Protein Information

Name ornithine aminotransferase
Synonyms HOGA; OAT; OAT protein; OATL 3; OATL3; Ornithine aminotransferase; Ornithine aminotransferase like 3; Ornithine aminotransferase variant…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
849273 McGivan JD, Bradford NM, Beavis AD: Factors influencing the activity of ornithine aminotransferase in isolated rat liver mitochondria. Biochem J. 1977 Jan 15;162(1):147-56.

No ornithine was formed in the absence of rotenone. 3.
3(0,0,0,3) Details
15535970 Haslett MR, Pink D, Walters B, Brosnan ME: Assay and subcellular localization of pyrroline-5-carboxylate dehydrogenase in rat liver. Biochim Biophys Acta. 2004 Nov 18;1675(1-3):81-6.

A spectrophotometric assay for P5CDh was shown to be valid if rotenone was included in the assay to prevent reoxidation of NADH.
P5CDh is enriched only in the mitochondrial fractions, as are the mitochondrial enzymes, succinate cytochrome c reductase, proline oxidase, glutaminase, and ornithine aminotransferase.
1(0,0,0,1) Details
7318831 Mommsen TP, Hochachka PW: Respiratory and enzymatic properties of squid heart mitochondria. . Eur J Biochem. 1981 Nov;120(2):345-50.

Rotenone inhibited state-3 respiration of malate, proline, ornithine and pyrroline carboxylate.
Key enzymes in proline and ornithine oxidation, i.e. proline dehydrogenase, pyrroline-carboxylate dehydrogenase, ornithine aminotransferase, and glutamate dehydrogenase were located in the mitochondria.
1(0,0,0,1) Details
11007319 Levillain O, Diaz JJ, Reymond I, Soulet D: Ornithine metabolism along the female mouse nephron: localization of ornithine decarboxylase and ornithine aminotransferase. Pflugers Arch. 2000 Sep;440(5):761-9.

Gabaculine, a suicide inhibitor of OAT, and rotenone sharply decreased the production of 14CO2 from [1-14C] ornithine.
1(0,0,0,1) Details