Protein Information

Name thioredoxin reductase
Synonyms ACR 1; PLP; ACR1; AOEB166; Alu corepressor 1; Antioxidant enzyme B166; B166; Liver tissue 2D page spot 71B…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
16036347 Rigobello MP, Folda A, Baldoin MC, Scutari G, Bindoli A: Effect of auranofin on the mitochondrial generation of hydrogen peroxide. Free Radic Res. 2005 Jul;39(7):687-95.

Role of thioredoxin reductase..
Auranofin was also able to unmask the production of hydrogen peroxide occurring in the presence of rotenone.
3(0,0,0,3) Details
17229725 Gray JP, Heck DE, Mishin V, Smith PJ, Hong JY, Thiruchelvam M, Cory-Slechta DA, Laskin DL, Laskin JD: Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD (P) H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase. J Biol Chem. 2007 Mar 16;282(11):7939-49. Epub 2007 Jan 17.

The mitochondrial poisons cyanide, rotenone, and antimycin A prevented mitochondrial- but not paraquat-mediated oxygen flux into cells.
3(0,0,0,3) Details