| Name | cytochrome b |
|---|---|
| Synonyms | COB; CYTB; Cytochrome b; Cytochrome b of complex III; MT CYB; MTCYB; mitochondrially encoded cytochrome b; Cytochrome bs… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7774132 | Takeshige K: formation and lipid peroxidation by the mitochondrial electron-transfer chain]. Rinsho Shinkeigaku. 1994 Dec;34(12):1269-71. is a stoichiometric precursor of mitochondrial H2O2 because the ratio of O2-/H2O2 generation rates is close to 2.0 and is generated by an autoxidizable component in the NADH dehydrogenase and the -cytochrome b site. Electrons from are supplied to the reactions from a component between the substrate site and the rotenone-sensitive site of the NADH dehydrogenase. |
1(0,0,0,1) | Details |
| 16742609 | Lloyd D, Chance B: Electron transport in mitochondria isolated from the flagellate Polytomella caeca. Biochem J. 1968 May;107(6):829-837. Electron transport is inhibited by antimycin A, rotenone, piericidin A and 3. Spectral data indicate that antimycin A inhibits the reoxidation of reduced cytochrome b. 4. |
1(0,0,0,1) | Details |
| 4985609 | Wilson DF, Dutton PL: Energy dependent changes in the oxidation-reduction potential of cytochrome b. Biochem Biophys Res Commun. 1970 Apr 8;39(1):59-64. |
1(0,0,0,1) | Details |
| 821392 | Kot EJ, Olson VL, Rolewic LJ, McClary DO: An alternate respiratory pathway in Candida albicans. Antonie Van Leeuwenhoek. 1976;42(1-2):33-48. The high rate of respiration of C. albicans in the presence of inhibitors for three sites of electron transport in the conventional oxidative pathway, the inhibition of this respiration by SHAM and its loss by the absence of cytochrome b, indicate an alternate oxidative pathway in this organism which crosses the conventional one at cytochrome b. Usual concentrations of antimycin A, rotenone and EDTA, individually or in combination, reduced aerobic growth rate and cell yield of Candida albicans to about half its normal level and to about the levels of previously-described -negative, cytochrome-complete and aa3-deficient variants which were little affected by the inhibitors. |
1(0,0,0,1) | Details |
| 1768276 | Lund BO, Miller DM, Woods JS: Mercury-induced H2O2 production and lipid peroxidation in vitro in rat kidney mitochondria. Biochem Pharmacol. 1991 Dec 11;42 Suppl:S181-7. In mitochondria supplemented with a respiratory chain substrate or / and an electron transport inhibitor (antimycin A (AA) or rotenone), Hg (II) (30 nmol/mg protein) increased H2O2 formation approximately 4-fold at the -cytochrome b region (AA-inhibited) and 2-fold at the NADH dehydrogenase region (rotenone-inhibited). |
82(1,1,1,2) | Details |
| 1664494 | Benzi G, Curti D, Pastoris O, Marzatico F, Villa RF, Dagani F: Sequential damage in mitochondrial complexes by peroxidative stress. Neurochem Res. 1991 Dec;16(12):1295-302. The cerebral peroxidative stress induces: (a) initially, a decrease in brain GSH concentration concomitant with a decrease in the mitochondrial activity of cytochrome oxidase of aa3-type (complex IV), without changes in and cytochrome b populations; (b) subsequently, an alteration in the transfer molecule cytochrome c and, finally, in rotenone-sensitive -cytochrome c reductase (complex I) and succinate dehydrogenase (complex II). |
37(0,1,2,2) | Details |
| 7236242 | Takayanagi R, Takeshige K, Minakami S: - and -dependent lipid peroxidation in bovine heart submitochondrial particles. Biochem J. 1980 Dec 15;192(3):853-60. Reduced uniquinone-2 also inhibited the peroxidation, but duroquinol, which reduces cytochrome b without reducing endogenous uniquinone, did not. The reaction was stimulated by rotenone and inhibited by antimycin A when the input was fast, whereas it was not affected by the inhibitors when the input was slow. |
1(0,0,0,1) | Details |
