| Name | p47 phox |
|---|---|
| Synonyms | 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF 1; NCF 47K; NCF1; Neutrophil NADPH oxidase factor 1; p47 phox; Adaptor protein p47phox… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18638544 | Rathore R, Zheng YM, Niu CF, Liu QH, Korde A, Ho YS, Wang YX: Hypoxia activates oxidase to increase [ROS] i and [Ca2+] i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells. Free Radic Biol Med. 2008 Nov 1;45(9):1223-31. Epub 2008 Jun 21. In this study, using Western blot analysis we found that the major Nox subunits Nox1, Nox4, p22 (phox), p47 (phox), and p67 (phox) were equivalently expressed in mouse pulmonary and systemic (mesenteric) arteries. Inhibition of mitochondrial ROS generation with rotenone or myxothiazol prevented hypoxic activation of Nox. |
2(0,0,0,2) | Details |
| 16024921 | Yang T, Zhang A, Honeggar M, Kohan DE, Mizel D, Sanders K, Hoidal JR, Briggs JP, Schnermann JB: Hypertonic induction of COX-2 in collecting duct cells by reactive species of mitochondrial origin. J Biol Chem. 2005 Oct 14;280(41):34966-73. Epub 2005 Jul 17. The increases in ROSs in response to hypertonic treatment were completely blocked by any one of the mitochondrial inhibitors tested, such as rotenone, thenoyltrifluoroacetone, or carbonyl m-chlorophenylhydrazone, associated with remarkable inhibition of COX-2 expression. |
0(0,0,0,0) | Details |
| 16762927 | Hidalgo C, Sanchez G, Barrientos G, Aracena-Parks P: A transverse tubule oxidase activity stimulates release from isolated triads via ryanodine receptor type 1 S -glutathionylation. J Biol Chem. 2006 Sep 8;281(36):26473-82. Epub 2006 Jun 8. Immunohistochemical determinations with NOX antibodies showed that the gp91 (phox) membrane subunit and the cytoplasmic regulatory p47 (phox) subunit co-localized in transverse tubules of adult mice fibers with the alpha1s subunit of dihydropyridine receptors. or elicited and peroxide generation by isolated triads; both activities were inhibited by NOX inhibitors but not by rotenone. |
1(0,0,0,1) | Details |
| 12388366 | Parinandi NL, Kleinberg MA, Usatyuk PV, Cummings RJ, Pennathur A, Cardounel AJ, Zweier JL, Garcia JG, Natarajan V: Hyperoxia-induced NAD (P) H oxidase activation and regulation by MAP kinases in human lung endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2003 Jan;284(1):L26-38. Epub 2002 Jul 26. Exposure of HPAECs to hyperoxia for 1, 3, and 12 h increased the generation of which was blocked by diphenyleneiodonium but not by rotenone or Immunohistocytochemistry and Western blotting revealed the presence of gp91, p67 phox, p22 phox, and p47 phox subcomponents of oxidase in HPAECs. |
1(0,0,0,1) | Details |
| 19371610 | Mo Y, Wan R, Chien S, Tollerud DJ, Zhang Q: Activation of endothelial cells after exposure to ambient ultrafine particles: the role of oxidase. Toxicol Appl Pharmacol. 2009 Apr 15;236(2):183-93. Epub 2009 Feb 5. Our results showed that UFPs, at a non-toxic dose, induced reactive species (ROS) generation in mouse pulmonary microvascular endothelial cells (MPMVEC) that was inhibited by pre-treatment with the ROS scavengers or inhibitors, but not with the mitochondrial inhibitor, rotenone. Moreover, Western blot and immunofluorescence staining results showed that MPMVEC treated with UFPs resulted in the translocation of cytosolic proteins of oxidase, p47 (phox), p67 (phox) and rac 1, to the plasma membrane. |
1(0,0,0,1) | Details |
| 18522491 | Wenzel P, Mollnau H, Oelze M, Schulz E, Wickramanayake JM, Muller J, Schuhmacher S, Hortmann M, Baldus S, Gori T, Brandes RP, Munzel T, Daiber A: First evidence for a crosstalk between mitochondrial and oxidase-derived reactive species in nitroglycerin-triggered vascular dysfunction. Antioxid Redox Signal. 2008 Aug;10(8):1435-47. tolerance was induced by nitroglycerin infusion in male Wistar rats (100 microg/h/4 day) and in C57/Bl6, p47 (phox/) and gp91 (phox/) mice (50 microg/h/4 day). Vice versa, tolerance was attenuated by co-treatment with the respiratory chain complex I inhibitor rotenone (100 microg/h/4 day) or the mitochondrial permeability transition pore blocker cyclosporine A (50 microg/h/4 day). |
1(0,0,0,1) | Details |
| 18006827 | Xia C, Meng Q, Liu LZ, Rojanasakul Y, Wang XR, Jiang BH: Reactive species regulate angiogenesis and tumor growth through vascular endothelial growth factor. Cancer Res. 2007 Nov 15;67(22):10823-30. This elevated ROS production was inhibited by oxidase inhibitor diphenylene iodonium (DPI) and mitochondria electron chain inhibitor rotenone in the cells. To further analyze the source of ROS production, we found that ovarian cancer cells have much higher expression of NOX4 oxidase, and that specific inhibition of oxidase subunit p47 (phox) diminished ROS production. |
1(0,0,0,1) | Details |
| 17881465 | Ding G, Zhang A, Huang S, Pan X, Zhen G, Chen R, Yang T: ANG II induces c-Jun NH2-terminal kinase activation and proliferation of human mesangial cells via redox-sensitive transactivation of the EGFR. Am J Physiol Renal Physiol. 2007 Dec;293(6):F1889-97. Epub 2007 Sep 19. In contrast, inhibitors of other oxidant-producing enzymes, including the mitochondrial complex I inhibitor rotenone, the xanthine oxidase inhibitor allopurinol, the cyclooxygenase inhibitor indomethacin, the lipoxygenase inhibitor nordihydroguiaretic acid, the cytochrome P-450 oxygenase inhibitor ketoconazole, and the synthase inhibitor N (G)-nitro- methyl ester, were without effect. ANG II induced translocation of p47 (phox) and p67 (phox) from the cytosol to the membrane. |
1(0,0,0,1) | Details |
| 10837166 | Kaul P, Biagioli MC, Singh I, Turner RB: Rhinovirus-induced oxidative stress and interleukin-8 elaboration involves p47-phox but is independent of attachment to intercellular adhesion molecule-1 and viral replication. J Infect Dis. 2000 Jun;181(6):1885-90. Epub 2000 Jun 5. Treatment of cells with diphenylene iodonium inhibited virus-induced oxidative stress and IL-8 elaboration, but allopurinol, and rotenone had no effect. |
3(0,0,0,3) | Details |