| Name | heme oxygenase 1 |
|---|---|
| Synonyms | HMOX 1; HMOX1; HMOX1 protein; HO; HO 1; HO1; Heme oxygenase (Decycling) 1; Heme oxygenase (Decyclizing) 1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16378625 | Wu CC, Hsu MC, Hsieh CW, Lin JB, Lai PH, Wung BS: Upregulation of heme oxygenase-1 by via the phosphatidylinositol 3-kinase/Akt and ERK pathways. Life Sci. 2006 May 15;78(25):2889-97. Epub 2005 Dec 27. The inhibition of intracellular ROS production by (NAC), (GSH), superoxide dismutase (SOD), catalase and the mitochondrial complex I inhibitor, rotenone, results in a decrease in -dependent HO-1 expression. |
39(0,1,1,9) | Details |
| 19131585 | Han Z, Varadharaj S, Giedt RJ, Zweier JL, Szeto HH, Alevriadou BR: Mitochondria-derived reactive species mediate heme oxygenase-1 expression in sheared endothelial cells. J Pharmacol Exp Ther. 2009 Apr;329(1):94-101. Epub 2009 Jan 8. The mitochondrial electron transport chain inhibitors, myxothiazol, rotenone, or antimycin A, and the mitochondria-targeted antioxidant peptide, Szeto-Schiller (SS)-31, which scavenges O (2)(*-), peroxide (H (2) O (2)), and markedly inhibited the increase in HO-1 expression. |
88(1,1,1,8) | Details |
| 19735655 | Quesada A, Micevych P, Handforth A: C-terminal mechano growth factor protects neurons: a novel peptide that induces heme oxygenase-1. Exp Neurol. 2009 Dec;220(2):255-66. Epub 2009 Sep 6. We show that a short 24-amino acid C-terminal peptide of MGF (MGF24) upregulates heme oxygenase-1 (HO-1) expression and protects SH-SY5Y cells against apoptosis and cell loss induced by three DA cell-specific neurotoxins: (6-OHDA), 1-methyl-4-phenylpyridinium (MPP (+)), and rotenone. |
10(0,0,1,5) | Details |
| 18452993 | Cho HS, Kim S, Lee SY, Park JA, Kim SJ, Chun HS: Protective effect of the green tea component, L-theanine on environmental toxins-induced neuronal cell death. Neurotoxicology. 2008 Jul;29(4):656-62. Epub 2008 Mar 20. In addition, L-theanine partially prevented both rotenone- and dieldrin-induced heme oxygenase-1 (HO-1) up-regulation. |
6(0,0,1,1) | Details |
| 17540012 | Egea J, Rosa AO, Cuadrado A, Garcia AG, Lopez MG: Nicotinic receptor activation by epibatidine induces heme oxygenase-1 and protects chromaffin cells against oxidative stress. J Neurochem. 2007 Sep;102(6):1842-52. Epub 2007 Jun 1. In this context, we investigated here if the exposure of bovine chromaffin cells to the potent nAChR agonist epibatidine protected against rotenone (30 micromol/L) plus oligomycin (10 micromol/L) (rot/oligo) toxicity, an in vitro model of mitochondrial ROS production. |
5(0,0,0,5) | Details |
| 20227863 | He M, Siow RC, Sugden D, Gao L, Cheng X, Mann GE: Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: A role for Nrf2 in vascular protection in diabetes. Nutr Metab Cardiovasc Dis. 2010 Mar 12. Inhibition of ROS production with the scavenger Tiron or inhibitors of flavoproteins (diphenylene iodonium) and oxidase (apocynin), but not eNOS (l-NAME) or mitochondria complex I (rotenone) abrogated HO-1 induction by AGE-BSA. |
3(0,0,0,3) | Details |
| 17885094 | Canas N, Valero T, Villarroya M, Montell E, Verges J, Garcia AG, Lopez MG: protects SH-SY5Y cells from oxidative stress by inducing heme oxygenase-1 via phosphatidylinositol 3-kinase/Akt. J Pharmacol Exp Ther. 2007 Dec;323(3):946-53. Epub 2007 Sep 20. Cell death caused by a combination of 10 microM rotenone plus 1 microM oligomycin-A (Rot/oligo) was also reduced by CS at concentrations ranging from 0.3 to 100 microM; in this toxicity model, maximum protection was achieved at 3 microM (48%). |
3(0,0,0,3) | Details |
| 16678137 | Ho HK, Jia Y, Coe KJ, Gao Q, Doneanu CE, Hu Z, Bammler TK, Beyer RP, Fausto N, Bruschi SA, Nelson SD: Cytosolic heat shock proteins and heme oxygenase-1 are preferentially induced in response to specific and localized intramitochondrial damage by tetrafluoroethylcysteine. Biochem Pharmacol. 2006 Jun 28;72(1):80-90. Epub 2006 Mar 29. Results of these studies revealed a HSP response that was significantly stronger than other well-characterized hepatotoxicants including diquat and rotenone. |
2(0,0,0,2) | Details |
| 15650392 | Bundy RE, Hoare GS, Kite A, Beach J, Yacoub M, Marczin N: Redox regulation of p38 MAPK activation and expression of ICAM-1 and heme oxygenase-1 in human alveolar epithelial (A549) cells. Antioxid Redox Signal. 2005 Jan-Feb;7(1-2):14-24. The mitochondrial complex I and III inhibitors, rotenone and antimycin A, and allopurinol partially inhibited H2O2- but not TNFalpha-induced p38 activation. |
2(0,0,0,2) | Details |
| 16651638 | Watanabe N, Zmijewski JW, Takabe W, Umezu-Goto M, Le Goffe C, Sekine A, Landar A, Watanabe A, Aoki J, Arai H, Kodama T, Murphy MP, Kalyanaraman R, Darley-Usmar VM, Noguchi N: Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive species generation in endothelial cells. Am J Pathol. 2006 May;168(5):1737-48. ERK activation was attenuated by inhibitors of the electron transport chain proton pumps (rotenone and antimycin A) and an uncoupler (carbonyl p-trifluoromethoxyphenylhydrazone), suggesting that mitochondrial inner membrane potential plays a key role in the signaling pathway. Inhibition of ERK activation with MEK inhibitors (PD98059 or U0126) diminished induction of the antioxidant enzyme heme oxygenase-1. |
1(0,0,0,1) | Details |