| Name | ubiquitin |
|---|---|
| Synonyms | HMG20; RPS27A; UBA80; UBCEP 1; UBCEP1; UBA52; UBCEP 2; UBCEP2… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11100151 | Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT: Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci. 2000 Dec;3(12):1301-6. Nigral neurons in rotenone-treated rats accumulate fibrillar cytoplasmic inclusions that contain ubiquitin and alpha-synuclein. |
6(0,0,1,1) | Details |
| 19681169 | Tapias V, Cannon JR, Greenamyre JT: treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model. J Neurosci Res. 2010 Feb 1;88(2):420-7. The rat rotenone model reproduces many of the pathological features of the human disease, including apomorphine-responsive behavioral deficits, DA depletion, loss of striatal DA terminals and nigral dopaminergic neurons, and alpha-synuclein/polyubiquitin-positive cytoplasmic inclusions reminiscent of Lewy bodies. |
6(0,0,1,1) | Details |
| 18624765 | Zhang H, Jia H, Liu J, Ao N, Yan B, Shen W, Wang X, Li X, Luo C, Liu J: Combined R- and exerts efficient preventative effects in a cellular model of Parkinson's disease. J Cell Mol Med. 2008 Jun 20. We demonstrated that 4-week pretreatment with LA and/or ALC effectively protected SK-N-MC human neuroblastoma cells against rotenone-induced mitochondrial dysfunction, oxidative damage, and accumulation of alpha-synuclein and ubiquitin. |
6(0,0,1,1) | Details |
| 19385059 | Cannon JR, Tapias V, Na HM, Honick AS, Drolet RE, Greenamyre JT: A highly reproducible rotenone model of Parkinson's disease. Neurobiol Dis. 2009 May;34(2):279-90. Additionally, in rotenone-treated animals, alpha-synuclein and poly-ubiquitin positive aggregates were observed in neurons of the substantia nigra. |
6(0,0,1,1) | Details |
| 15252205 | Yao D, Gu Z, Nakamura T, Shi ZQ, Ma Y, Gaston B, Palmer LA, Rockenstein EM, Zhang Z, Masliah E, Uehara T, Lipton SA: Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10810-4. Epub 2004 Jul 13. |
3(0,0,0,3) | Details |
| 18178165 | Tsuruta T, Oh-hashi K, Kiuchi K, Hirata Y: Degradation of caspase-activated DNase by the ubiquitin-proteasome system. Biochim Biophys Acta. 2008 May;1780(5):793-9. Epub 2007 Dec 15. |
3(0,0,0,3) | Details |
| 17686240 | Wang L, Cao XB, Wang JM, Qu RS, Xu L, Qiao X, Sun SG: [Proteolytic stress induced by environmental toxins in dopaminergic neurons: an experimental study]. Zhonghua Yi Xue Za Zhi. 2007 May 8;87(17):1190-4. METHODS: Nerve growth factor-treated-rat adrenal pheochromocytoma cells of the line PC12 were co-incubated with (6-OHDA), 1-methyl-4-phenylpyridinium ion (MPP (+)), and rotenone for 24 hours. Immunofluorescence double labeling confirmed the overexpression of alpha-synuclein and ubiquitin and pellet accumulation in the cytoplasm induced by three toxins. |
2(0,0,0,2) | Details |
| 17565155 | Oh SH, Woo JK, Yazici YD, Myers JN, Kim WY, Jin Q, Hong SS, Park HJ, Suh YG, Kim KW, Hong WK, Lee HY: Structural basis for depletion of heat shock protein 90 client proteins by deguelin. J Natl Cancer Inst. 2007 Jun 20;99(12):949-61. Epub 2007 Jun 12. The proteasome inhibitor MG132 was used to investigate deguelin's effect on the induction of ubiquitin-mediated proteasomal degradation of HIF-1alpha. |
2(0,0,0,2) | Details |
| 16258387 | Rambhia S, Mantione KJ, Stefano GB, Cadet P: Morphine modulation of the ubiquitin-proteasome complex is neuroprotective. Med Sci Monit. 2005 Nov;11(11):BR386-96. Rotenone, which induces oxidative stress and increases the expression of the proteasomal catalytic X subunit, causes the cells to die and morphine inhibits this process via NO. |
2(0,0,0,2) | Details |
| 18715146 | Ethell DW, Fei Q: Parkinson-linked genes and toxins that affect neuronal cell death through the Bcl-2 family. Antioxid Redox Signal. 2009 Mar;11(3):529-40. Oxidative stress induced by the neurotoxins MPTP, paraquat, maneb, and rotenone causes lipid peroxidation and protein misfolding that affects cell death through members of the Bcl-2 family. Of the familial mutations identified thus far, two of the loci encode proteins associated with ubiquitin-proteasome degradation of misfolded proteins (Parkin and Uch-L1), and two encode proteins associated with mitochondria and oxidative stress (DJ-1 and PINK1). |
2(0,0,0,2) | Details |
