| Name | caspase 3 |
|---|---|
| Synonyms | Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11078378 | Yuki K, Miyauchi T, Kakinuma Y, Murakoshi N, Suzuki T, Hayashi J, Goto K, Yamaguchi I: Mitochondrial dysfunction increases expression of endothelin-1 and induces apoptosis through caspase-3 activation in rat cardiomyocytes in vitro. J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S205-8. Furthermore, treatment of cardiomyocytes with rotenone induced an elevation of caspase-3 activity, and caused a marked increase in DNA laddering, an indication of apoptosis. |
7(0,0,1,2) | Details |
| 16787641 | Ito Y, Oh-Hashi K, Kiuchi K, Hirata Y: p44/42 MAP kinase and c-Jun N-terminal kinase contribute to the up-regulation of caspase-3 in -induced apoptosis in PC12 cells. Brain Res. 2006 Jul 12;1099(1):1-7. Epub 2006 Jun 19. Up-regulation of caspase-3 protein was evident in -treated PC12 cells and was moderate in cisplatin-, rotenone- and A23187-treated cells but was not observed in serum deprivation-, anisomycin-, camptothecin-, cycloheximide- or staurosporine-treated cells in which all treatments induced extensive DNA fragmentation. |
7(0,0,0,7) | Details |
| 10463952 | Kiningham KK, Oberley TD, Lin S, Mattingly CA, St Clair DK: Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly (ADP- polymerase-mediated cell death. FASEB J. 1999 Sep;13(12):1601-10. Activation of caspase-3 (CPP-32) occurred in the NEO cells independent of cytochrome c release from the mitochondria. MnSOD overexpression specifically protected against cell death upon treatment with rotenone or antimycin. |
1(0,0,0,1) | Details |
| 12111836 | Conn KJ, Gao WW, Ullman MD, McKeon-O'Malley C, Eisenhauer PB, Fine RE, Wells JM: Specific up-regulation of GADD153/CHOP in 1-methyl-4-phenyl-pyridinium-treated SH-SY5Y cells. J Neurosci Res. 2002 Jun 15;68(6):755-60. GADD153 expression increased after 24 hr of MPP (+) (1 mM) exposure and preceded activation of caspase 3. Comparison of GADD153 expression among cultures treated with other toxins whose primary mode of action is either via mitochondrial impairment (rotenone) or via oxidative stress or peroxide) showed that GADD153 was uniquely up-regulated by MPP (+). |
1(0,0,0,1) | Details |
| 9349553 | Schulz JB, Bremen D, Reed JC, Lommatzsch J, Takayama S, Wullner U, Loschmann PA, Klockgether T, Weller M: Cooperative interception of neuronal apoptosis by BCL-2 and BAG-1 expression: prevention of caspase activation and reduced production of reactive species. J Neurochem. 1997 Nov;69(5):2075-86. The peptide inhibitor of caspase activity, N-acetyl-Asp--Val-Asp- was more potent than acetyl-Tyr-Val--Asp-chloromethyl ketone in preventing NGF withdrawal-induced apoptosis, suggesting an important role for caspase-3 (CPP32)-like proteases. |
1(0,0,0,1) | Details |
| 12496265 | Li N, Ragheb K, Lawler G, Sturgis J, Rajwa B, Melendez JA, Robinson JP: Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive species production. J Biol Chem. 2003 Mar 7;278(10):8516-25. Epub 2002 Dec 20. Rotenone-induced apoptosis was confirmed by DNA fragmentation, cytochrome c release, and caspase 3 activity. |
6(0,0,1,1) | Details |
| 12880480 | Sharma SK, Ebadi M: Metallothionein attenuates 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in dopaminergic neurons. Antioxid Redox Signal. 2003 Jun;5(3):251-64. The synthesis of mitochondrial and apoptosis-inducing factors were increased following exposure to 1-methyl-4-phenylpyridinium ion or rotenone. Furthermore, it down-regulated the expression of Bcl-2 and poly (ADP- polymerase, but up-regulated the expression of caspase-3 and Bax in dopaminergic (SK-N-SH) neurons. |
5(0,0,0,5) | Details |
| 14561532 | Tada-Oikawa S, Hiraku Y, Kawanishi M, Kawanishi S: Mechanism for generation of peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis. Life Sci. 2003 Nov 7;73(25):3277-88. Caspase-3 activity increased in HL-60 cells in a time-dependent manner. |
1(0,0,0,1) | Details |
| 16292513 | Lee SJ, Youn YC, Han ES, Lee CS: Depressant effect of mitochondrial respiratory complex inhibitors on proteasome inhibitor-induced mitochondrial dysfunction and cell death in PC12 cells. Neurochem Res. 2005 Sep;30(9):1191-200. The addition of rotenone (inhibitor of respiratory complex I), 3-nitropropionic acid (complex II inhibitor), harmine (inhibitor of complexes I and II) and cyclosporin A (CsA, an inhibitor of the mitochondrial permeability transition) reduced the nuclear damage, loss in the mitochondrial transmembrane potential, cytosolic accumulation of cytochrome c, activation of caspase-3, increase in the formation of reactive species and depletion of in differentiated PC12 cells treated with MG132, a proteasome inhibitor. The addition of rotenone (inhibitor of respiratory complex I), 3-nitropropionic acid (complex II inhibitor), harmine (inhibitor of complexes I and II) and cyclosporin A (CsA, an inhibitor of the mitochondrial permeability transition) reduced the nuclear damage, loss in the mitochondrial transmembrane potential, cytosolic accumulation of cytochrome c, activation of caspase-3, increase in the formation of reactive species and depletion of in differentiated PC12 cells treated with MG132, a proteasome inhibitor. |
1(0,0,0,1) | Details |
| 19885011 | Kim HJ, Song JY, Park HJ, Park HK, Yun DH, Chung JH: Protects against Rotenone-induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells. Korean J Physiol Pharmacol. 2009 Aug;13(4):281-5. Epub 2009 Aug 31. In addition, reduced the enzyme activity of caspase 3 and cleavages of caspase 9, poly (ADP- polymerase (PARP), and caspase 3. |