| 215122 | Ragan CI, Heron C: The interaction between mitochondrial NADH-ubiquinone oxidoreductase and -cytochrome c oxidoreductase. Biochem J. 1978 Sep 15;174(3):783-90. Experiments on the inhibition of the -cytochrome c oxidoreductase activity of mixtures of Complexes I and III by rotenone and antimycin indicate that electron transfer between a unit of Complex I-Complex III and extra molecules of Complexes I or III does not contribute to the overall rate of cytochrome c reduction. 3. The reduction by of the cytochrome b of mixtures of Complexes I and III is biphasic. |
1(0,0,0,1) | Details |
| 5053270 | Pedersen JI, Flatmark T: Studies on the energy state of isolated brown adipose tissue mitochondria. Biochim Biophys Acta. 1972 Aug 17;275(2):135-47. The cytochrome b complex as a probe of the energy state of the mitochondrial inner membrane. |
1(0,0,0,1) | Details |
| 3571184 | Nishino H, Ito A: Subcellular distribution of OM cytochrome b-mediated -semidehydroascorbate reductase activity in rat liver. J Biochem. 1986 Dec;100(6):1523-31. The ratio of the OM cytochrome b-mediated activities of -SDA reductase to rotenone-insensitive -cytochrome c reductase varied among these tissues. |
248(3,3,3,8) | Details |
| 1148252 | Higuti T, Mizuno S, Muraoka S: Stepwise reduction of cytochromes b-562, b-566 and b-558 in rat liver mitochondria. Biochim Biophys Acta. 1975 Jul 8;396(1):36-47. Addition of to rotenone-KCN-inhibited and ATP-treated rat liver mitochondria under conditions where cytochromes b-566, b-562, c+c1 and a+a3 were already fully reduced, caused reduction of cytochrome b-558 (having an alpha-band at 558 nm, a beta-band at 527 nm and a gamma-band at 426 nm at room temperature) after exhaustion of molecular in the reaction medium, without any contribution from a long-wavelength species (cytochrome b-566). 4. |
82(1,1,1,2) | Details |
| 4340268 | Norling B, Nelson BD, Nordenbrand K, Ernster L: Evidence for the occurrence in submitochondrial particles of a dual respiratory chain containing different forms of cytochrome b. Biochim Biophys Acta. 1972 Jul 12;275(1):18-32. |
1(0,0,0,1) | Details |
| 177046 | La Monica RF, Marrs BL: The branched respiratory system of photosynthetically grown Rhodopseudomonas capsulata. Biochim Biophys Acta. 1976 Mar 12;423(3):431-9. In this category were the actions of rotenone on oxidase, antimycin A on cytochrome c reductase and, in M6 and Z-1, on N,N,N'N'-tetramethyl-p-phenylenediamine oxidase. These results suggest that the respiratory chain of the parental strain branches at the -cytochrome b region into two pathways, each branch goes to a distinct terminal oxidase, and either may be blocked independently by genetic mutation. |
1(0,0,0,1) | Details |
| 4346389 | Wikstrom MK, Berden JA: Oxidoreduction of cytochrome b in the presence of antimycin. Biochim Biophys Acta. 1972 Dec 14;283(3):403-20. |
1(0,0,0,1) | Details |
| 40546 | Lorusso M, Capuano F, Boffoli D, Stefanelli R, Papa S: The mechanism of transmembrane delta muH+ generation in mitochondria by cytochrome c oxidase. Biochem J. 1979 Jul 15;182(1):133-47. In rat liver mitochondria treated with rotenone, N-ethylmaleimide or oligomycin the expected alkalinization caused by consumption for aerobic oxidation of ferrocyanide was delayed with respect to ferrocyanide oxidation, unless carbonyl p-trifluoromethoxyphenylhydrazone was present. 2. This shows that the ferricyanide formed accepts electrons passing through the protonmotive segments of the respiratory chain at the level of cytochrome c and/or redox components of the cytochrome b-c1 complex situated on the side of the antimycin-inhibition site. |
1(0,0,0,1) | Details |
| 8512585 | Lund BO, Miller DM, Woods JS: Studies on Hg (II)-induced H2O2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondria. Biochem Pharmacol. 1993 May 25;45(10):2017-24. This effect was accompanied by significantly increased H2O2 formation, GSH depletion and TBARS formation linked to both NADH dehydrogenase (rotenone-inhibited) and -cytochrome b (antimycin-inhibited) regions of the electron transport chain. |
82(1,1,1,2) | Details |
