| Name | dopamine transporter |
|---|---|
| Synonyms | DA transporter; DAT1; DAT; DAT 1; Dopamine transporter; SLC6A3; Sodium dependent dopamine transporter; Dopamine transporters… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18289173 | Lin CH, Huang JY, Ching CH, Chuang JI: reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats. J Pineal Res. 2008 Mar;44(2):205-13. |
112(1,2,2,2) | Details |
| 15265589 | Yang Y, Liu X, Ding JH, Sun J, Long Y, Wang F, Yao HH, Hu G: Effects of iptakalim on rotenone-induced cytotoxicity and release from PC12 cells. Neurosci Lett. 2004 Aug 5;366(1):53-7. These results suggest that iptakalim may open mitochondrial K (ATP) channels to modulate dopamine transporter and reduce extracellular levels, thereby it protecting PC12 cells against rotenone-induced injury. |
112(1,2,2,2) | Details |
| 9125443 | Ferrante RJ, Schulz JB, Kowall NW, Beal MF: Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra. Brain Res. 1997 Apr 4;753(1):157-62. These results are consistent with prior reports suggesting that the selective vulnerability of the substantia nigra to MPTP involves both uptake by the dopamine transporter as well as complex I inhibition, and they show that rotenone produces a unique pattern of central nervous system damage. |
31(0,1,1,1) | Details |
| 12358732 | Wu J, Chan P, Schroeder KM, Ellsworth K, Partridge LD: 1-Methyl-4-phenylpridinium (MPP+)-induced functional run-down of (A) receptor-mediated currents in acutely dissociated dopaminergic neurons. J Neurochem. 2002 Oct;83(1):87-99. The MPP+-induced I run-down can be prevented by a DA transporter inhibitor, mazindol, and can be mimicked by a metabolic inhibitor, rotenone. |
31(0,1,1,1) | Details |
| 18206288 | Hirata Y, Suzuno H, Tsuruta T, Oh-hashi K, Kiuchi K: The role of dopamine transporter in selective toxicity of and rotenone. Toxicology. 2008 Feb 28;244(2-3):249-56. Epub 2007 Dec 3. |
20(0,0,3,5) | Details |
| 8719427 | Bougria M, Vitorica J, Cano J, Machado A: Implication of dopamine transporter system on 1-methyl-4-phenylpyridinium and rotenone effect in striatal synaptosomes. Eur J Pharmacol. 1995 Nov 30;291(3):407-15. |
6(0,0,1,1) | Details |
| 18579341 | Sai Y, Wu Q, Le W, Ye F, Li Y, Dong Z: Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered metabolism. Toxicol In Vitro. 2008 Sep;22(6):1461-8. Epub 2008 May 4. Tyrosine hydroxylase (TH) and vesicular monoamine transporter 2 (VMAT (2)) were markedly down-regulated, and dopamine transporter (DAT) was up-regulated in the cells. |
2(0,0,0,2) | Details |
| 12151787 | Lehmensiek V, Tan EM, Schwarz J, Storch A: Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro. Neuroreport. 2002 Jul 19;13(10):1279-83. We demonstrate that expression of all alpha-synuclein isoforms enhances toxicity of general complex I inhibition (rotenone), but only the expression of mutant alpha-synucleins induces significant increased DAT-dependent toxicity of very low concentrations of MPP+ compared to wild-type protein. |
2(0,0,0,2) | Details |
| 11996892 | Maragos WF, Zhu J, Chesnut MD, Dwoskin LP: Mitochondrial toxin inhibition of [(3) H] uptake into rat striatal synaptosomes. Biochem Pharmacol. 2002 Apr 15;63(8):1499-505. The purpose of this study was to determine whether mitochondrial inhibition alters dopamine transporter (DAT) function. Although all of the toxins inhibited [(3) H] DA uptake, there was a large variation in their inhibitory potencies, the rank order being rotenone>> azide> 3-NP>> |
1(0,0,0,1) | Details |
| 11198300 | Lotharius J, O'Malley KL: Role of mitochondrial dysfunction and -dependent oxidative stress in amphetamine-induced toxicity. Ann Neurol. 2001 Jan;49(1):79-89. In contrast, when primary cultures of dopaminergic neurons were exposed to AMPH in the presence of subtoxic doses of the mitochondrial complex I inhibitor rotenone, cell death was dramatically increased, mimicking the effects of a known parkinsonism-inducing toxin. As in earlier studies, AMPH rapidly redistributed vesicular DA to the cytoplasm, where it underwent outward transport through the DA transporter. |
1(0,0,0,1) | Details |
| 15198987 | Jiang H, Ren Y, Zhao J, Feng J: Parkin protects human dopaminergic neuroblastoma cells against -induced apoptosis. Hum Mol Genet. 2004 Aug 15;13(16):1745-54. Epub 2004 Jun 15. Inhibiting DA uptake through dopamine transporter or treating the cell with antioxidants significantly reduced oxidative stress and toxicity. Here, we show that overexpression of parkin protected human DA neuroblastoma cell line (SH-SY5Y) against apoptosis induced by DA or 6-OHDA, but not by H (2) O (2) or rotenone. |