1(0,0,0,1) | Details |
| 12437580 | Wang X, Qin ZH, Leng Y, Wang Y, Jin X, Chase TN, Bennett MC: inhibits rotenone-induced apoptosis in SH-SY5Y cells. J Neurochem. 2002 Dec;83(5):1094-102. The degeneration of nigral neurons in Parkinson's disease (PD) reportedly involves a defect in brain mitochondrial complex I in association with the activation of nuclear factor-kappaB (NF-kappaB) and caspase-3. |
3(0,0,0,3) | Details |
| 12538580 | De Sarno P, Shestopal SA, King TD, Zmijewska A, Song L, Jope RS: Muscarinic receptor activation protects cells from apoptotic effects of DNA damage, oxidative stress, and mitochondrial inhibition. J Biol Chem. 2003 Mar 28;278(13):11086-93. Epub 2003 Jan 21. Exposure of human neuroblastoma SH-SY5Y cells to the DNA-damaging agent camptothecin increased p53 levels, activated caspase-3, and caused cell death. Muscarinic receptor stimulation also protected cells from caspase-3 activation induced by exposure to rotenone, a mitochondrial complex 1 inhibitor, but no protection was evident from staurosporine-induced caspase-3 activation. |
3(0,0,0,3) | Details |
| 16157303 | Nutku E, Hudson SA, Bochner BS: Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury. Biochem Biophys Res Commun. 2005 Oct 28;336(3):918-24. Siglec-8 crosslinking induced rapid cleavage of caspase-3, caspase-8, and caspase-9 in eosinophils. Rotenone and antimycin, inhibitors of mitochondrial respiratory chain components, completely inhibited apoptosis. |
1(0,0,0,1) | Details |
| 18218673 | Jin S, Ray RM, Johnson LR: TNF-alpha/cycloheximide-induced apoptosis in intestinal epithelial cells requires Rac1-regulated reactive species. Am J Physiol Gastrointest Liver Physiol. 2008 Apr;294(4):G928-37. Epub 2008 Jan 24. Lastly, all ROS inhibitors inhibited caspase-3 activity. The antioxidant, (NAC), or rotenone (Rot), the mitochondrial electron transport chain inhibitor, attenuated mitochondrial ROS production and apoptosis. |
1(0,0,0,1) | Details |
| 11046005 | Torres-Roca JF, Tung JW, Greenwald DR, Brown JM, Herzenberg LA, Herzenberg LA, Katsikis PD: An early -dependent step is required for dexamethasone-induced apoptosis of immature mouse thymocytes. J Immunol. 2000 Nov 1;165(9):4822-30. In addition, hypoxia inhibited the activation by Dex of caspase-3 (CPP32)-like proteases. |
2(0,0,0,2) | Details |
| 10597238 | Suzuki S, Higuchi M, Proske RJ, Oridate N, Hong WK, Lotan R: Implication of mitochondria-derived reactive species, cytochrome C and caspase-3 in N-(4-hydroxyphenyl) retinamide-induced apoptosis in cervical carcinoma cells. Oncogene. 1999 Nov 4;18(46):6380-7. Rotenone, an MRC complex I inhibitor was less effective and azide, an MRC complex IV inhibitor, exhibited a marginal effect. |
2(0,0,0,2) | Details |
| 18334950 | Wood JP, Lascaratos G, Bron AJ, Osborne NN: The influence of visible light exposure on cultured RGC-5 cells. Mol Vis. 2007 Feb 11;14:334-44. A subset of cells was treated with 100 pM rotenone as an alternative means to induce metabolic stress; this was to determine that the influence of light on compromised cells was not specific to serum-deprivation alone. RESULTS: Exposure to the light for 48 h activated both caspase-3 and Bcl-associated X-protein (Bax) in cultured RGC-5 cells. |
1(0,0,0,1) | Details |
| 17540012 | Egea J, Rosa AO, Cuadrado A, Garcia AG, Lopez MG: Nicotinic receptor activation by epibatidine induces heme oxygenase-1 and protects chromaffin cells against oxidative stress. J Neurochem. 2007 Sep;102(6):1842-52. Epub 2007 Jun 1. In this context, we investigated here if the exposure of bovine chromaffin cells to the potent nAChR agonist epibatidine protected against rotenone (30 micromol/L) plus oligomycin (10 micromol/L) (rot/oligo) toxicity, an in vitro model of mitochondrial ROS production. Mitochondrial depolarization, ROS, and caspase 3 active produced by rot/oligo were also prevented by epibatidine. |
1(0,0,0,1) | Details |
| 15659217 | Li J, Spletter ML, Johnson DA, Wright LS, Svendsen CN, Johnson JA: Rotenone-induced caspase 9/3-independent and -dependent cell death in undifferentiated and differentiated human neural stem cells. J Neurochem. 2005 Feb;92(3):462-76. |
0(0,0,0,0) | Details |
| 15808420 | Aronis A, Madar Z, Tirosh O: Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial reactive species production and cellular necrosis. Free Radic Biol Med. 2005 May 1;38(9):1221-30. Within the first 24 h after TG treatment, cellular reactive species (ROS) levels were strongly elevated and basal caspase-3 activity was attenuated. TG-mediated ROS production was demonstrated to be via mitochondrial complex 1 of the electron-transfer chain since the inhibitor of complex 1 rotenone significantly attenuated the cellular ROS levels in TG-treated cells. |
2(0,0,0,2) | Details |
| 18602972 | Choi EJ, Han JH, Lee CS: Prostaglandin analogue misoprostol attenuates neurotoxin 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death in differentiated PC12 cells. Brain Res Bull. 2008 Jul 3. Treatment with misoprostol significantly attenuated the MPP (+)-induced mitochondrial membrane permeability change that leads to the increase in pro-apoptotic Bax and Cytochrome c levels, and subsequent caspase-3 activation. Misoprostol significantly attenuated another parkinsonian neurotoxin rotenone-induced cell death. |
2(0,0,0,2) | Details |
