| Name | phosphofructokinase |
|---|---|
| Synonyms | PFK 1; Phosphofructokinase 1; Phosphohexokinase; PFK A; PFK1; PFKM; PFKM protein; Phosphofructo 1 kinase isozyme A… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16972982 | Liu L, Li Y, Li H, Chen J: Significant increase of glycolytic flux in Torulopsis glabrata by inhibition of oxidative phosphorylation. FEMS Yeast Res. 2006 Dec;6(8):1117-29. One was separately adding, at 10 mg L1, specific inhibitors of complex I (rotenone) or of the bc1 complex (antimycin A) to the culture broth of T. glabrata CCTCC M202019, which resulted in significantly decreased intracellular ATP levels (43% and 27.7%) and significantly increased rates of consumption (qs) and production (qp); another approach was breeding a respiratory-deficient mutant RD-16, in which cytochromes aa3 and b in the ETC were deleted after ethidium mutagenesis, to reduce the ETC activity constitutively. With the two strategies, the specific activity of phosphofructokinase (R2=0.9971), the average specific consumption rate (R2=0.9967) and the average specific production rate (R2=0.965) were closely correlated with the intracellular ATP level, all of them being increased at a lower intracellular ATP level. |
1(0,0,0,1) | Details |
| 1531411 | Dagani F, Ferrari R, Tosca P, Canevari L: Effects of antagonists on glycolysis of rat brain synaptosomes. Biochem Pharmacol. 1992 Jan 22;43(2):371-4. The effects of antagonists nimodipine, nicardipine and flunarizine on lactate production and specific activities of some enzymes regulating glycolytic flux have been evaluated in synaptosomes isolated from rat whole brain and submitted to in vitro chemical hypoxia induced by rotenone, an inhibitor of mitochondrial respiration. The following enzymes have been tested; hexokinase (ATP: D-hexose-6-phosphotransferase, EC2.7.1.1), phosphofructokinase (ATP: 1-phosphotransferase, EC 2.7.1.11) and kinase (ATP: 2-O-phosphotransferase, EC 2.7.1.40). |
1(0,0,0,1) | Details |
| 7595576 | Erecinska M, Deas J, Silver IA: The effect of pH on glycolysis and phosphofructokinase activity in cultured cells and synaptosomes. J Neurochem. 1995 Dec;65(6):2765-72. Addition of rotenone markedly enhanced glycolysis at all pHe values studied. |
1(0,0,0,1) | Details |