Protein Information

Name kynurenine 3 hydroxylase
Synonyms KMO; KMO protein; Kynurenine 3 hydroxylase; Kynurenine 3 monooxygenase; dJ317G22.1; kynurenine 3 monooxygenase (kynurenine 3 hydroxylase); KMO proteins; Kynurenine 3 hydroxylases…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
4389188 Okamoto H, Hayaishi O: Solubilization and partial purification of kynurenine hydroxylase from mitochondrial outer membrane and its electron donors. Arch Biochem Biophys. 1969 May;131(2):603-8.

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5563754 Okamoto H: Influence of L-thyroxine on kynurenine 3-hydroxylase, monoamine oxidase, and rotenone-insensitive NADH-cytochrome c reductase in mitochondrial outer membrane. Biochem Biophys Res Commun. 1971 May 21;43(4):827-33.
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5499970 Gear AR: Inner- and outer-membrane enzymes of mitochondria during liver regeneration. Biochem J. 1970 Dec;120(3):577-87.

The behaviour of the rotenone-insensitive, NADH cytochrome c reductase did not parallel the other outer-membrane enzymes for intact mitochondria, but did so when assayed in highly purified fractions of outer membrane.
However, the specific activities of monoamine oxidase and kynurenine hydroxylase, both outer-membrane markers, fell by 67% and 49% respectively from their control values at 4 days after operation, and returned to normal by about 3 weeks. 4.
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4397476 Hayaishi O, Okamoto H: Localization and some properties of kynurenine-3-hydroxylase and kynurenine aminotransferase. Am J Clin Nutr. 1971 Jul;24(7):805-6.

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4094191 Yoshida T, Yamamoto T, Matsuura Y, Kuroiwa Y: Early effects of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene on mitochondrial outer membrane enzyme activities of rat liver. Jpn J Pharmacol. 1985 Dec;39(4):475-9.


The findings indicate that type B MAO and kynurenine 3-hydroxylase which reside in the outer mitochondrial membranes are susceptible to 2-AAF during the early stages of its hepatocarcinogenesis.
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