| 11078377 | Kakinuma Y, Miyauchi T, Yuki K, Murakoshi N, Goto K, Yamaguchi I: Mitochondrial dysfunction of cardiomyocytes causing impairment of cellular energy metabolism induces apoptosis, and concomitant increase in cardiac endothelin-1 expression. J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S201-4. In this study, we applied mitochondrial inhibitors, such as rotenone, and antimycin A, which inhibit mitochondrial function at different sites of the mitochondrial respiratory chain, to cardiomyocytes. |
0(0,0,0,0) | Details |
| 19198139 | Takeda A, Sugeno N, Hasegawa T, Kobayashi M, Kikuchi A: [Cellular pathophysiology of Parkinson's disease] . Rinsho Shinkeigaku. 2008 Nov;48(11):984-5. The data thus obtained suggested the followings. (1) By the treatment with rotenone, wild type alpha-synuclein overexpressing cells demonstrated intracellular aggregations, which shared a number of features with Lewy bodies. (2) The aggregate formation of alpha-synuclein may be cytoprotective. (3) The -derived quinones are candidate molecules to facilitate the oligomer formation of a-synuclein. (4) The cells overexpressing S129A mutant showed few aggregations. |
0(0,0,0,0) | Details |
| 19539006 | Kim HJ, Park HJ, Park HK, Chung JH: Tranexamic acid protects against rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells. Toxicology. 2009 Aug 3;262(2):171-4. Epub 2009 Jun 16. |
0(0,0,0,0) | Details |
| 14672949 | Sawada H, Kohno R, Kihara T, Izumi Y, Sakka N, Ibi M, Nakanishi M, Nakamizo T, Yamakawa K, Shibasaki H, Yamamoto N, Akaike A, Inden M, Kitamura Y, Taniguchi T, Shimohama S: Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions. J Biol Chem. 2004 Mar 12;279(11):10710-9. Epub 2003 Dec 12. Here we report that a combination of 1-methyl-4-phenylpyridinium ion (MPP (+)) or rotenone and proteasome inhibition causes the appearance of alpha-synuclein-positive inclusion bodies. MPP (+) elevated proteasome activity, dephosphorylated mitogen-activating protein kinase (MAPK), and activated caspase-3. |
2(0,0,0,2) | Details |
| 12962151 | Tsuruga M, Dang Y, Shiono Y, Oka S, Yamazaki Y: Differential effects of and three hydrophilic antioxidants on the actinomycin D-induced and colcemid-accelerated apoptosis in human leukemia CMK-7 cell line. Mol Cell Biochem. 2003 Aug;250(1-2):131-7. Caspase-3 activation and DNA fragmentation were both suppressed by (VE), t-butylhydroxyanisole, and |
2(0,0,0,2) | Details |
| 12153473 | Poppe M, Reimertz C, Munstermann G, Kogel D, Prehn JH: -induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression. J Neurochem. 2002 Aug;82(3):482-94. Treatment with the complex I inhibitor rotenone, C2- or C8- induced cell death in D283 control cells, while rho- cells were significantly protected. |
0(0,0,0,0) | Details |
| 17581813 | Marella M, Seo BB, Matsuno-Yagi A, Yagi T: Mechanism of cell death caused by complex I defects in a rat dopaminergic cell line. J Biol Chem. 2007 Aug 17;282(33):24146-56. Epub 2007 Jun 20. We have shown that expression of a rotenone-insensitive yeast -quinone oxidoreductase (Ndi1) can rescue mammalian cells from complex I dysfunction. |
0(0,0,0,0) | Details |
| 17314199 | Yim SB, Park SE, Lee CS: Protective effect of glycyrrhizin on 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death in differentiated PC12 cells. J Pharmacol Exp Ther. 2007 May;321(2):816-22. Epub 2007 Feb 21. MPP+ induced the nuclear damage, the changes in the mitochondrial membrane permeability, leading to the cytochrome c release and caspase-3 activation, the formation of reactive species, and the depletion of (GSH) in differentiated PC12 cells. The protective effect of licorice compounds was also detected in the rotenone-treated PC12 cells. |
1(0,0,0,1) | Details |
| 16716839 | Lee CS, Yim SB, Song JH, Han ES: Econazole attenuates cytotoxicity of 1-methyl-4-phenylpyridinium by suppressing mitochondrial membrane permeability transition. Brain Res Bull. 2006 May 31;69(6):687-94. Epub 2006 Apr 24. Econazole (0.25-2.5 microM) inhibited the cytotoxicity of MPP (+) or rotenone. The results show that econazole at the low concentrations may reduce the MPP (+)-induced viability loss in PC12 cells by suppressing the mitochondrial permeability transition, leading to activation of caspase-3 and the elevation of intracellular Ca (2+) levels, which are associated with the increased formation of ROS and depletion of GSH. |
1(0,0,0,1) | Details |
| 16678157 | Lai JS, Zhao C, Warsh JJ, Li PP: Cytoprotection by lithium and varies between cell types and cellular stresses. Eur J Pharmacol. 2006 Jun 6;539(1-2):18-26. Epub 2006 Apr 5. Pretreatment of SH-SY5Y cells for 7 days, but not 1 day, with 1 mM of lithium or 0.6 mM of significantly reduced rotenone and H2O2-induced cytotoxicity, cytochrome c release and caspase-3 activation, and increased Bcl-2 levels. |
0(0,0,0,0) | Details |
| 10987825 | Bal-Price A, Brown GC: -induced necrosis and apoptosis in PC12 cells mediated by mitochondria. J Neurochem. 2000 Oct;75(4):1455-64. A 24-h incubation of PC12 cells with NO donors (SNAP or NOC-18) or specific inhibitors of mitochondrial respiration (myxothiazol, rotenone, or azide), in the absence of caused total ATP depletion and resulted in 80-100% necrosis. |
0(0,0,0,0) | Details |
| 10973919 | Deshpande SS, Angkeow P, Huang J, Ozaki M, Irani K: Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive species. FASEB J. 2000 Sep;14(12):1705-14. Rotenone, a mitochondrial electron transport chain inhibitor, suppressed TNF-induced mitochondrial ROS production, proteolytic cleavage of procaspase-3, and apoptosis. Expression of Rac1N17 blocked TNF-induced activation of nuclear factor-kappa B (NF-kappaB), increased activity of caspase-3, and markedly augmented endothelial cell susceptibility to TNF-induced apoptosis. |