| 4356125 | Barnes R, Colleran EM, Jones OT: The electron-transport system of mitochondria from the slime mould Physarum polycephalum. Biochem J. 1973 Jul;134(3):745-51. P. polycephalum mitochondria oxidized added via a rotenone-insensitive pathway, but the oxidation of plus was rotenone sensitive; both of these substrates reduced much less cytochrome b than did in both aerobic and anaerobic steady states. |
81(1,1,1,1) | Details |
| 5133534 | Wikstrom MK: Properties of three cytochrome b-like species in mitochondria and submitochondrial particles. Biochim Biophys Acta. 1971 Dec 7;253(2):332-45. |
1(0,0,0,1) | Details |
| 6263247 | Turrens JF, Boveris A: Generation of by the NADH dehydrogenase of bovine heart mitochondria. Biochem J. 1980 Nov 1;191(2):421-7. In - and antimycin-supplemented submitochondrial particles, rotenone has a biphasic effect: it increases O2- production at the NADH dehydrogenase and it inhibits O2- production at the -cytochrome b site. |
32(0,1,1,2) | Details |
| 4345350 | Barnes R, Connelly JL, Jones OT: The utilization of iron and its complexes by mammalian mitochondria. . Biochem J. 1972 Aug;128(5):1043-55. The addition of FeCl (3) to anaerobic particles caused an oxidation of cytochrome b when this region of the respiratory chain was isolated by treatment with rotenone and antimycin A. |
31(0,1,1,1) | Details |
| 1592119 | Aldunate J, Coloma-Torres L, Spencer P, Morello A, Ojeda JM, Repetto Y: Effects of 2 (3)-tert-butyl-4-hydroxyanisole (BHA) on in situ mitochondria of Trypanosoma cruzi. FEBS Lett. 1992 May 25;303(1):73-6. Rotenone did not inhibit the uptake of the parasite. Studies with in situ mitochondria confirmed that BHA, an antioxidant food additive, blocks the mitochondrial electron transport chain at the -cytochrome b segment being the molecular basis of this trypanocidal action. |
1(0,0,0,1) | Details |
| 8392019 | Sohal RS: Aging, cytochrome oxidase activity, and peroxide release by mitochondria. Free Radic Biol Med. 1993 Jun;14(6):583-8. Results are interpreted to suggest that partial inhibition of cytochrome c oxidase activity can lead to the stimulation of mitochondrial H2O2 production in the housefly at site (s) other than NADH dehydrogenase and /cytochrome b region; a possible source may be glycerophosphate dehydrogenase. H2O2 release by mitochondria, inhibited with rotenone and antimycin A, was greatly increased upon supplementation with however, the further addition of KCN or myxothiazol, to such preparations, caused a depression of H2O2 generation. |
1(0,0,0,1) | Details |
| 185865 | Muller W, Schewe T: [The systemic fungicide tridermorph as an inhibitor of the respiratory chain of electron transfer particles from beef heart mitochondria]. Acta Biol Med Ger. 1976;35(6):693-707. The inhibition of the - oxydoreductase activity as well as the suppression of the -induced reduction of all cytochromes on the one hand and the insensitivity of the -ferricyanide oxydoreductase system on the other argue in favour of a site of action similar to rotenone. The partial suppression of the -induced reduction of cytochrome b with simultaneous complete inhibition of the reduction of the other cytochromes indicate an additional site of action analogous to antimycin A. |
1(0,0,0,1) | Details |
| 9396723 | Guidarelli A, Clementi E, Brambilla L, Cantoni O: Mechanism of the antimycin A-mediated enhancement of t-butylhydroperoxide-induced single-strand breakage in DNA. Biochem J. 1997 Dec 15;328 ( Pt 3):801-6. The hypothesis that these effects are selectively linked to inhibition of the electron transport from cytochrome b to cytochrome c1 is validated by the following observations: (1) two complex III inhibitors, antimycin A and 2-heptyl-4-hydroxyquinoline N-oxide, enhanced the tB-OOH-induced DNA cleavage over the same concentration range as that in which inhibition of consumption was observed; (2) the complex III inhibitor-mediated enhancement of tB-OOH-induced DNA damage was abolished by the complex I inhibitor rotenone or by omission, and (3) the enhancing effects of antimycin A were not observed in respiration-deficient cells. |