| 11535288 | Shastry BS: Parkinson disease: etiology, pathogenesis and future of gene therapy. Neurosci Res. 2001 Sep;41(1):5-12. Two of these genes are involved in the ubiquitin mediated pathway of protein degradation and the third one is a highly expressed protein in the synaptic terminal and is called alpha-synuclein. In animal models, it has been shown that use of the household pesticide which is known to contain rotenone, causes PD. |
1(0,0,0,1) | Details |
| 17101781 | Pan Y, Mansfield KD, Bertozzi CC, Rudenko V, Chan DA, Giaccia AJ, Simon MC: Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. Mol Cell Biol. 2007 Feb;27(3):912-25. Epub 2006 Nov 13. Prolyl hydroxylation of hypoxible-inducible factor alpha (HIF-alpha) proteins is essential for their recognition by pVHL containing ubiquitin ligase complexes and subsequent degradation in (O (2))-replete cells. Furthermore, cells treated with mitochondrial inhibitors, such as rotenone and myxothiazol, provided direct evidence that PHDs remain active in hypoxic cells lacking functional mitochondria. |
1(0,0,0,1) | Details |
| 12588799 | Darios F, Corti O, Lucking CB, Hampe C, Muriel MP, Abbas N, Gu WJ, Hirsch EC, Rooney T, Ruberg M, Brice A: Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death. Hum Mol Genet. 2003 Mar 1;12(5):517-26. In this cell line, neuronally differentiated by nerve growth factor, Parkin overproduction protected against cell death mediated by but not by a variety of other cell death inducers (H (2) O (2), rotenone, 6-OHDA, tunicamycin, 2-mercaptoethanol and staurosporine). Protection was abrogated by the proteasome inhibitor epoxomicin and disease-causing variants, indicating that it was mediated by the E3 ubiquitin ligase activity of Parkin. |
1(0,0,0,1) | Details |
| 16517603 | Rosen KM, Veereshwarayya V, Moussa CE, Fu Q, Goldberg MS, Schlossmacher MG, Shen J, Querfurth HW: Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells. J Biol Chem. 2006 May 5;281(18):12809-16. Epub 2006 Mar 3. Mutations in the ubiquitin ligase-encoding Parkin gene have been implicated in the pathogenesis of autosomal recessive Parkinson disease. In comparing primary cultures of skeletal muscle derived from parkin knock-out and wild-type mice, we have found the absence of parkin to result in greater sensitivity to mitochondrial stressors rotenone and carbonyl 3-chlorophenylhydrazone, without any alteration in sensitivity to ionophore or peroxide. |
1(0,0,0,1) | Details |
| 20171192 | Um JW, Park HJ, Song J, Jeon I, Lee G, Lee PH, Chung KC: Formation of parkin aggregates and enhanced PINK1 accumulation during the pathogenesis of Parkinson's disease. Biochem Biophys Res Commun. 2010 Mar 19;393(4):824-8. Epub 2010 Feb 18. We have recently shown that parkin (an E3 ubiquitin ligase) and PINK1 (a serine/threonine kinase) affect one other's stability, solubility, and tendency to form cytoprotective aggresomes (Um et al., 2009). Consistent with our previous findings from parkin knockout mice, rat models of PD -, rotenone-, or MG132-induced PD) were also associated with an increase in soluble and insoluble PINK1 levels as well as enhanced formation of parkin aggregates. |
1(0,0,0,1) | Details |
| 15198987 | Jiang H, Ren Y, Zhao J, Feng J: Parkin protects human dopaminergic neuroblastoma cells against -induced apoptosis. Hum Mol Genet. 2004 Aug 15;13(16):1745-54. Epub 2004 Jun 15. Among the five PD-linked genes identified so far, parkin, a protein-ubiquitin E3 ligase, appears to be the most prevalent genetic factor in PD. Here, we show that overexpression of parkin protected human DA neuroblastoma cell line (SH-SY5Y) against apoptosis induced by DA or 6-OHDA, but not by H (2) O (2) or rotenone. |
1(0,0,0,1) | Details |
| 16219024 | Hoglinger GU, Lannuzel A, Khondiker ME, Michel PP, Duyckaerts C, Feger J, Champy P, Prigent A, Medja F, Lombes A, Oertel WH, Ruberg M, Hirsch EC: The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy. J Neurochem. 2005 Nov;95(4):930-9. Epub 2005 Aug 10. Many tau+ cell bodies also stained positive for thioflavin S, nitrotyrosine and ubiquitin. |
1(0,0,0,1) | Details |
