| Name | P2X2 |
|---|---|
| Synonyms | ATP receptor; Purinergic receptor; P2RX2; P2X purinoceptor 2; P2X receptor subunit 2; P2X2; Purinergic receptor P2X ligand gated ion channel 2; Purinergic receptor P2X2… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15331767 | Mason HS, Bourke S, Kemp PJ: Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive species. Mol Pharmacol. 2004 Dec;66(6):1525-35. Epub 2004 Aug 26. Inhibitors of the mitochondrial electron transport chain that reduce (rotenone and myxothiazol) or increase (antimycin A) the production of ROS altered the magnitude of P2X2-mediated currents. |
86(1,1,1,6) | Details |
| 19793987 | Coddou C, Codocedo JF, Li S, Lillo JG, Acuna-Castillo C, Bull P, Stojilkovic SS, Huidobro-Toro JP: Reactive species potentiate the P2X2 receptor activity through intracellular Cys430. J Neurosci. 2009 Sep 30;29(39):12284-91. Because mercury could act as an oxidative stress inducer, we also tested whether peroxide (H (2) O (2)) and mitochondrial stress inducers myxothiazol and rotenone mimicked mercury effects. |
1(0,0,0,1) | Details |