1(0,0,0,1) | Details |
| 12428729 | Stephans SE, Miller GW, Levey AI, Greenamyre JT: Acute mitochondrial and chronic toxicological effects of 1-methyl-4-phenylpyridinium in human neuroblastoma cells. Neurotoxicology. 2002 Oct;23(4-5):569-80. A human neuroblastoma cell line expressing the dopamine transporter (DAT) was utilized to examine the effects of MPP+ on acute physiologic responses and subsequent cell death. The lipophilic complex I inhibitor, rotenone, increased excretion in both cell lines. |
1(0,0,0,1) | Details |
| 10969076 | Lotharius J, O'Malley KL: The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular oxidation. J Biol Chem. 2000 Dec 8;275(49):38581-8. Although a mean lethal dose of MPP (+) led to ROS production in identified dopaminergic neurons, toxic doses of the Complex I inhibitor rotenone did not. Concurrent with ROS formation, MPP (+) redistributed vesicular DA to the cytoplasm prior to its extrusion from the cell by reverse transport via the DA transporter. |
1(0,0,0,1) | Details |
| 17447424 | Ceravolo R, Sgado P, Frosini D, Corsini GU: Assessing neuroprotection in Parkinson's disease: from the animal models to molecular neuroimaging in vivo. J Neural Transm Suppl. 2006;(71):133-41. The first group comprehends 6-OHDA e MPTP and recently rotenone, paraquat and epoxomicin treated animals that shows some of human disease characteristics. Recently has emerged the important role of neuroimaging (Dopamine Transporter SPECT, 18FDopa-PET) as surrogate biomarker of PD progression. |
1(0,0,0,1) | Details |
| 17131421 | Fountaine TM, Wade-Martins R: RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP (+) toxicity and reduces transport. J Neurosci Res. 2007 Feb 1;85(2):351-63. We show that alpha-synuclein knockdown has no effect on cellular survival either under normal growth conditions over 5 days or in the presence of the mitochondrial inhibitor rotenone. Knockdown does, however, confer resistance to the dopamine transporter (DAT)-dependent neurotoxin N-methyl-4-phenylpyridinium (MPP (+)). |
1(0,0,0,1) | Details |
| 12763610 | Fonck C, Baudry M: Rapid reduction of ATP synthesis and lack of free radical formation by MPP+ in rat brain synaptosomes and mitochondria. Brain Res. 2003 Jun 13;975(1-2):214-21. MPTP is metabolized in the brain to MPP (+), which is taken up into dopaminergic neurons via the dopamine transporter and assumed to impair mitochondrial function. For comparison, the respiratory toxins FCCP, a analog that uncouples mitochondrial ATP production, and rotenone, a NADH dehydrogenase inhibitor, were also tested. |
1(0,0,0,1) | Details |
| 17376993 | Mount MP, Lira A, Grimes D, Smith PD, Faucher S, Slack R, Anisman H, Hayley S, Park DS: Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons. J Neurosci. 2007 Mar 21;27(12):3328-37. After this initial finding, we found that IFN-gamma-deficient mice displayed attenuated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced substantia nigra pars compacta dopaminergic cell loss along with reduced loss of striatal tyrosine hydroxylase and dopamine transporter fiber density. To examine more mechanistically the role of IFN-gamma in microglial activation, we evaluated the interactions between microglia and dopaminergic neurons in an in vitro mixed microglia/midbrain neuron rotenone-induced death paradigm. |
1(0,0,0,1) | Details |
| 19681169 | Tapias V, Cannon JR, Greenamyre JT: treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model. J Neurosci Res. 2010 Feb 1;88(2):420-7. |
0(0,0,0,0) | Details |
| 16725203 | Kou J, Klorig DC, Bloomquist JR: Potentiating effect of the ATP-sensitive potassium channel blocker glibenclamide on complex I inhibitor neurotoxicity in vitro and in vivo. Neurotoxicology. 2006 Sep;27(5):826-34. Epub 2006 Apr 28. We measured the ability of mitochondrial inhibitors of complexes I (rotenone, MPP (+), and HPP (+)), II (amdro), IV (Na and an uncoupler (dinoseb) to release preloaded from murine striatal synaptosomes. |
0(0,0,0,0) | Details |
| 12675912 | Shang T, Uihlein AV, Van Asten J, Kalyanaraman B, Hillard CJ: 1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3. J Neurochem. 2003 Apr;85(2):358-67. In contrast, the effects of rotenone are unaffected by |
0(0,0,0,0) | Details |
| 17018646 | Ramachandiran S, Hansen JM, Jones DP, Richardson JR, Miller GW: Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation. Toxicol Sci. 2007 Jan;95(1):163-71. Epub 2006 Oct 3. |
0(0,0,0,0) | Details |