| 16584840 | Lev N, Melamed E, Offen D: Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage. Neurosci Lett. 2006 May 15;399(1-2):27-32. Epub 2006 Apr 11. Naive and transfected cells were exposed to oxidative stress induced by rotenone, SIN-I, FeCl (2,) and to proteasomal inhibition by lactacystin. Proteasomal inhibition caused a dose-dependent decrease in viability and induced protein aggregates formation containing alpha-synuclein and ubiquitin. |
1(0,0,0,1) | Details |
| 11724769 | Lee HJ, Shin SY, Choi C, Lee YH, Lee SJ: Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors. J Biol Chem. 2002 Feb 15;277(7):5411-7. Epub 2001 Nov 27. Treatment with rotenone, an inhibitor of complex I, resulted in an increase of detergent-resistant alpha-synuclein aggregates and a reduction in ATP level. The inclusions were co-stained with ubiquitin, 20 S proteasome, gamma-tubulin, and vimentin. |
1(0,0,0,1) | Details |
| 19682553 | Pan T, Rawal P, Wu Y, Xie W, Jankovic J, Le W: Rapamycin protects against rotenone-induced apoptosis through autophagy induction. Neuroscience. 2009 Dec 1;164(2):541-51. Epub 2009 Aug 12. Ubiquitin proteasome system (UPS) and autophagy lysosome pathway (ALP) are the two most important routes for degradation of aggregated/misfolded proteins. |
1(0,0,0,1) | Details |
| 18840762 | Eley HL, Russell ST, Tisdale MJ: Mechanism of attenuation of muscle protein degradation induced by tumor necrosis factor-alpha and angiotensin II by Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1417-26. Epub 2008 Oct 7. Increased ROS formation is known to induce protein degradation through the ubiquitin-proteasome pathway. Formation of ROS was attenuated by rotenone, an inhibitor of the mitochondrial electron transport chain, nitro- methyl ester, an inhibitor of synthase, and SB 203580, a specific inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), which also attenuated total protein degradation. |
1(0,0,0,1) | Details |
| 12716939 | Ren Y, Zhao J, Feng J: Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation. J Neurosci. 2003 Apr 15;23(8):3316-24. In addition to inhibiting the mitochondrial respiratory chain, toxins known to cause Parkinson's disease (PD), such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and rotenone, also strongly depolymerize microtubules and increase tubulin degradation. Here we report that parkin, a protein-ubiquitin E3 ligase linked to PD, was tightly bound to microtubules in taxol-mediated microtubule coassembly assays. |
1(0,0,0,1) | Details |
| 12531233 | Orr CF, Rowe DB, Halliday GM: An inflammatory review of Parkinson's disease. Prog Neurobiol. 2002 Dec;68(5):325-40. The mutant gene products all cause dysfunction of the ubiquitin-proteosome system, identifying protein modification and degradation as critical for pathogenesis. |
1(0,0,0,1) | Details |
| 19781773 | Ito S, Oyake T, Murai K, Ishida Y: Deguelin suppresses cell proliferation via the inhibition of survivin expression and STAT3 phosphorylation in HTLV-1-transformed T cells. Leuk Res. 2010 Mar;34(3):352-7. Epub 2009 Sep 24. Furthermore, proteasome inhibitor MG132 prevented the down-regulation of survivin expression and STAT3 dephosphorylation by deguelin, suggesting that the action mechanism of deguelin involves the degradation of survivin and phosphorylated STAT3 through the ubiquitin/proteasome pathway. |
1(0,0,0,1) | Details |
| 17079513 | Feng J: Microtubule: a common target for parkin and Parkinson's disease toxins. Neuroscientist. 2006 Dec;12(6):469-76. Depolymerization of microtubules by PD toxins such as rotenone disrupts vesicular transport. On the other hand, parkin, one of the most frequently mutated genes in PD, encodes for a protein-ubiquitin E3 ligase that strongly binds to microtubules. |
1(0,0,0,1) | Details |
| 16626962 | Wang XF, Li S, Chou AP, Bronstein JM: Inhibitory effects of pesticides on proteasome activity: implication in Parkinson's disease. Neurobiol Dis. 2006 Jul;23(1):198-205. Epub 2006 Apr 19. Epidemiological studies have suggested a correlation of pesticides and Parkinson's disease (PD) while genetic and biochemical studies have implicated the ubiquitin-proteasome system (UPS) in the pathogenesis of PD. Six out of 25 representative pesticides, including rotenone, ziram, diethyldithiocarbamate, endosulfan, benomyl, and dieldrin, showed inhibitory effects on proteasome activities at low concentrations (10 nM to 10 microM). |
1(0,0,0,1) | Details |
