| Name | ribonucleotide reductase (protein family or complex) |
|---|---|
| Synonyms | Ribonucleotide reductase; Ribonucleotide reductases |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7646435 | O'Donnell VB, Spycher S, Azzi A: Involvement of oxidants and oxidant-generating enzyme (s) in tumour-necrosis-factor-alpha-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain. Biochem J. 1995 Aug 15;310 ( Pt 1):133-41. Using specific inhibitors, we ruled out involvement of several oxidant-generating enzymes [cyclo-oxygenase (indomethacin), cytochrome P-450 synthase (NG-methyl- oxidase (iodonium diphenyl), xanthine oxidase (allopurinol), ribonucleotide reductase (hydroxyurea)] in TNF alpha-mediated apoptosis of the murine fibrosarcoma line, L929. We also demonstrated no role for mitochondrial-derived radicals/respiratory chain in the lytic pathway using specific inhibitors/uncouplers (rotenone, KCN, carboxin, fluoroacetate, antimycin, carbonyl p-trifluoromethoxyphenylhydrazone) and chloramphenicol-derived respiration-deficient cells. |
1(0,0,0,1) | Details |
| 16300973 | Bal-Price A, Gartlon J, Brown GC: stimulates PC12 cell proliferation via and inhibits at higher concentrations mainly via energy depletion. Nitric Oxide. 2006 May;14(3):238-46. Epub 2005 Nov 21. Cytostatic concentrations of DETA/NO strongly inhibited respiration of PC12 cells, and specific respiratory inhibitors (rotenone, myxothiazol, or azide) caused complete cytostasis. |
0(0,0,0,0) | Details |