| 17706936 |
Luis PB, Ruiter JP, Aires CC, Soveral G, de Almeida IT, Duran M, Wanders RJ, Silva MF: Valproic acid metabolites inhibit dihydrolipoyl dehydrogenase activity leading to impaired 2-oxoglutarate-driven oxidative phosphorylation. Biochim Biophys Acta. 2007 Sep;1767(9):1126-33. Epub 2007 Jul 10.
No inhibitory effect on OXPHOS was observed when succinate (plus rotenone) was used as substrate.
We tested the hypothesis that dihydrolipoyl dehydrogenase (DLDH) might be a direct target of VPA, especially its acyl-CoA intermediates. |
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