1(0,0,0,1) | Details |
| 18201823 | Nakaso K, Ito S, Nakashima K: activates the PI3K/Akt pathway and prevents apoptotic cell death in a Parkinson's disease model of SH-SY5Y cells. Neurosci Lett. 2008 Feb 20;432(2):146-50. Epub 2007 Dec 23. prevented the apoptotic cell death induced by serum/ (RA) deprivation, MPP+, rotenone, and 6-OHDA in SH-SY5Y cells in a dose dependent manner. lowered caspase-3 activity induced by serum/RA deprivation and 6-OHDA administration, and also decreased the number of apoptotic condensed and/or fragmented nuclei. |
1(0,0,0,1) | Details |
| 19631247 | Liang JH, Du J, Xu LD, Jiang T, Hao S, Bi J, Jiang B: Catalpol protects primary cultured cortical neurons induced by Abeta (1-42) through a mitochondrial-dependent caspase pathway. Neurochem Int. 2009 Dec;55(8):741-6. Epub 2009 Jul 22. It has been reported that catalpol, an iridoid glucoside, isolated from the root of Rehmannia glutinosa, protected cells from damage induced by a variety of toxic stimulus such as LPS, MPP (+) and rotenone. |
0(0,0,0,0) | Details |
| 12551850 | Pei W, Liou AK, Chen J: Two caspase-mediated apoptotic pathways induced by rotenone toxicity in cortical neuronal cells. FASEB J. 2003 Mar;17(3):520-2. Epub 2003 Jan 22. |
0(0,0,0,0) | Details |
| 19850127 | Ruan Q, Harrington AJ, Caldwell KA, Caldwell GA, Standaert DG: VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease. Neurobiol Dis. 2010 Feb;37(2):330-8. Epub 2009 Oct 20. In SH-SY5Y neuroblastoma cell lines stably transfected with hVPS41, we determined that presence of this protein conferred protection against the neurotoxins 6-OHDA and rotenone. |
0(0,0,0,0) | Details |
| 15131242 | Morioka N, Kumagai K, Morita K, Kitayama S, Dohi T: Nonsteroidal anti-inflammatory drugs potentiate 1-methyl-4-phenylpyridinium (MPP+)-induced cell death by promoting the intracellular accumulation of MPP+ in PC12 cells. J Pharmacol Exp Ther. 2004 Aug;310(2):800-7. Epub 2004 May 6. In contrast, these NSAIDs had no effect on rotenone-induced cell death. |
0(0,0,0,0) | Details |
| 15996779 | Sanchez-Reus MI, Peinado II, Molina-Jimenez MF, Benedi J: Fraxetin prevents rotenone-induced apoptosis by induction of endogenous in human neuroblastoma cells. Neurosci Res. 2005 Sep;53(1):48-56. |
0(0,0,0,0) | Details |
| 17292807 | Kim YJ, Ko HH, Han ES, Lee CS: inhibition of rotenone- or 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death. Brain Res Bull. 2007 Mar 30;71(6):633-40. Epub 2007 Jan 8. The results show that seems to reduce the cytotoxicity of rotenone and MPP+ by suppressing the mitochondrial permeability transition formation, leading to cytochrome c release and subsequent activation of caspase-3. |
143(1,3,3,3) | Details |
| 14622122 | Ahmadi FA, Linseman DA, Grammatopoulos TN, Jones SM, Bouchard RJ, Freed CR, Heidenreich KA, Zawada WM: The pesticide rotenone induces caspase-3-mediated apoptosis in ventral mesencephalic dopaminergic neurons. J Neurochem. 2003 Nov;87(4):914-21. |
94(0,3,3,4) | Details |
| 15447660 | Akundi RS, Macho A, Munoz E, Lieb K, Bringmann G, Clement HW, Hull M, Fiebich BL: 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline-induced apoptosis in the human neuroblastoma cell line SK-N-SH. J Neurochem. 2004 Oct;91(2):263-73. In this study, we report that TaClo induces an apoptotic pathway in the human neuroblastoma cell line, SK-N-SH, involving the translocation of mitochondrial cytochrome c to the cytosol and activation of caspase 3. TaClo-induced apoptosis shows considerable differences from that mediated by other Parkinson-inducing agents such as MPTP, rotenone and |
1(0,0,0,1) | Details |
| 16458199 | Poliandri AH, Machiavelli LI, Quinteros AF, Cabilla JP, Duvilanski BH: protects the mitochondria of anterior pituitary cells and prevents cadmium-induced cell death by reducing oxidative stress. Free Radic Biol Med. 2006 Feb 15;40(4):679-88. Epub 2005 Oct 21. We have previously shown that Cd2+ induces caspase-3 activation and apoptosis of anterior pituitary cells and that endogenous (NO) protects these cells from Cd2+. This effect was electron-transfer-chain-dependent since it was inhibited by rotenone. |
1(0,0,0,1) | Details |
| 14698482 | Diaz-Corrales FJ, Asanuma M, Miyazaki I, Ogawa N: Rotenone induces disassembly of the Golgi apparatus in the rat dopaminergic neuroblastoma B65 cell line. Neurosci Lett. 2004 Jan 2;354(1):59-63. |
0(0,0,0,0) | Details |
| 16120427 | Blanco FJ, Lopez-Armada MJ, Maneiro E: Mitochondrial dysfunction in osteoarthritis. . Mitochondrion. 2004 Sep;4(5-6):715-28. Epub 2004 Oct 1. Inhibition of complex I with rotenone increases the expression and synthesis of Bcl-2 and Cox-2, both effects are similar effects to produced by IL-1 in human chondrocytes. |
0(0,0,0,0) | Details |
| 19723537 | Park HJ, Kim HJ, Park HK, Chung JH: Protective effect of histamine H2 receptor antagonist against rotenone-induced apoptosis. Neurotoxicology. 2009 Nov;30(6):1114-9. Epub 2009 Aug 31. |
0(0,0,0,0) | Details |
| 17367952 | Samantaray S, Knaryan VH, Guyton MK, Matzelle DD, Ray SK, Banik NL: The parkinsonian neurotoxin rotenone activates calpain and caspase-3 leading to motoneuron degeneration in spinal cord of Lewis rats. Neuroscience. 2007 May 11;146(2):741-55. Epub 2007 Mar 23. |
88(1,1,2,3) | Details |
| 11689167 | King TD, Bijur GN, Jope RS: Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium. Brain Res. 2001 Nov 16;919(1):106-14. Rotenone-induced activation of caspase-3 was enhanced by inhibition of PI3K or increased GSK3beta activity, and was attenuated by inhibiting GSK3beta with lithium. |