0(0,0,0,0) | Details |
| 7775420 | Gonzalez-Flecha B, Demple B: Metabolic sources of peroxide in aerobically growing Escherichia coli. J Biol Chem. 1995 Jun 9;270(23):13681-7. Compounds that block electron transport at NADH dehydrogenase (rotenone) or between and cytochrome b (antimycin) showed that univalent reduction of O2 can occur at these sites in vivo to form (O2-), in agreement with reports for mammalian mitochondria. |
31(0,1,1,1) | Details |
| 5160697 | Nelson BD, Norling B, Persson B, Ernster L: Effect of thenoyltrifluoroacetone on the interaction of succinate dehydrogenase and cytochrome b in -depleted submitochondrial particles. Biochem Biophys Res Commun. 1971 Sep 17;44(6):1312-20. |
1(0,0,0,1) | Details |
| 8268305 | Kolesova GM, Karnaukhova LV, Segal' NK, Iaguzhinskii LS: [The effect of inhibitors of the Q-cycle on cyano-resistant oxidation of by rat liver mitochondria in the presence of Biokhimiia. 1993 Oct;58(10):1630-40. In the presence of myxothiazole and antimycin oxidizes cytochrome b. In the presence of rotenone, when is reduced by DT-diaphorase, the rate of cyano-resistant respiration decreases approximately twofold; its sensitivity towards myxothiazole and antimycin drops down to 40%. |
1(0,0,0,1) | Details |
| 647077 | Totpvets ZP: [Oxidation of 4-N--5-methoxy-1,2-dioxybenzene via the mitochondrial respiratory chain]. Biokhimiia. 1978 Feb;43(2):260-7. The site of AMOBQH2 interaction is located in the region of cytochrome b, between rotenone and antimycin block. |
31(0,1,1,1) | Details |
| 207670 | Kenimer EA, Lapp DF: Effects of selected inhibitors on electron transport in Neisseria gonorrhoeae. J Bacteriol. 1978 May;134(2):537-45. The effects of selected electron transport inhibitors (amytal, rotenone, 2-heptyl-4-hydroxyquinoline, antimycin A1, and [KCN]) on electron transfer in whole-cell and sonically treated whole-cell preparations of N. gonorrhoeae were examined. Difference spectra in the presence of 2-heptyl-4-hydroxyquinoline suggest a possible site of interaction of this compound at the substrate side of cytochrome b. |
1(0,0,0,1) | Details |
| 8216312 | Debise R, Touraille S, Durand R, Alziari S: Biochemical consequences of a large deletion in the mitochondrial genome of a Drosophila subobscura strain. Biochem Biophys Res Commun. 1993 Oct 15;196(1):355-62. Spectrophotometric determination of respiratory complex activities shows that: complex I (5 genes implicated in deletion) presents maximal activity reduced by 40%, whereas that of complex III (concerned by cytochrome b) is lowered by 30%. |
1(0,0,0,1) | Details |
| 893348 | Harris MA, Reddy CA: Hydrogenase activity and the H2- electron transport system in Bacteroides fragilis. J Bacteriol. 1977 Sep;131(3):922-8. Inhibition of reduction by acriflavin, rotenone, 2-heptyl-4-hydroxyquinoline-N-oxide, and antimycin A suggest the involvement of a flavoprotein, a and cytochrome b in the reduction of to |
31(0,1,1,1) | Details |
| 7358642 | Ito A: Cytochrome b5-like hemoprotein of outer mitochondrial membrane: OM cytochrome b. J Biochem. 1980 Jan;87(1):73-80. Contribution of OM cytochrome b to rotenone-insensitive -cytochrome c reductase activity.. |
16(0,0,2,6) | Details |
| 10844979 | Obungu VH, Kiaira JK, Olembo NK, Njogu MR: Pathways of catabolism in procyclic Trypanosoma congolense. Indian J Biochem Biophys. 1999 Oct;36(5):305-11. Studies of respiration on in procyclic Trypanosoma congolense in the presence of rotenone, antimycin, salicylhydroxamic acid and have indicated the presence of NADH dehydrogenase, cytochrome b-c1, cytochrome aa3, trypanosome alternate oxidase and reductase/succinate dehydrogenase pathway that contributes electrons to of the respiratory chain. |
6(0,0,1,1) | Details |
