of several neurodegenerative diseases and clinical dementias.
In fact, one of the compounds we identified, rotenone, has been used extensively to model PD in rodents.
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