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Gutierrez JA, Inman RS, Akompong T, Yu J, Wessling-Resnick M: Metabolic depletion inhibits the uptake of nontransferrin-bound iron by K562 cells. J Cell Physiol. 1998 Dec;177(4):585-92.
Incubation with 1 microM rotenone, 10 microM antimycin, or 0.5 mM 2,4-dinitrophenol effectively reduced ATP levels by approximately 50%. These features possibly reflect properties of the transport mechanism associated with a recently identified K562 cell transport protein, called SFT for "Stimulator of Fe Transport," since exogenous expression of its activity is also affected by ATP depletion. |
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