87(1,1,1,7) | Details |
| 17018646 | Ramachandiran S, Hansen JM, Jones DP, Richardson JR, Miller GW: Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation. Toxicol Sci. 2007 Jan;95(1):163-71. Epub 2006 Oct 3. |
82(1,1,1,2) | Details |
| 15569251 | Gu M, Iravani MM, Cooper JM, King D, Jenner P, Schapira AH: Pramipexole protects against apoptotic cell death by non-dopaminergic mechanisms. J Neurochem. 2004 Dec;91(5):1075-81. However, pramipexole reduced caspase-3 activation, decreased the release of cytochrome c and prevented the fall in the mitochondrial membrane potential induced by MPP+ and rotenone. |
81(1,1,1,1) | Details |
| 16004991 | Wang G, Qi C, Fan GH, Zhou HY, Chen SD: PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone. FEBS Lett. 2005 Jul 18;579(18):4005-11. Thus, our results demonstrate that PACAP27 has a neuroprotective role against rotenone-induced neurotoxicity in neuronal differentiated PC12 cells and the neuroprotective effects of PACAP are associated with activation of MAP kinase pathways by PKA and with inhibition of caspase-3 activity; the signaling mechanism appears to be mediated through mitochondrial-independent pathways. |
81(1,1,1,1) | Details |
| 19874289 | Avila-Gomez IC, Velez-Pardo C, Jimenez-Del-Rio M: Effects of insulin-like growth factor-1 on rotenone-induced apoptosis in human lymphocyte cells. Basic Clin Pharmacol Toxicol. 2010 Jan;106(1):53-61. Epub 2009 Oct 28. The present work shows that rotenone, a mitochondrial complex I inhibitor, induced time- and concentration-dependent apoptosis in lymphocytes which was mediated by anion radicals (O (2)*(-))/ peroxide, depolarization of mitochondria, caspase-3 activation, concomitantly with the nuclear translocation of transcription factors such as NF-kappaB, p53, c-Jun and nuclei fragmentation. |
81(1,1,1,1) | Details |
| 9824162 | Higuchi M, Proske RJ, Yeh ET: Inhibition of mitochondrial respiratory chain complex I by TNF results in cytochrome c release, membrane permeability transition, and apoptosis. Oncogene. 1998 Nov 12;17(19):2515-24. This hypothesis is supported by the following observations: (1) TNF and rotenone induced MPT and cytochrome c release; (2) TNF-induced complex I inhibition was observed prior to cytochrome c release and MPT induction; (3) MPT induction was inhibited by a caspase 3 inhibitor, z-DEVD-CH2F, and an antioxidant pyrrolidine dithiocarbamate (PDTC), whereas cytochrome c release was only inhibited by PDTC. |
32(0,1,1,2) | Details |
| 18840762 | Eley HL, Russell ST, Tisdale MJ: Mechanism of attenuation of muscle protein degradation induced by tumor necrosis factor-alpha and angiotensin II by Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1417-26. Epub 2008 Oct 7. There was an increase in formation of reactive species (ROS) within 30 min, as well as an increase in the activity of both caspase-3 and -8, and both effects were attenuated by HMB. Formation of ROS was attenuated by rotenone, an inhibitor of the mitochondrial electron transport chain, nitro- methyl ester, an inhibitor of synthase, and SB 203580, a specific inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), which also attenuated total protein degradation. |
4(0,0,0,4) | Details |
| 19351880 | Bayir H, Kapralov AA, Jiang J, Huang Z, Tyurina YY, Tyurin VA, Zhao Q, Belikova NA, Vlasova II, Maeda A, Zhu J, Na HM, Mastroberardino PG, Sparvero LJ, Amoscato AA, Chu CT, Greenamyre JT, Kagan VE: Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease. J Biol Chem. 2009 Jun 5;284(23):15951-69. Epub 2009 Apr 7. Co-localization of Syn with cytochrome c was detected in aggregates formed upon proapoptotic stimulation of SH-SY5Y and HeLa cells and in dopaminergic substantia nigra neurons of rotenone-treated rats. Syn- exerted protection against cytochrome c-induced caspase-3 activation in a cell-free system, particularly in the presence of H (2) O (2). |
2(0,0,0,2) | Details |
| 14642398 | Gil J, Almeida S, Oliveira CR, Rego AC: Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis. Free Radic Biol Med. 2003 Dec 1;35(11):1500-14. The antioxidants idebenone (IDB), -ethylester (GSH/EE), trolox, and Mn (III) tetrakis (4- (MnTBAP) significantly reduced STS-induced caspase-3-like activity and intracellular ROS generation. Endogenous sources of ROS production were investigated by testing the effect of the following inhibitors: 7-nitroindazole (7-NI), a specific inhibitor of the neuronal isoform of synthase (nNOS); arachidonyl trifluoromethyl ketone (AACOCF (3)), a phospholipase A (2) (PLA (2)) inhibitor; allopurinol, a xanthine oxidase inhibitor; and the mitochondrial inhibitors rotenone and oligomycin. |
2(0,0,0,2) | Details |
| 12588799 | Darios F, Corti O, Lucking CB, Hampe C, Muriel MP, Abbas N, Gu WJ, Hirsch EC, Rooney T, Ruberg M, Brice A: Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death. Hum Mol Genet. 2003 Mar 1;12(5):517-26. In this cell line, neuronally differentiated by nerve growth factor, Parkin overproduction protected against cell death mediated by but not by a variety of other cell death inducers (H (2) O (2), rotenone, 6-OHDA, tunicamycin, 2-mercaptoethanol and staurosporine). Interestingly, Parkin acted by delaying mitochondrial swelling and subsequent cytochrome c release and caspase-3 activation observed in -mediated cell death. |
