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Sugeno N, Takeda A, Hasegawa T, Kobayashi M, Kikuchi A, Mori F, Wakabayashi K, Itoyama Y: Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death. J Biol Chem. 2008 Aug 22;283(34):23179-88. Epub 2008 Jun 18.
Following the treatment with rotenone, a mitochondrial complex I inhibitor, wild type alpha-synuclein-overexpressing cells demonstrated intracellular aggregations, which shared a number of features with Lewy bodies, although cells overexpressing the S129A mutant, in which phosphorylation at Ser (129) was blocked, showed few aggregations.
Casein kinase 2 inhibitor, which decreased alpha-synuclein phosphorylation, also reduced UPR activation. |
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