Protein Information

Name protein tyrosine phosphatase
Synonyms DUSP16; DUSP16 protein; Dual specificity phosphatase 16; Dual specificity protein phosphatase 16; MAP kinase phosphatase 7; MAPK phosphatase 7; MKP 7; MKP7…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
10833515 Sattler M, Verma S, Shrikhande G, Byrne CH, Pride YB, Winkler T, Greenfield EA, Salgia R, Griffin JD: The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells. J Biol Chem. 2000 Aug 11;275(32):24273-8.


Oxidative stress through ROS is believed to have many biochemical effects, including the potential ability to inhibit protein-tyrosine phosphatases (PTPases).
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16287083 Taddei ML, Chiarugi P, Cuevas C, Ramponi G, Raugei G: Oxidation and inactivation of low molecular weight protein tyrosine phosphatase by the anticancer drug Aplidin. Int J Cancer. 2006 Apr 15;118(8):2082-8.

Rotenone, but not other selective inhibitors of ROS production, blocks the induction of ROS, suggesting the involvement of the mitochondrial respiratory chain in Aplidin action.
2(0,0,0,2) Details