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| 12675912 | Shang T, Uihlein AV, Van Asten J, Kalyanaraman B, Hillard CJ: 1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3. J Neurochem. 2003 Apr;85(2):358-67. MPP+-induced caspase-3-like activation and cell death are prevented by pretreatment with 5 micro mbeta- In contrast, the effects of rotenone are unaffected by |
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| 9989825 | Dumont A, Hehner SP, Hofmann TG, Ueffing M, Droge W, Schmitz ML: peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive species and the activation of NF-kappaB. Oncogene. 1999 Jan 21;18(3):747-57. H2O2-triggered cell death led to the induced cleavage and activation of Caspase-3. Inhibition of the mitochondrial permeability transition by bongkrekic acid (BA), or interference with the mitochondrial electron transport system by rotenone or prevented the cytotoxic effect of H2O2. |
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| 16402917 | Reinecke F, Levanets O, Olivier Y, Louw R, Semete B, Grobler A, Hidalgo J, Smeitink J, Olckers A, Van der Westhuizen FH: Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-treated HeLa cells. Biochem J. 2006 Apr 15;395(2):405-15. MT2A overexpression in rotenone-treated cells also significantly reduced or delayed apoptosis induction, as measured by caspase 3/7 activity and cytosolic nucleosome enrichment. |
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| 17900545 | Chung WG, Miranda CL, Maier CS: potentiates the cytotoxicity of rotenone in neuroblastoma SH-SY5Y cells. Brain Res. 2007 Oct 24;1176:133-42. Epub 2007 Aug 22. The exacerbating effect of on rotenone toxicity may involve an apoptotic mechanism as shown by the enhancement of caspase-3 activity and activation of other caspases in rotenone-treated SH-SY5Y cells. |
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| 10549166 | Khar A, Ali AM, Begum Z, Pardhasaradhi BV, Varalakshmi C: Induction of apoptosis in AK-5 cells by rotenone involves participation of caspases. Indian J Biochem Biophys. 1999 Apr;36(2):77-81. DEVD which is a specific inhibitor of caspase 3, inhibited apoptosis in AK-5 cells. |
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| 16797712 | Berry EV, Toms NJ: and limit zinc-induced oxidative HT-22 neuronal cell injury. Neurotoxicology. 2006 Dec;27(6):1043-51. Epub 2006 May 22. We conclude that cultured HT-22 neurones are vulnerable to Zn (2+) cytotoxic insults via a non-caspase-3 mediated mechanism, which involves glycolytic inhibition. |
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| 18344945 | Wood JP, Lascaratos G, Bron AJ, Osborne NN: The influence of visible light exposure on cultured RGC-5 cells. Mol Vis. 2007 Feb 11;14:334-44. A subset of cells was treated with 100 pM rotenone as an alternative means to induce metabolic stress; this was to determine that the influence of light on compromised cells was not specific to serum-deprivation alone. RESULTS: Exposure to the light for 48 h activated both caspase-3 and Bcl-associated X-protein (Bax) in cultured RGC-5 cells. |
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| 16917840 | Imamura K, Takeshima T, Kashiwaya Y, Nakaso K, Nakashima K: D- protects dopaminergic SH-SY5Y cells in a rotenone model of Parkinson's disease. J Neurosci Res. 2006 Nov 1;84(6):1376-84. Whereas rotenone caused the loss of mitochondrial membrane potential, released cytochrome c into the cytosol, and reduced cytochrome c content in mitochondria, addition of bHB blocked this toxic effect. bHB also attenuated the rotenone-induced activation of caspase-9 and caspase-3. |
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| 15812315 | King TD, Jope RS: Inhibition of glycogen synthase kinase-3 protects cells from intrinsic but not extrinsic oxidative stress. Neuroreport. 2005 Apr 25;16(6):597-601. Both intrinsic oxidative stress induced by the mitochondrial inhibitor rotenone and extrinsic oxidative stress induced by exogenously added H2O2 activated Bax, caspase-2, and caspase-3 in human neuroblastoma SH-SY5Y cells. |
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| 19497415 | Santos DM, Santos MM, Viana RJ, Castro RE, Moreira R, Rodrigues CM: Naphtho [2,3-d] isoxazole-4,9-dione-3-carboxylates: potent, non-cytotoxic, antiapoptotic agents. Chem Biol Interact. 2009 Jul 15;180(2):175-82. Epub 2009 Mar 24. Both 1a and 1b significantly increased cell viability, while reducing nuclear fragmentation, caspase-3, -8 and -9 activation, and cytochrome c release induced by camptothecin. Similar protective effects of derivatives were seen in HuH-7 and PC12 cells incubated with distinct apoptotic stimuli, such as camptothecin, TGF-beta1, or rotenone. |
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| 18562315 | Sugeno N, Takeda A, Hasegawa T, Kobayashi M, Kikuchi A, Mori F, Wakabayashi K, Itoyama Y: Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death. J Biol Chem. 2008 Aug 22;283(34):23179-88. Epub 2008 Jun 18. Following the treatment with rotenone, a mitochondrial complex I inhibitor, wild type alpha-synuclein-overexpressing cells demonstrated intracellular aggregations, which shared a number of features with Lewy bodies, although cells overexpressing the S129A mutant, in which phosphorylation at Ser (129) was blocked, showed few aggregations. Moreover, induction of unfolded protein response (UPR) markers was evident several hours before the induction of mitochondrial disruption and caspase-3 activation. |
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| 20226830 | Cuello S, Goya L, Madrid Y, Campuzano S, Pedrero M, Bravo L, Camara C, Ramos S: Molecular mechanisms of methylmercury-induced cell death in human HepG2 cells. Food Chem Toxicol. 2010 Mar 10. Caspase-3 activity reached a maximum value at 8h and continued increased up to 24h. |
