| Name | CD8 |
|---|---|
| Synonyms | CD8; p32; MAL; CD8A; CD8a antigen; CD8a molecule; LEU2 T lymphocyte antigen; Leu2… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16818739 | Yi JS, Holbrook BC, Michalek RD, Laniewski NG, Grayson JM: Electron transport complex I is required for CD8+ T cell function. . J Immunol. 2006 Jul 15;177(2):852-62. To block mitochondrial function, transgenic CD8+ T cells were incubated with increasing doses of rotenone, an inhibitor of electron transport complex I. |
6(0,0,0,6) | Details |
| 7670095 | Macho A, Castedo M, Marchetti P, Aguilar JJ, Decaudin D, Zamzami N, Girard PM, Uriel J, Kroemer G: Mitochondrial dysfunctions in circulating T lymphocytes from human immunodeficiency virus-1 carriers. Blood. 1995 Oct 1;86(7):2481-7. CD4+ or CD8+ cells from clinically asymptomatic HIV-1 carriers contain a significantly elevated percentage of cells endowed with enhanced HE --> Eth conversion and/or reduced DiOC6 (3) uptake as compared with normal controls. Control experiments involving rotenone, an inhibitor of the respiratory chain complex I, indicate that the reactive species responsible for HE --> Eth conversion is generated during mitochondrial electron transport. |
1(0,0,0,1) | Details |
| 9199966 | Katsikis PD, Garcia-Ojeda ME, Torres-Roca JF, Greenwald DR, Herzenberg LA, Herzenberg LA: HIV type 1 Tat protein enhances activation-but not Fas (CD95)-induced peripheral blood T cell apoptosis in healthy individuals. Int Immunol. 1997 Jun;9(6):835-41. Examining the mechanisms by which Tat induces apoptosis, we found that inhibitors of reactive intermediate (ROI) generation or neutralizers of ROI, such as rotenone, a potent inhibitor of mitochondrial complex I of the respiratory chain, and 3,3,5,5-tetramethylpyrroline N-oxide (TMPO), an electron spin trap, could both enhance the spontaneous apoptosis induced by Tat. |
0(0,0,0,0) | Details |