Protein Information

Name VPS41
Synonyms HVPS41; HVSP41; S53; VPS41; Vacuolar assembly protein 41; Vacuolar assembly protein VPS41 homolog; Vacuolar protein sorting 41; Vacuolar protein sorting associated protein 41 homolog…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
19850127 Ruan Q, Harrington AJ, Caldwell KA, Caldwell GA, Standaert DG: VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease. Neurobiol Dis. 2010 Feb;37(2):330-8. Epub 2009 Oct 20.

We also observed that hVPS41 reduced the accumulation of insoluble high-molecular weight forms of alpha-syn in SH-SY5Y cells after treatment with rotenone.
43(0,1,2,8) Details
8442768 Anderson WM, Delinck DL, Benninger L, Wood JM, Smiley ST, Chen LB: Cytotoxic effect of thiacarbocyanine dyes on human colon carcinoma cells and inhibition of bovine heart mitochondrial NADH-ubiquinone reductase activity via a rotenone-type mechanism by two of the dyes. Biochem Pharmacol. 1993 Feb 9;45(3):691-6.

Five lipophilic-cationic thiacarbocyanine compounds differing in the side chains (methyl-S13, ethyl-S23, propyl-S33, butyl-S43, and pentyl-S53) and a related thiadicarbocyanine compound with ethyl side chains (S25) exhibited a selective cytotoxic effect on human colon carcinoma cells compared to green monkey kidney epithelial cells.
1(0,0,0,1) Details