Protein Information

Name hydroxyacyl CoA dehydrogenase
Synonyms 2 enoyl CoA hydratase; Hydroxyacyl CoA dehydrogenase; HADH; 2 enoyl Coenzyme A hydratase; HADHB; Hydroxyacyl Coenzyme A dehydrogenase; MSTP029; TP beta…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
7797367 Fukushima T, Isobe A, Joho N, Shiwaku K, Yamane Y, Torii M: The fatty acids of each lipid fraction and their use in providing energy source of the plerocercoid of Spirometra erinacei. Int J Parasitol. 1995 Jan;25(1):15-21.

Michaelis constants (Km) of beta-hydroxyacyl-CoA dehydrogenase (HAD), NADH: ubiquinone oxidoreductase (complex I) (NADH: ferricyanide reaction) and complex I (NADH: ubiquinone reaction) for NADH were 20.6, 50 and 13.3 microM, respectively.
The ATP production in mitochondria of the plerocercoids was accelerated by adding ADP and inhibited by adding such electron transport system inhibitors as rotenone, antimycin A and sodium cyanide.
1(0,0,0,1) Details
15704879 Bufetov EN, Polygalova OO, Ponomareva AA: [Ultrastructural characteristics of mitochondria during cell adaptation to rotenone]. Tsitologiia. 2004;46(11):985-92.

A study was made of respiration, heat production, K+ output and ultrastructure of wheat root cells treated for 6 h with rotenone (10 microM), an inhibitor of HADH-ubiquinone oxidoreductase (Complex I).
81(1,1,1,1) Details
1668635 Kunz WS: Application of the theory of steady-state flux control to mitochondrial beta-oxidation. Biomed Biochim Acta. 1991;50(12):1143-57.

The theory of steady-state flux control was applied to characterize the regulation of beta-oxidation flux in uncoupled rat liver mitochondria oxidizing palmitoylcarnitine in the presence of rotenone, malonate and the beta-hydroxybutyrate/acetoacetate redox buffer.
It was found that at low flux rates the flux control was distributed mainly between acyl-CoA dehydrogenase and beta-hydroxyacyl-CoA dehydrogenase (Ci = 0.89).
1(0,0,0,1) Details