Protein Information

Name inducible NO synthase
Synonyms Calcium calmodulin independent nitric oxide synthase iNOS protein; NOS 2; NOS2; NOS; HEP NOS; Hepatocyte NOS; INOS; Inducible NO synthase…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
17196160 Yamamoto F, Ohgari Y, Yamaki N, Kitajima S, Shimokawa O, Matsui H, Taketani S: The role of nitric oxide in delta-aminolevulinic acid (ALA)-induced photosensitivity of cancerous cells. Biochem Biophys Res Commun. 2007 Feb 16;353(3):541-6. Epub 2006 Dec 22.

The levels of mitochondrial ferrochelatase and rotenone-sensitive NADH dehydrogenase in the NOS2-induced cells decreased.
9(0,0,1,4) Details
8700134 Duval DL, Miller DR, Collier J, Billings RE: Characterization of hepatic nitric oxide synthase: identification as the cytokine-inducible form primarily regulated by oxidants. Mol Pharmacol. 1996 Aug;50(2):277-84.

Cytokine treatment increased nuclear factor-kappa B binding, and the addition of antioxidants or rotenone inhibited cytokine activation.
Hepatic NOS activity was cytosolic and had cofactor requirements consistent with inducible nitric oxide synthase (NOS2).
2(0,0,0,2) Details
16120427 Blanco FJ, Lopez-Armada MJ, Maneiro E: Mitochondrial dysfunction in osteoarthritis. . Mitochondrion. 2004 Sep;4(5-6):715-28. Epub 2004 Oct 1.


Inhibition of complex I with rotenone increases the expression and synthesis of Bcl-2 and Cox-2, both effects are similar effects to produced by IL-1 in human chondrocytes.
0(0,0,0,0) Details