| Name | PHGPx |
|---|---|
| Synonyms | GPX 4; MCSP; GPX4; GPX4 protein; Glutathione peroxidase 4; Glutathione peroxidase 4 (phospholipid hydroperoxidase); PHGPx; Phospholipid hydroperoxidase… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19818760 | Kadota Y, Suzuki S, Ideta S, Fukinbara Y, Kawakami T, Imai H, Nakagawa Y, Sato M: Enhanced metallothionein gene expression induced by mitochondrial oxidative stress is reduced in phospholipid hydroperoxide peroxidase-overexpressed cells. Eur J Pharmacol. 2010 Jan 25;626(2-3):166-70. Epub 2009 Oct 8. These cells were treated with respiratory inhibitors, including rotenone and 2, 4-dinitrophenol; under these conditions, the PHGPx-ov cells were more resistant to cell death than the control cells. |
40(0,1,2,5) | Details |
| 9988735 | Arai M, Imai H, Koumura T, Yoshida M, Emoto K, Umeda M, Chiba N, Nakagawa Y: Mitochondrial phospholipid hydroperoxide peroxidase plays a major role in preventing oxidative injury to cells. J Biol Chem. 1999 Feb 19;274(8):4924-33. Phospholipid hydroperoxide peroxidase (PHGPx) is synthesized as a long form (L-form; 23 kDa) and a short form (S-form; 20 kDa). Cell death caused by mitochondrial injury due to (KCN) or rotenone (chemical hypoxia) was considerably suppressed in the M15 cells, whereas the L9 cells and control RBL-2H3 cells (S1 cells, transfected with the vector alone) succumbed to the cytotoxic effects of KCN. |
4(0,0,0,4) | Details |