| 210759 | Halestrap AP: Stimulation of the respiratory chain of rat liver mitochondria between cytochrome c1 and cytochrome c by glucagon treatment of rats. Biochem J. 1978 Jun 15;172(3):399-405. Measurement of the cytochrome spectra under uncoupled conditions in the presence of and rotenone demonstrates a crossover between cytochromes c and c (1) when control mitochondria are compared with those from glucagon-treated rats, cytochrome c being more oxidized and cytochrome c (1) more reduced in control mitochondria. Under conditions where pyruvate metabolism is studied the control mitochondria are generally more oxidized than those from glucagon-treated rats, the redox state of cytochrome b-566 correlating with the rate of pyruvate metabolism in medium. |
3(0,0,0,3) | Details |
| 168827 | Schwartz AC, Sporkenbach J: The electron transport system of the anaerobic Propionibacterium shermanii: cytochrome and inhibitor studies. Arch Microbiol. 1975 Mar 10;102(3):261-73. Cytochrome b was reduced by to about 50%, and by lactate or to 80--90%. 3. The inhibitory effects of amytal and rotenone on oxidation, but not on the oxidation of the other substrates, indicated the presence of the NADH dehydrogenase complex, or "site I region", in the electron transport system of P. shermanii. 4. |
3(0,0,0,3) | Details |
| 1751550 | Gregory RB, Berry MN: On the thyroid hormone-induced increase in respiratory capacity of isolated rat hepatocytes. Biochim Biophys Acta. 1991 Dec 3;1098(1):61-7. However, less rotenone was required for maximal inhibition of respiration in the hypothyroid state than in cells from euthyroid or hyperthyroid rats, implying that hepatocytes from hypothyroid animals contain less NADH dehydrogenase. |
0(0,0,0,0) | Details |
| 2321971 | Bolter CJ, Chefurka W: Extramitochondrial release of peroxide from insect and mouse liver mitochondria using the respiratory inhibitors phosphine, myxothiazol, and antimycin and spectral analysis of inhibited cytochromes. Arch Biochem Biophys. 1990 Apr;278(1):65-72. Other respiratory inhibitors, antimycin, myxothiazol, and rotenone were used with insect mitochondria. |
0(0,0,0,0) | Details |
| 1171697 | Wang CC: Studies of the mitochondria from Eimeria tenella and inhibition of the electron transport by quinolone coccidiostats. Biochim Biophys Acta. 1975 Aug 11;396(2):210-9. The mitochondrial respiration was inhibited by azide, antimycin A, and 2-heptyl-4-hydroxyquinoline-N-oxide, but was relatively resistant to rotenone and amytal. |
0(0,0,0,0) | Details |
| 4323963 | Wong DT, Horng JS, Gordee RS: Respiratory chain of a pathogenic fungus, Microsporum gypseum: effect of the antifungal agent pyrrolnitrin. J Bacteriol. 1971 Apr;106(1):168-73. In mitochondrial preparations, pyrrolnitrin strongly inhibited respiration and the rotenone-sensitive -cytochrome c reductase. The extent of reduction of flavoproteins by and measured at 465 - 510 nm, was unaltered; however, the reduction of cytochrome b, measured at 560 - 575 nm, was partially inhibited by pyrrolnitrin. |
3(0,0,0,3) | Details |
| 7150580 | Hatefi Y, Yagi T: Kinetics of cytochrome b oxidation in antimycin-treated submitochondrial particles. Biochemistry. 1982 Dec 7;21(25):6614-8. By contrast, rotenone, BAL (2,3-dimercaptopropanol), and 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole [Trumpower, B. |
2(0,0,0,2) | Details |
| 9824492 | Carrasco-Marin E, Paz-Miguel JE, Lopez-Mato P, Alvarez-Dominguez C, Leyva-Cobian F: Oxidation of defined antigens allows protein unfolding and increases both proteolytic processing and exposes peptide epitopes which are recognized by specific T cells. Immunology. 1998 Nov;95(3):314-21. However, neither rotenone and antimycins (inhibitors of O-2 production at the NADH dehydrogenase and -cytochrome b regions, respectively) nor aminoguanidine (an inducible synthase inhibitor) impaired antigen presentation, thus indirectly discarding the participation of mitochondrial oxidation and reactive intermediates (RNI) in antigen processing. |
0(0,0,0,0) | Details |
| 6513990 | Takamiya S, Furushima R, Oya H: Electron transfer complexes of Ascaris suum muscle mitochondria: I. Mol Biochem Parasitol. 1984 Oct;13(2):121-34. The enzyme preparation catalyzed the reduction of 1.68 mumol cytochrome c min-1 mg-1 protein at 25 degrees C with but not with and retained its sensitivity to rotenone, piericidin A and 2-heptyl-4-hydroxyquinoline-N-oxide as with the submitochondrial particles. |