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| 11054104 | Follstad BD, Wang DI, Stephanopoulos G: Mitochondrial membrane potential differentiates cells resistant to apoptosis in hybridoma cultures. Eur J Biochem. 2000 Nov;267(22):6534-40. This hypothesis was tested by separating a hybridoma cell population into subpopulations of varying mitochondrial membrane potential (MMP) using Rhodamine 123 stain and fluorescence-activated cell sorter analysis and subjecting them to two apoptosis inducers, rotenone and staurosporin. Apoptotic death was characterized morphologically through the determination of apoptosis-related chromatin condensation and biochemically through the measurement of caspase-3 enzymatic activity. |
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| 12800192 | Weitsman GE, Ravid A, Liberman UA, Koren R: enhances caspase-dependent and -independent TNFalpha-induced breast cancer cell death: The role of reactive species and mitochondria. Int J Cancer. 2003 Aug 20;106(2):178-86. The effect of on DeltaPsi was mimicked by rotenone, which increased both the drop in DeltaPsi and caspase activation induced by TNFalpha. It increased caspase-3-like activity as assayed by the cleavage of poly-(ADP- polymerase and of the fluorogenic substrate ac-DEVD-AMC. |
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| 18082360 | Liu YM, Jiang B, Bao YM, An LJ: inhibits apoptosis by mitochondrial dysfunction in rotenone-induced PC12 cells. Toxicol In Vitro. 2008 Mar;22(2):430-7. Epub 2007 Nov 7. The apoptosis in rotenone-induced PC12 cells was accompanied by the loss of mitochondrial membrane potential, the formation of reactive species (ROS), the total depletion, activation of caspase-3 and down-regulation of Bcl-2. |
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| 19857556 | Li X, Liu Z, Tamashiro K, Shi B, Rudnicki DD, Ross CA, Moran TH, Smith WW: Synphilin-1 exhibits trophic and protective effects against Rotenone toxicity. Neuroscience. 2010 Jan 20;165(2):455-62. Epub . We found that Rotenone induced apoptotic cell death in N1E-115 cells via caspase-3 activation and poly (ADP- polymerase (PARP) cleavage. |
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| 19747897 | Preta G, de Klark R, Glas R: A role for nuclear translocation of tripeptidyl-peptidase II in reactive species-dependent DNA damage responses. Biochem Biophys Res Commun. 2009 Nov 27;389(4):575-9. Epub 2009 Sep 10. This correlated with reduced nuclear expression of p53 as well as caspase-3 and -9 activation in gamma-irradiated lymphoma cells. Further, this required cellular production of ROS; treatment with either N-acetyl- (anti-oxidant) or Rotenone (inhibitor of mitochondrial respiration) inhibited nuclear accumulation of TPPII. |
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| 19781773 | Ito S, Oyake T, Murai K, Ishida Y: Deguelin suppresses cell proliferation via the inhibition of survivin expression and STAT3 phosphorylation in HTLV-1-transformed T cells. Leuk Res. 2010 Mar;34(3):352-7. Epub 2009 Sep 24. We also observed the cleavage of caspase-3 and poly (ADP- polymerase (PARP) in deguelin-treated cells, indicating that deguelin induces caspase-dependent apoptosis in these cells. |
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| 19610261 | Lee YA, Shin MH: Mitochondrial respiration is required for activation of ERK1/2 and caspase-3 in human eosinophils stimulated with peroxide. J Investig Allergol Clin Immunol. 2009;19(3):188-94. peroxide-triggered activation of caspase-3 and ERK1/2 was attenuated by pretreatment with rotenone. |
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| 12860476 | Molina-Jimenez MF, Sanchez-Reus MI, Benedi J: Effect of fraxetin and on rotenone-induced cytotoxicity in SH-SY5Y cells: comparison with Eur J Pharmacol. 2003 Jul 4;472(1-2):81-7. Rotenone-induced apoptosis in SH-SY5Y cells was detected by an increase in caspase-3 activity and in the cleavage of poly (ADP- polymerase. |
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| 15659109 | Liu HQ, Zhu XZ, Weng EQ: Intracellular oxidation mediates rotenone-induced apoptosis in PC12 cells. Acta Pharmacol Sin. 2005 Jan;26(1):17-26. Caspase-3-like activity was measured by fluorescence assay using the probe Ac-DEVD-AMC. |
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| 15627486 | Mercer LD, Kelly BL, Horne MK, Beart PM: Dietary polyphenols protect neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures. Biochem Pharmacol. 2005 Jan 15;69(2):339-45. Epub 2004 Nov 23. Primary mesencephalic cultures were sensitive to oxidative insults peroxide, rotenone, and N-methyl-4-phenyl-1,2,3,6-tetrahydropyridinium hydrochloride (MPP+)) which produced concentration-dependent decreases in cellular viability across an apoptotic-necrotic continuum of injury. When the neuroprotection of against MPP+-induced injury was compared to that produced by the caspase-3 inhibitor, Z-DVED-FMK, both reduced DNA fragmentation and the injury patterns of TH-positive neurones. |
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| 15198987 | Jiang H, Ren Y, Zhao J, Feng J: Parkin protects human dopaminergic neuroblastoma cells against -induced apoptosis. Hum Mol Genet. 2004 Aug 15;13(16):1745-54. Epub 2004 Jun 15. Here, we show that overexpression of parkin protected human DA neuroblastoma cell line (SH-SY5Y) against apoptosis induced by DA or 6-OHDA, but not by H (2) O (2) or rotenone. Parkin significantly attenuated -induced activation of c-Jun N-terminal kinase (JNK) and caspase-3. |
