Protein Information

Name arginase
Synonyms ARG 1; ARG1; Arginase; Arginase 1; Arginine amidinase; Canavanase; Liver type arginase; Type I arginase…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
16085056 Bae SY, Xu Q, Hutchinson D, Colton CA: Y+ and y+ L arginine transporters in neuronal cells expressing tyrosine hydroxylase. Biochim Biophys Acta. 2005 Aug 15;1745(1):65-73. Epub 2005 Feb 9.

Arginine is a semi-essential amino acid that serves as sole substrate for enzymes involved in diverse cell processes including redox balance via nitric oxide synthase (NOS) and cell proliferation via arginase.
Short term exposure to the oxidizing agents, rotenone and Angeli's salt, but not FeSO4, increases arginine transport.
1(0,0,0,1) Details
19103678 Dedkova EN, Blatter LA: Characteristics and function of cardiac mitochondrial nitric oxide synthase. J Physiol. 2009 Feb 15;587(Pt 4):851-72. Epub 2008 Dec 22.

Collapsing the mitochondrial membrane potential with the protonophore FCCP or blocking the mitochondrial Ca (2+) uniporter with Ru360 as well as blocking the respiratory chain with rotenone or antimycin A in combination with oligomycin inhibited mitochondrial NO production.
Inhibition of mitochondrial arginase to limit L-arginine availability resulted in 50% inhibition of Ca (2+)-induced ROS production.
1(0,0,0,1) Details