| 19924695 | McNaught KS, Jnobaptiste R, Jackson T, Jengelley TA: The pattern of neuronal loss and survival may reflect differential expression of proteasome activators in Parkinson's disease. Synapse. 2010 Mar;64(3):241-50. The basis of neuronal vulnerability, degeneration, and sparing in PD are unknown, but there is increasing evidence to suggest that the ubiquitin-proteasome system (UPS) plays an important role in the pathogenesis of the disorder. |
1(0,0,0,1) | Details |
| 16375772 | Perez FA, Curtis WR, Palmiter RD: Parkin-deficient mice are not more sensitive to or methamphetamine neurotoxicity. BMC Neurosci. 2005 Dec 24;6:71. Nevertheless, Parkin-deficient mice could be more sensitive to other neurotoxins, such as rotenone or MPTP, which have different mechanisms of action; therefore, identifying conditions that precipitate parkinsonism specifically in Parkin-deficient mice would increase the utility of this model and could provide insight into the mechanism of AR-JP. |
0(0,0,0,0) | Details |
| 15890011 | Zeevalk GD, Bernard LP: Energy status, ubiquitin proteasomal function, and oxidative stress during chronic and acute complex I inhibition with rotenone in mesencephalic cultures. Antioxid Redox Signal. 2005 May-Jun;7(5-6):662-72. Findings show that selective cell loss and alterations in ubiquitin proteasomal function only occur with rotenone exposures that partially maintain ATP/ADP. |
149(1,3,4,4) | Details |
| 12177198 | Sherer TB, Betarbet R, Stout AK, Lund S, Baptista M, Panov AV, Cookson MR, Greenamyre JT: An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J Neurosci. 2002 Aug 15;22(16):7006-15. Chronic systemic complex I inhibition caused by rotenone exposure induces features of Parkinson's disease (PD) in rats, including selective nigrostriatal dopaminergic degeneration and formation of ubiquitin- and alpha-synuclein-positive inclusions (Betarbet et al., 2000). |
68(0,2,3,3) | Details |
| 18804145 | Kaneko K, Hineno A, Yoshida K, Ikeda S: Increased vulnerability to rotenone-induced neurotoxicity in ceruloplasmin-deficient mice. Neurosci Lett. 2008 Nov 28;446(1):56-8. Epub 2008 Sep 11. Immunohistochemical examination showed that acrolein, one of the products of lipid peroxides, and ubiquitin were more markedly immunoreacted in the brains of rotenone-treated, Cp-deficient mice than in rotenone-untreated, Cp-deficient or rotenone-treated, wild-type mice. |
37(0,1,2,2) | Details |
| 17587308 | Ren Y, Feng J: Rotenone selectively kills serotonergic neurons through a microtubule-dependent mechanism. J Neurochem. 2007 Oct;103(1):303-11. Epub 2007 Jun 22. Over-expression of parkin, a protein-ubiquitin E3 ligase that strongly binds to microtubules, greatly attenuated the selective toxicity of rotenone or colchicine. |
31(0,1,1,1) | Details |
| 18639366 | Jia H, Liu Z, Li X, Feng Z, Hao J, Li X, Shen W, Zhang H, Liu J: Synergistic anti-Parkinsonism activity of high doses of B vitamins in a chronic cellular model. Neurobiol Aging. 2010 Apr;31(4):636-46. Epub 2008 Jul 17. Pretreatment with B vitamins (also 4 weeks) prevented rotenone-induced: (1) mitochondrial dysfunction, including reduced mitochondrial membrane potential and activities of complex I; (2) oxidative stress, including increase in reactive species, oxidative DNA damage and protein oxidation, and (3) Parkinsonism parameters, including accumulation of alpha-synuclein and poly-ubiquitin. |
31(0,1,1,1) | Details |
| 18586549 | Koch A, Lehmann-Horn K, Dachsel JC, Gasser T, Kahle PJ, Lucking CB: Proteasomal inhibition reduces parkin mRNA in PC12 and SH-SY5Y cells. Parkinsonism Relat Disord. 2009 Mar;15(3):220-5. Epub 2008 Jun 30. We systematically investigated whether PD-related stresses including MG132 and epoxomicin (proteasomal impairment), tunicamycin (unfolded protein stress), and rotenone (mitochondrial dysfunction) resulted in expressional changes of parkin and other E3 ubiquitin ligases (dorfin, SIAH-1). |
7(0,0,1,2) | Details |
| 16439141 | Betarbet R, Canet-Aviles RM, Sherer TB, Mastroberardino PG, McLendon C, Kim JH, Lund S, Na HM, Taylor G, Bence NF, Kopito R, Seo BB, Yagi T, Yagi A, Klinefelter G, Cookson MR, Greenamyre JT: Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system. Neurobiol Dis. 2006 May;22(2):404-20. Epub 2006 Jan 24. |
7(0,0,1,2) | Details |