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| 14732287 | Herrera B, Murillo MM, Alvarez-Barrientos A, Beltran J, Fernandez M, Fabregat I: Source of early reactive species in the apoptosis induced by transforming growth factor-beta in fetal rat hepatocytes. Free Radic Biol Med. 2004 Jan 1;36(1):16-26. Diphenyleneiodonium, which inhibits oxidase and other flavoproteins, completely blocked the increase in ROS induced by TGF-beta, coincidently with an impairment of caspase-3 activation and cell death. Rotenone, an inhibitor of the NADH dehydrogenase in mitochondrial complex I, attenuated, but did not completely inhibit, ROS-production, caspase activation, and cell death mediated by TGF-beta. |
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| 12177198 | Sherer TB, Betarbet R, Stout AK, Lund S, Baptista M, Panov AV, Cookson MR, Greenamyre JT: An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J Neurosci. 2002 Aug 15;22(16):7006-15. In response to H2O2, there was cytochrome c release from mitochondria, caspase-3 activation, and apoptosis, all of which occurred earlier and to a much greater extent in rotenone-treated cells; caspase inhibition provided substantial protection. |
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| 16412576 | Chen MJ, Yap YW, Choy MS, Koh CH, Seet SJ, Duan W, Whiteman M, Cheung NS: Early induction of calpains in rotenone-mediated neuronal apoptosis. Neurosci Lett. 2006 Apr 10-17;397(1-2):69-73. Epub 2006 Jan 10. Immunoblot results revealed calpain activation occurred at 5, 10h prior to caspase-3 activation (at 15 h), suggesting calpain activation was an earlier cellular event compared to caspase activation in the rotenone-mediated apoptosis. |
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| 12388087 | Huang YC, Soukup J, Harder S, Becker S: Mitochondrial oxidant production by a pollutant dust and NO-mediated apoptosis in human alveolar macrophage. Am J Physiol Cell Physiol. 2003 Jan;284(1):C24-32. Epub 2002 Sep 11. ROFA-stimulated ROS production was attenuated by DPI, rotenone, antimycin, and NaN (3), but not by L-NAME, a pattern mimicked by VOSO (4). Thus ROFA-stimulated production of ROS from mitochondria was independent of apoptosis of AM, which was mediated by activation of caspase-3-like proteases and NO. |
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| 17992568 | Ahmadi FA, Grammatopoulos TN, Poczobutt AM, Jones SM, Snell LD, Das M, Zawada WM: selectively sensitizes dopaminergic neurons to rotenone-induced apoptosis. Neurochem Res. 2008 May;33(5):886-901. Epub 2007 Nov 10. Furthermore, mitochondrial superoxide dismutase mimetic, (III) meso-tetrakis (4- blocked activation of caspase-3, and consequent cell death. |
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| 11097871 | Gennari A, Viviani B, Galli CL, Marinovich M, Pieters R, Corsini E: Organotins induce apoptosis by disturbance of [Ca (2+)](i) and mitochondrial activity, causing oxidative stress and activation of caspases in rat thymocytes. Toxicol Appl Pharmacol. 2000 Dec 1;169(2):185-90. Furthermore, we demonstrated that rotenone prevents apoptosis induced by 3 microM DBTC or TBTC and, in addition, that both BAPTA and Z-DEVD FMK (mainly a caspase-3 inhibitor) decreased apoptosis by DBTC (already shown for TBTC). |
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| 18242171 | Chen S, Zhang X, Yang D, Du Y, Li L, Li X, Ming M, Le W: D2/D3 receptor agonist ropinirole protects dopaminergic cell line against rotenone-induced apoptosis through inhibition of caspase- and JNK-dependent pathways. FEBS Lett. 2008 Mar 5;582(5):603-10. Epub 2008 Jan 31. Furthermore, we demonstrated that ropinirole can reduce the rotenone-induced cleavages of caspase 9, caspase 3 and PARP and elevate the expression of anti-apoptotic proteins of p-Akt and bcl-2. |
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| 16219024 | Hoglinger GU, Lannuzel A, Khondiker ME, Michel PP, Duyckaerts C, Feger J, Champy P, Prigent A, Medja F, Lombes A, Oertel WH, Ruberg M, Hirsch EC: The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy. J Neurochem. 2005 Nov;95(4):930-9. Epub 2005 Aug 10. Some cells with abnormal tau immunoreactivity contained activated caspase 3. |
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| 17690326 | Nutku-Bilir E, Hudson SA, Bochner BS: Interleukin-5 priming of human eosinophils alters siglec-8 mediated apoptosis pathways. Am J Respir Cell Mol Biol. 2008 Jan;38(1):121-4. Epub 2007 Aug 9. Previously, we have identified the sequential activation of reactive species (ROS), mitochondria, and caspase-3, -8, and -9, in Siglec-8-mediated eosinophil apoptosis. Finally, both the mitochondrial electron transport inhibitor rotenone, and the ROS inhibitors diphenyleneiodonium and antimycin, completely inhibited Siglec-8-mediated apoptosis, even after IL-5 priming. |
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| 17047462 | Kim SJ, Kim JS, Cho HS, Lee HJ, Kim SY, Kim S, Lee SY, Chun HS: a component of rosemary (Rosmarinus officinalis L.) protects nigral dopaminergic neuronal cells. Neuroreport. 2006 Nov 6;17(16):1729-33. In this study, we investigated the protective effects of on rotenone-induced neurotoxicity in cultured dopaminergic cells. Results showed that cell viability was significantly improved with through downregulation of caspase-3. |
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