Protein Information

Name SK2
Synonyms 3 prime phosphoadenosine 5 prime phosphosulfate synthase 2; SK2; 3' phosphoadenosine 5' phosphosulfate synthase 2; APS kinase 2; ATP sulfurylase/APS kinase 2; ATP sulfurylase/APS kinase isoform SK2; ATP sulfurylase/adenosine 5 prime phosphosulfate kinase; ATPSK 2…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
16173951 Keating DJ, Rychkov GY, Giacomin P, Roberts ML: Oxygen-sensing pathway for SK channels in the ovine adrenal medulla. . Clin Exp Pharmacol Physiol. 2005 Oct;32(10):882-7.

In a heterologous expression system, SK2 and SK3 channels, the channels that initiate hypoxia-evoked changes in AMCC function, are modulated appropriately by changes in cellular redox state.
Different tissues appear to use either NADPH oxidase or a rotenone-sensitive mechanism as an oxygen sensor.
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