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Gimenez-Cassina A, Lim F, Cerrato T, Palomo GM, Diaz-Nido J: Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3. J Biol Chem. 2009 Jan 30;284(5):3001-11. Epub 2008 Nov 25.
Interfering with either the mitochondrial binding of HKII or HKII expression significantly diminished the neuroprotection evoked by GSK-3 inhibition, and importantly, HKII overexpression is sufficient to protect against rotenone-induced cell death. |
35(0,1,1,5) |
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