0(0,0,0,0) | Details |
| 7199109 | Il'chenko AP, Komarova GN: oxidation by the mitochondria of Torulopsis candida] . Mikrobiologiia. 1981 Nov-Dec;50(6):964-72. When is oxidized in aerobic conditions, cytochrome b is reduced, with the absorption maxima in alpha, beta and gamma bands being at 555, 526 and 425 nm, respectively. The cytochrome is reduced in aerobic conditions also in the presence of exogenous and rotenone. |
2(0,0,0,2) | Details |
| 6093033 | Papadimitriou A, Neustein HB, Dimauro S, Stanton R, Bresolin N: Histiocytoid cardiomyopathy of infancy: deficiency of reducible cytochrome b in heart mitochondria. Pediatr Res. 1984 Oct;18(10):1023-8. Biochemical studies showed markedly decreased -cytochrome c reductase and rotenone-sensitive -cytochrome c reductase activities, while other mitochondrial enzymes were normal. |
2(0,0,0,2) | Details |
| 147472 | Streumer-Svobodova Z, Drahota Z: The development of oxidative enzymes in rat liver mitochondria. . Physiol Bohemoslov. 1977;26(6):525-34. Rotenone-insensitive -cytochrome c reductase activity, which is localized on the outer mitochondrial membrane, remained stable up to the 10th day, and rose between the 10th and the 90th day. |
0(0,0,0,0) | Details |
| 16934215 | Gonzalez B, Martinez S, Chavez JL, Lee S, Castro NA, Dominguez MA, Gomez S, Contreras ML, Kennedy C, Escamilla JE: Respiratory system of Gluconacetobacter diazotrophicus PAL5. Biochim Biophys Acta. 2006 Dec;1757(12):1614-22. Epub 2006 Jul 8. Strong inhibition by rotenone and and resistance to indicated that -quinone oxidoreductase is a NDH-1 type enzyme. |
0(0,0,0,0) | Details |
| 9813002 | Vercesi AE, Rodrigues CO, Uyemura SA, Zhong L, Moreno SN: Respiration and oxidative phosphorylation in the apicomplexan parasite Toxoplasma gondii. J Biol Chem. 1998 Nov 20;273(47):31040-7. Although ADP phosphorylation was detected in the presence of this activity was rotenone-insensitive and was probably due to the conversion of into through a reductase activity that was detected in mitochondrial extracts. Atovaquone was shown to inhibit the respiratory chain of T. gondii and mammalian mitochondria between cytochrome b and c1 as occurs with antimycin A1. |
1(0,0,0,1) | Details |
| 4358869 | Wikstrom MK: The different cytochrome b components in the respiratory chain of animal mitochondria and their role in electron transport and energy conservation. Biochim Biophys Acta. 1973 Dec 7;301(2):155-93. |
1(0,0,0,1) | Details |
| 9395404 | Hasegawa E, Kang D, Sakamoto K, Mitsumoto A, Nagano T, Minakami S, Takeshige K: A dual effect of 1-methyl-4-phenylpyridinium (MPP+)-analogs on the respiratory chain of bovine heart mitochondria. Arch Biochem Biophys. 1997 Jan 1;337(1):69-74. We examined effects of several compounds, structurally related to 1-methyl-4-phenylpyridinium (MPP+), on the -dependent respiration of bovine heart submitochondrial particles. 1-Methyl-4-(3 '-trimethylammoniophenyl) pyridinium (analog 8) as well as MPP+ completely inhibited O2 consumption, reduction of and reduction of cytochrome b in a dose-dependent manner. The production of (O2-) induced by MPP+ or analog 8 was to the same extent as that by rotenone, an inhibitor of complex I of the mitochondrial respiratory chain. |
1(0,0,0,1) | Details |
| 9241135 | Hasegawa E, Kang D, Sakamoto K, Mitsumoto A, Nagano T, Minakami S, Takeshige K: A Dual Effect of 1-Methyl-4-phenylpyridinium (MPP+ )-Analogs on the Respiratory Chain of Bovine Heart Mitochondria. Arch Biochem Biophys. 1997 Jan 1;337(1):69-74. We examined effects of several compounds, structurally related to 1-methyl-4-phenylpyridinium (MPP+ ), on the -dependent respiration of bovine heart submitochondrial particles. 1-Methyl-4-(3'-trimethylammoniophenyl) pyridinium (analog 8) as well as MPP+ completely inhibited O2 consumption, reduction of and reduction of cytochrome b in a dose-dependent manner. The production of (O- 2 ) induced by MPP+ or analog 8 was to the same extent as that by rotenone, an inhibitor of complex I of the mitochondrial respiratory chain. |
