| Name | dopa decarboxylase |
|---|---|
| Synonyms | AADC; Aromatic L amino acid decarboxylase; DDC; DDC protein; DOPA decarboxylase; Putative L Dopa decarboxylase; dopa decarboxylase (aromatic L amino acid decarboxylase); Aromatic L amino acid decarboxylases… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19558709 | Ming M, Li X, Fan X, Yang D, Li L, Chen S, Gu Q, Le W: Retinal pigment epithelial cells secrete neurotrophic factors and synthesize possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease. J Transl Med. 2009 Jun 28;7:53. RESULTS: We report here: (1) CM from RPE cells can secret trophic factors GDNF and BDNF, and protect DAergic neurons against the 6-OHDA- and rotenone-induced cell injury; (2) cultured RPE cells express L-dopa decarboxylase (DDC) and synthesize DA; (3) RPE cells attached to microcarriers can survive in the host striatum and improve the AIR in 6-OHDA-lesioned animal model of PD; (4) GDNF and BDNF levels are found significantly higher in the RPE cell-grafted tissues. |
31(0,1,1,1) | Details |
| 1661844 | Dagani F, Ferrari R, Anderson JJ, Chase TN: does not affect electron transfer chain enzymes and respiration of rat muscle mitochondria. Mov Disord. 1991;6(4):315-9. In order to determine whether these effects are only dependent on the disease or are partially due to its therapy, the effects of methyl ester and benserazide, a peripheral dopa decarboxylase inhibitor, were studied on various parameters related to energy metabolism in rat skeletal muscle mitochondria. The maximum activities related to complexes of the respiratory chain: rotenone-sensitive -cytochrome c reductase, -cytochrome c reductase, cytochrome c oxidase, state 3, state 4, uncoupled state, and respiratory control ratio were measured after 17-19 days of treatment. |
1(0,0,0,1) | Details |
| 11295535 | Kristal BS, Conway AD, Brown AM, Jain JC, Ulluci PA, Li SW, Burke WJ: Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria. Free Radic Biol Med. 2001 Apr 15;30(8):924-31. which is metabolized to by dopa decarboxylase, is the primary therapy for PD, but may also contribute to disease progression. |
1(0,0,0,1) | Details |