| Name | ET A |
|---|---|
| Synonyms | EDNRA; ET A; ETA; ETA R; ETRA; Endothelin A receptor; Endothelin 1 receptor; Endothelin 1 receptor precursor… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18487445 | Viel EC, Benkirane K, Javeshghani D, Touyz RM, Schiffrin EL: Xanthine oxidase and mitochondria contribute to vascular generation in DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H281-8. Epub 2008 May 16. O (2)(*-) generation decreased with in situ treatment by tenoyltrifluoroacetone and CCCP, inhibitors of mitochondrial electron transport complexes II and IV, respectively, whereas rotenone (mitochondrial complex I inhibitor) had no effect. Systolic blood pressure rose in DOCA-salt rats and was reduced after 3 wk by apocynin [NAD (P) H oxidase inhibitor and/or radical scavenger], allopurinol (XO inhibitor), bosentan (ET (A/B) receptor antagonist), BMS-182874 (BMS; ET (A) receptor antagonist), and hydralazine. |
2(0,0,0,2) | Details |
| 19576886 | Matsuo J, Oku H, Kanbara Y, Kobayashi T, Sugiyama T, Ikeda T: Involvement of oxidase and protein kinase C in endothelin-1-induced production in retinal microvessels. Exp Eye Res. 2009 Nov;89(5):693-9. Epub 2009 Jul 2. The receptor mechanisms were determined by BQ-123 and BQ-788, receptor antagonists for ET (A) and ET (B) receptors, respectively, and also by IRL-1620, a selective agonist for ET (B) receptors. In addition, the changes induced by adding apocynin (10 microM), myr-PKC (1.0 microM), allopurinol (100 microM), rotenone (10 microM), or L-NAME (100 microM) with ET-1 were evaluated. |
2(0,0,0,2) | Details |
| 11728422 | Yuki K, Suzuki T, Katoh S, Kakinuma Y, Miyauchi T, Mitsui Y: Endothelin-1 stimulates cardiomyocyte injury during mitochondrial dysfunction in culture. Eur J Pharmacol. 2001 Nov 16;431(2):163-70. Primary cultured cardiomyocytes from neonatal rats were pretreated with rotenone, a mitochondrial complex I inhibitor, and the cytotoxic effect of endothelin-1 on the cardiomyocytes was demonstrated. The enhancement of the decrease in pH and cell injury induced by endothelin-1 was counteracted by the endothelin ET (A) receptor antagonist BQ123 or by maintaining the pH of the medium by the addition of 50 mM HEPES. |
1(0,0,0,1) | Details |