1(0,0,0,1) | Details |
| 15479985 | Ichikawa H, Kokura S, Aw TY: Role of endothelial mitochondria in oxidant production and modulation of neutrophil adherence. J Vasc Res. 2004 Sep-Oct;41(5):432-44. Epub 2004 Oct 12. The current objectives were to (1) determine the adhesion of human neutrophils to human umbilical vein endothelial cells exposed to antimycin A, a specific inhibitor of the mitochondrial cytochrome b-c (1) complex, and (2) define the mechanisms responsible for the early and late phases of neutrophil hyperadhesivity. Blockade of electron transport in antimycin A and A/R exposed cells with rotenone, amytal or thenoyltrifluoroacetate, but not myxothiazol, prevented neutrophil adhesion, confirming a role for mitochondrial ROS. |
1(0,0,0,1) | Details |
| 4749271 | Boveris A, Chance B: The mitochondrial generation of peroxide. Biochem J. 1973 Jul;134(3):707-16. It is postulated that in addition to the well-known flavin reaction, formation of H (2) O (2) may be due to interaction with an energy-dependent component of the respiratory chain at the cytochrome b level. With - H (2) O (2) formation is sensitive to rotenone. |
1(0,0,0,1) | Details |
| 2919886 | Cino M, Del Maestro RF: Generation of peroxide by brain mitochondria: the effect of reoxygenation following postdecapitative ischemia. Arch Biochem Biophys. 1989 Mar;269(2):623-38. -supported H2O2 generation was diminished by rotenone and the uncoupler carbonyl m-chlorphenylhydrazone and enhanced by antimycin A and increased tensions. When maximally reduced, the NADH dehydrogenase and the -cytochrome b regions of the electron transport chain are sources of H2O2. |
1(0,0,0,1) | Details |
| 6289887 | Bindoli A, Cavallini L, Jocelyn P: Mitochondrial lipid peroxidation by cumene hydroperoxide and its prevention by Biochim Biophys Acta. 1982 Sep 15;681(3):496-503. The results suggest that reduction of mitochondrial may prevent the generation of lipid hydroperoxides but that their subsequent removal may require reduction at or beyond cytochrome b. Conversely, rotenone and N-ethylmaleimide stimulate the reaction. |
1(0,0,0,1) | Details |
| 5422599 | Slater EC, Lee CP, Berden JA, Wegdam HJ: High-energy forms of cytochrome b. Nature. 1970 Jun 27;226(5252):1248-9. |
1(0,0,0,1) | Details |
| 1567448 | Unnikrishnan LS, Raj RK: reductase system of filarial parasite Setaria digitata. Biochem Biophys Res Commun. 1992 Apr 15;184(1):448-53. This activity is sensitive to rotenone, antimycin A and o- diphenyl. The reductase system consisting of NADH-coenzyme Q reductase, cytochrome b like component (s) and succinate dehydrogenase/ reductase is thus very important and hence specific inhibitors of the system may prove useful in the effective control of filariasis. |
1(0,0,0,1) | Details |
| 2871147 | Sugiyama Y, Fujita T, Matsumoto M, Okamoto K, Imada I: Effects of idebenone (CV-2619) and its metabolites on respiratory activity and lipid peroxidation in brain mitochondria from rats and dogs. J Pharmacobiodyn. 1985 Dec;8(12):1006-17. These facts and results of inhibitor analysis suggest that the action site of CV-2619 is -linked complex I in the mitochondrial respiratory chain and is different from that of inhibitors of oxidative phosphorylation such as rotenone, oligomycin and 2,4-dinitrophenol. Reduced CV-2619 (2H-CV-2619) was rapidly oxidized through the cytochrome b chain, indicating that the compound functioned simply as an electron carrier of mitochondrial respiratory system. |
1(0,0,0,1) | Details |
| 5074740 | Pedersen JI, Flatmark T: Studies on the energy state of isolated brown adipose tissue mitochondria. Biochim Biophys Acta. 1972 Aug 17;275(2):135-47. The cytochrome b complex as a probe of the energy state of the mitochondrial inner membrane. |
1(0,0,0,1) | Details |