Protein Information

Name sodium channel (protein family or complex)
Synonyms Sodium channel

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
17173871 Molchanova SM, Oja SS, Saransaari P: Inhibitory effect of taurine on veratridine-evoked D-[3H] aspartate release from murine corticostriatal slices: involvement of chloride channels and mitochondria. Brain Res. 2007 Jan 26;1130(1):95-102. Epub 2006 Dec 14.

The respiratory chain blocker rotenone or mitochondrial protonophore carbonyl cyanide 3-chlorophenylhydrazone (CCCP) in combination with the mitochondrial ATPase inhibitor oligomycin, which inhibits the mitochondrial Ca2+ uniporter, also reduced the effect of taurine.
We have previously shown that the inhibitory neuromodulator taurine attenuates the release of preloaded D-[3H] aspartate from murine corticostriatal slices evoked by ischemic conditions or by application of the sodium channel agonist veratridine.
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14505934 Deng Y, Nicholson RA: Stimulation by surangin B of endogenous amino acid release from synaptosomes. Toxicon. 2003 Sep 15;42(4):351-7.

In all cases, these responses were reduced by removing calcium from the saline and surangin B-evoked release of GLU, GABA, aspartic acid (ASP) and alanine was significantly inhibited by the sodium channel blocker tetrodotoxin.
Rotenone (a complex I inhibitor) and carbonyl cyanide chlorophenylhydrazone (CCCP; an uncoupler), were more potent releasers of amino acids from synaptosomes than surangin B, however, carboxin (a complex II-selective inhibitor), was extremely weak to ineffective in this regard.
1(0,0,0,1) Details